Adipokines and obesity are associated with colorectal polyps in adult males: a cross-sectional study.

Obesity increases the risk of colon cancer. It is also known that most colorectal cancers develop from adenomatous polyps. However, the effects of obesity and adipokines on colonic polyp formation are unknown.To determine if BMI, waist circumference or adipokines are associated with colon polyps in males, 126 asymptomatic men (48-65 yr) were recruited at time of colonoscopy, and anthropometric measures as well as blood were collected. Odds ratios were determined using polytomous logistic regression for polyp number (0 or ≥3) and polyp type (no polyp, hyperplastic polyp, tubular adenoma).41% of the men in our study were obese (BMI ≥30). The odds of an obese individual having ≥3 polyps was 6.5 (CI: 1.3-33.0) times greater than those of a lean (BMI<25) individual. Additionally, relative to lean individuals, obese individuals were 7.8 (CI: 2.0-30.8) times more likely to have a tubular adenoma than no polyp. As BMI category increased, participants were 2.9 (CI: 1.5-5.4) times more likely to have a tubular adenoma than no polyps. Serum leptin, IP-10 and TNF-α were significantly associated with tubular adenoma presence. Serum leptin and IP-10 were significantly associated with increased likelihood of ≥3 polyps, and TNF-α showed a trend (p = 0.09).Obese men are more likely to have at least three polyps and adenomas. This cross-sectional study provides evidence that colonoscopy should be recommended for obese, white males

Differential effects of energy balance on experimentally-induced colitis

AIM: To characterize the influence of diet-induced changes in body fat on colitis severity in SMAD3-/- mice

Association of serum adipokine tertiles with having ≥3 polyps.

<p>Note: Model is adjusted for age and ever/never smoked.</p

Association of BMI with the presence or severity of polyps in the proximal^† or distal^†† colon.

<p>Note: Model is adjusted for age and ever/never smoked.</p><p>Proximal (right) colon included: cecum, ascending colon, and transverse colon</p><p>Distal (left) colon included: descending colon, sigmoid colon, and rectum</p

Participant^† Characteristics.

<p>All participants (n = 126) were male, >96% Caucasian</p><p>Reported as mean (range)</p

Association of serum adipokine tertiles with the presence of a hyperplastic polyp.

<p>Note: Model is adjusted for age and ever/never smoked.</p

Pearson correlation coefficients.

<p>Note: The top number is the Pearson correlation coefficient. The P values are shown under the correlation coefficient.</p

Association of serum adipokine tertiles with the presence of a tubular adenoma.

<p>Note: Model is adjusted for age and ever/never smoked.</p