1,447 research outputs found

    Investment under ambiguity with the best and worst in mind

    Get PDF
    Recent literature on optimal investment has stressed the difference between the impact of risk and the impact of ambiguity - also called Knightian uncertainty - on investors' decisions. In this paper, we show that a decision maker's attitude towards ambiguity is similarly crucial for investment decisions. We capture the investor's individual ambiguity attitude by applying alpha-MEU preferences to a standard investment problem. We show that the presence of ambiguity often leads to an increase in the subjective project value, and entrepreneurs are more eager to invest. Thereby, our investment model helps to explain differences in investment behavior in situations which are objectively identical

    Insights into the pre-initiation events of bacteriophage phi6 RNA-dependent RNA polymerase : towards the assembly of a productive binary complex

    Get PDF
    The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. In order to initiate RNA polymerization, viral RdRPs must be able to interact with the incoming 3 terminus of the template and position it, so that a productive binary complex is formed. Structural studies have revealed that RdRPs of dsRNA viruses that lack helicases have electrostatically charged areas on the polymerase surface, which might facilitate such interactions. In this study, structure-based mutagenesis, enzymatic assays and molecular mapping of bacteriophage 6 RdRP and its RNA were used to elucidate the roles of the negatively charged plough area on the polymerase surface, of the rim of the template tunnel and of the template specificity pocket that is key in the formation of the productive RNA-polymerase binary complex. The positively charged rim of the template tunnel has a significant role in the engagement of highly structured ssRNA molecules, whereas specific interactions further down in the template tunnel promote ssRNA entry to the catalytic site. Hence, we show that by aiding the formation of a stable binary complex with optimized RNA templates, the overall polymerization activity of the 6 RdRP can be greatly enhanced.The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. In order to initiate RNA polymerization, viral RdRPs must be able to interact with the incoming 3 terminus of the template and position it, so that a productive binary complex is formed. Structural studies have revealed that RdRPs of dsRNA viruses that lack helicases have electrostatically charged areas on the polymerase surface, which might facilitate such interactions. In this study, structure-based mutagenesis, enzymatic assays and molecular mapping of bacteriophage 6 RdRP and its RNA were used to elucidate the roles of the negatively charged plough area on the polymerase surface, of the rim of the template tunnel and of the template specificity pocket that is key in the formation of the productive RNA-polymerase binary complex. The positively charged rim of the template tunnel has a significant role in the engagement of highly structured ssRNA molecules, whereas specific interactions further down in the template tunnel promote ssRNA entry to the catalytic site. Hence, we show that by aiding the formation of a stable binary complex with optimized RNA templates, the overall polymerization activity of the 6 RdRP can be greatly enhanced.The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. In order to initiate RNA polymerization, viral RdRPs must be able to interact with the incoming 3 terminus of the template and position it, so that a productive binary complex is formed. Structural studies have revealed that RdRPs of dsRNA viruses that lack helicases have electrostatically charged areas on the polymerase surface, which might facilitate such interactions. In this study, structure-based mutagenesis, enzymatic assays and molecular mapping of bacteriophage 6 RdRP and its RNA were used to elucidate the roles of the negatively charged plough area on the polymerase surface, of the rim of the template tunnel and of the template specificity pocket that is key in the formation of the productive RNA-polymerase binary complex. The positively charged rim of the template tunnel has a significant role in the engagement of highly structured ssRNA molecules, whereas specific interactions further down in the template tunnel promote ssRNA entry to the catalytic site. Hence, we show that by aiding the formation of a stable binary complex with optimized RNA templates, the overall polymerization activity of the 6 RdRP can be greatly enhanced.Peer reviewe

    Transverse Momentum and Rapidity Dependence of HBT Correlations in Au+Au Collisions at sqrt(s_NN) = 62.4 and 200 GeV

    Full text link
    Two-particle correlations of identical charged pion pairs from Au+Au collisions at sqrt(s_NN) = 62.4 and 200 GeV were measured by the PHOBOS experiment at RHIC. Data for the 15% most central events were analyzed with Bertsch-Pratt and Yano-Koonin-Podgoretskii parameterizations using pairs with rapidities of 0.4 < y_{\pi\pi} < 1.3 and transverse momenta 0.1 < k_T < 1.4 GeV/c. The Bertsch-Pratt radii R_o and R_l decrease as a function of pair transverse momentum, while R_s is consistent with a weaker dependence. R_o and R_s are independent of collision energy, while R_l shows a slight increase. The source rapidity y_{ykp} scales roughly with the pair rapidity y_{\pi\pi}, indicating strong dynamical correlations.Comment: 5 pages, 4 figures, 2 tables, submitted to Phys. Rev.

