7 research outputs found
Impact of allogeneic red blood cell transfusion on prognosis in soft tissue sarcoma patients: a single‐centre study
Prognostic relevance of ABO blood group system in non-metastatic renal cell carcinoma: an analysis of two independent european cohorts with long-term follow-up
High-dose intravenously administered iron versus orally administered iron in blood donors with iron deficiency: study protocol for a randomised, controlled trial
Prognostic effect Of allogeneic red blood cell transfusions in soft tissue sarcoma patients: a retrospective study
Einfluss der perioperativen Erythrozytenkonzentrat-Gabe auf die Prognose von Weichteilsarkom-patient*Innen: eine retrospektive Studie
Additional file 1: of High-dose intravenously administered iron versus orally administered iron in blood donors with iron deficiency: study protocol for a randomised, controlled trial
SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*. (DOCX 63 kb
Impact of allogeneic red blood cell transfusion on prognosis in soft tissue sarcoma patients. A single‐centre study
Abstract Background Perioperatively administered (leukocyte reduced) allogeneic red blood cell transfusions (lrRBCTs) may lead to transfusion‐related immunomodulation and reduced overall survival (OS) in cancer patients. Herein, the effect of lrRBCT on local recurrence (LR), distant metastasis (DM), and OS in soft tissue sarcoma (STS) patients was analysed. Methods Retrospective study on 432 STS patients (mean age: 60.0 ± 17.8 years; 46.1% female), surgically treated at a tertiary tumour centre. Uni‐ and multivariate survival models were calculated to analyse impact of perioperative lrRBCTs on LR, DM, OS. Results Perioperatively, 75 patients (17.4%) had received lrRBCTs. Older patients, deep, large, lower limb STS rather required lrRBCTs (all p < 0.05). No significant association between lrRBCT administration and LR‐ (p = 0.582) or DM‐risk (p = 0.084) was observed. LrRBCT was associated with worse OS in univariate analysis (HR: 2.222; p < 0.001), with statistical significance lost upon multivariate analysis (HR: 1.658; p = 0.059; including age, histology, size, grading, amputation, depth). Adding preoperative haemoglobin in subgroup of 220 patients with laboratory parameters revealed significant negative impact of low haemoglobin on OS (p = 0.014), whilst effect of lrRBCT was further diminished (p = 0.167). Conclusion Unfavourable prognostic factors prevail in STS patients requiring lrRBCTs. Low haemoglobin levels rather than lrRBCT seem to reduce OS