How trust and credibility affect technology-based development projects

Information and communication technology for development (ICTD) involves using information and communication technologies (ICTs) to improve the well-being of people in resource-constrained environments. Because ICTD projects involve crafting technical information and the ICTs that convey it, ICTD involves challenges familiar to technical communicators, such as balancing stakeholder interests and building credibility necessary to influence stakeholders. This article presents how trust and credibility affect ICTD projects, describing implications for development contexts and for distributed work environments

Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

Background: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death. Methods: We performed lipidomics using three models of insulitis: human islets and EndoC-βH1 β cells treated with the pro-inflammatory cytokines interlukine-1β and interferon-γ, and islets from pre-diabetic non-obese mice. We also performed mass spectrometry and fluorescence imaging to determine the localization of lipids and enzyme in islets. RNAi, apoptotic assay, and qPCR were performed to determine the role of a specific factor in lipid-mediated cytokine signaling. Results: Across all three models, lipidomic analyses showed a consistent increase of lysophosphatidylcholine species and phosphatidylcholines with polyunsaturated fatty acids and a reduction of triacylglycerol species. Imaging assays showed that phosphatidylcholines with polyunsaturated fatty acids and their hydrolyzing enzyme phospholipase PLA2G6 are enriched in islets. In downstream signaling, omega-3 fatty acids reduce cytokine-induced β-cell death by improving the expression of ADP-ribosylhydrolase ARH3. The mechanism involves omega-3 fatty acid-mediated reduction of the histone methylation polycomb complex PRC2 component Suz12, upregulating the expression of Arh3, which in turn decreases cell apoptosis. Conclusions: Our data provide insights into the change of lipidomics landscape in β cells during insulitis and identify a protective mechanism by omega-3 fatty acids

Child Labor Laws

Models of public policy implementation proliferated during the 1970s and 1980s. We argue that these models should be robust across different time periods and should accurately postdict and explain the outcomes known to have occurred. This article looks at two models of policy implementation, one developed by Mazmanian and Sabatier and another developed by Nakwnura and Smallwood. Robustness and explanatory ability of these models are assessed using a historical case study of the first national child labor law. This demonstrates the advantages of a historical perspective on policy implementation. Looking at policy across time raises questions about current models of implementation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68057/2/10.1177_009539979502700102.pd