    Landau theory applied to phase transitions in calcium orthotungstate and isostructural compounds

    Full text link
    The pressure-driven tetragonal-to-monoclinic phase transition in CaWO4 and related scheelite-structured orthotungstates is analysed in terms of spontaneous strains. Based upon our previous high-pressure x-ray diffraction results and the Landau theory, it is suggested that the scheelite-to-fergusonite transition is of second order in nature.Comment: 14 pages, 3 figure

    Charged antiparticle to particle ratios near midrapidity in p+p collisions at sqrt(s_NN)=200 GeV

    Full text link
    The ratios of the yields of primary charged antiparticles to particles have been obtained for pions, kaons, and protons near midrapidity for p+p collisions at sqrt(s_NN) = 200 GeV. Ratios of =1.000 +/- 0.012 (stat.) +/- 0.019 (syst.), =0.93 +/- 0.05 (stat.) +/- 0.03 (syst.), and =0.85 +/- 0.04 (stat.) +/- 0.03 (syst.) have been measured. The reported values represent the ratio of the yields averaged over the rapidity range of 0.1<y_{pi}<1.3 and 0<y_{K,p}<0.8, and for transverse momenta of 0.1<p_T^{pi,K}<1.0 GeV/c and 0.3<p_T^{p}<1.0 GeV/c. Within the uncertainties, all three ratios are consistent with the values measured in d+Au collisions at the same energy. The data are compared to results from other collision systems and energies.Comment: 3 pages, 2 figures, 1 table, submitted to Phys. Rev.

    Energy dependence of elliptic flow over a large pseudorapidity range in Au+Au collisions at RHIC

    Full text link
    This paper describes the measurement of the energy dependence of elliptic flow for charged particles in Au+Au collisions using the PHOBOS detector at the Relativistic Heavy Ion Collider (RHIC). Data taken at collision energies of sNN=\sqrt{s_{_{NN}}} = 19.6, 62.4, 130 and 200 GeV are shown over a wide range in pseudorapidity. These results, when plotted as a function of ηâ€Č=âˆŁÎ·âˆŁâˆ’ybeam\eta'=|\eta|-y_{beam}, scale with approximate linearity throughout ηâ€Č\eta', implying no sharp changes in the dynamics of particle production as a function of pseudorapidity or increasing beam energy.Comment: 5 pages, 4 figure

    Forward-Backward Multiplicity Correlations in sqrt(s_NN) = 200 GeV Gold-Gold Collisions

    Full text link
    Forward-backward correlations of charged-particle multiplicities in symmetric bins in pseudorapidity are studied in order to gain insight into the underlying correlation structure of particle production in Au+Au collisions. The PHOBOS detector is used to measure integrated multiplicities in bins centered at eta, defined within |eta|<3, and covering intervals Delta-eta. The variance sigma^2_C of a suitably defined forward-backward asymmetry variable C is calculated as a function of eta, Delta-eta, and centrality. It is found to be sensitive to short range correlations, and the concept of "clustering'' is used to interpret comparisons to phenomenological models.Comment: 5 Pages, 5 Figures, submitted to Physical Review C -- Rapid Communication

    Centrality dependence of charged hadron transverse momentum spectra in d+Au collisions at sqrt(s_NN) = 200 GeV

    Full text link
    We have measured transverse momentum distributions of charged hadrons produced in d+Au collisions at sqrt(s_NN) = 200 GeV. The spectra were obtained for transverse momenta 0.25 < p_T < 6.0 GeV/c, in a pseudorapidity range of 0.2 < eta < 1.4 in the deuteron direction. The evolution of the spectra with collision centrality is presented in comparison to p+pbarcollisions at the same collision energy. With increasing centrality, the yield at high transverse momenta increases more rapidly than the overall particle density, leading to a strong modification of the spectral shape. This change in spectral shape is qualitatively different from observations in Au+Au collisions at the same energy. The results provide important information for discriminating between different models for the suppression of high-p_T hadrons observed in Au+Au collisions.Comment: 5 pages, 4 figures, submitted to PR

    Centrality and pseudorapidity dependence of elliptic flow for charged hadrons in Au+Au collisions at sqrt(sNN) = 200 GeV

    Full text link
    This paper describes the measurement of elliptic flow for charged particles in Au+Au collisions at sqrt(sNN)=200 GeV using the PHOBOS detector at the Relativistic Heavy Ion Collider (RHIC). The measured azimuthal anisotropy is presented over a wide range of pseudorapidity for three broad collision centrality classes for the first time at this energy. Two distinct methods of extracting the flow signal were used in order to reduce systematic uncertainties. The elliptic flow falls sharply with increasing eta at 200 GeV for all the centralities studied, as observed for minimum-bias collisions at sqrt(sNN)=130 GeV.Comment: Final published version: the most substantive change to the paper is the inclusion of a complete description of how the errors from the hit-based and track-based analyses are merged to produce the 90% C.L. errors quoted for the combined results shown in Fig.

    The Landscape of Particle Production: Results from PHOBOS

    Full text link
    Recent results from the PHOBOS experiment at RHIC are presented, both from Au+Au collisions from the 2001 run and p+p and d+Au collisions from 2003. The centrality dependence of the total charged particle multiplicity in p+p and d+Au show features, such as Npart-scaling and limiting fragmentation, similar to p+A collisions at lower energies. Multiparticle physics in Au+Au is found to be local in (pseudo)rapidity, both when observed by HBT correlations and by forward-backward pseudorapidity correlations. The shape of elliptic flow in Au+Au, measured over the full range of pseudorapidity, appears to have a very weak centrality dependence. Identified particle ratios in d+Au reactions show little difference between the shape of proton and anti-proton spectra, while the absolute yields show an approximate m_T scaling.Comment: 8 Pages, 11 Figures, Plenary talk at Quark Matter 2004, Oakland, CA, January 11-18, 200
    • 

    corecore