Supporting Emergent Bilingual Professional Development through Supervisor Feedback

This study examines the effects of professional development on the content and frequency of university supervisor (n=6) written feedback related to supporting emergent bilinguals in order to improve the quality of observational evaluations provided to elementary and secondary pre-service teachers. Findings reveal supervisors’ post-intervention feedback more frequently addressed the needs of language learners and provided a greater breadth of issues related to emergent bilinguals. Interview data reveal key factors explain how the professional development addressed gaps in knowledge and affected confidence levels of university supervisors. Implications highlight the importance of supporting supervisors with targeted professional development opportunities around supporting emergent bilinguals to allow for critical reflection of feedback provided to pre-service teachers

Sources of light-absorbing aerosol in arctic snow and their seasonal variation

Two data sets consisting of measurements of light absorbing aerosols (LAA) in arctic snow together with suites of other corresponding chemical constituents are presented; the first from Siberia, Greenland and near the North Pole obtained in 2008, and the second from the Canadian arctic obtained in 2009. A preliminary differentiation of the LAA into black carbon (BC) and non-BC LAA is done. Source attribution of the light absorbing aerosols was done using a positive matrix factorization (PMF) model. Four sources were found for each data set (crop and grass burning, boreal biomass burning, pollution and marine). For both data sets, the crops and grass biomass burning was the main source of both LAA species, suggesting the non-BC LAA was brown carbon. Depth profiles at most of the sites allowed assessment of the seasonal variation in the source strengths. The biomass burning sources dominated in the spring but pollution played a more significant (though rarely dominant) role in the fall, winter and, for Greenland, summer. The PMF analysis is consistent with trajectory analysis and satellite fire maps

Improvement Science in Teacher Preparation at California State University: How teacher preparation partnerships are building capacity to learn to improve

One of the most pressing educational problems in the United States is improving the quality of teacher preparation (Goldhaber, Liddle, & Theobald, 2013; National Academy of Sciences, National Academy of Engineering, & Institute of Medicine, 2007). Over the last decade the education sector has begun to learn from other sectors -- especially health care -- about the potential power of improvement science as an approach to improving the quality and reliability of educational systems (Bryk, Gomez, Grunow, & LeMahieu, 2015; Coburn, Penuel, & Geil, 2013; Lewis, 2015). Evidence from an effort to improve how beginning teachers are supported in three large urban districts through development and testing of feedback systems demonstrates the promise of improvement science methods for tackling persistent challenges in teaching (Hannan, Russell, Takahashi, & Park, 2015).This Innovation Highlight describes a network-based effort -- the New Generation of Educators Initiative (NGEI), funded by the S.D. Bechtel, Jr. Foundation -- that applies the principles and methods of improvement science (Langley, Moen, Nolan, Nolan, Norman, & Provost, 2009) to the challenge of improving how new teachers are prepared in the California State University System. The initiative emphasizes data-driven, continuous improvement by funding teacher preparation programs to routinely collect and analyze the data needed to monitor teacher candidates' progress toward competency in prioritized skills and to use the results of that analysis to (a) inform clinical support and teaching during the school year and (b) identify meaningful programmatic changes.The NGEI-funded teacher preparation programs also receive support from WestEd and SRI, which have developed a multipronged technical assistance strategy that is informed by improvement science. The technical assistance includes in-person trainings, cross-site webinars, monthly coaching calls with each site, annual convenings, and occasional site visits.The first section of this Innovation Highlight explains the theory of improvement science and how approaches that are informed by improvement science differ from other improvement efforts. The second section describes how NGEI has put this theory into practice through improvement science technical assistance for the NGEI grantees. Examples from the NGEI grantees are included throughout to illustrate how improvement science principles have been applied in the teacher preparation context

New Generation of Educators Initiative: Transforming teacher preparation.

The focus of the New Generation of Educators Initiative (NGEI) was to answer the question "What would it take to transform teacher education?" From 2016 to 2019, with support from the S. D. Bechtel, Jr. Foundation, teacher education programs at 10 California State University (CSU) campuses partnered with local school districts to design and demonstrate innovative practices that could transform teacher preparation. This report documents the learnings from multiple participants in this transformative work, including Foundation program staff and representatives from partnerships between universities and school districts

Population Ecology of the Pale Kangaroo Mouse (Microdipodops pallidus) and Community Diversity at Crescent Dunes, in the Lower Smoky Valley of Central Nevada, USA.

Several species of granivorous rodents inhabit the unique semi-stabilized dune habitats of the Lower Smoky Valley of Nevada, including the pale kangaroo mouse (Microdipodops pallidus). The pale kangaroo mouse is a sand-obligate species endemic to the Great Basin Ecosystem, is historically rare and thought to be in decline yet locally common in this study area. It has been suggested as an indicator species for sparse sand dune habitats in the Great Basin yet little is known about the basic ecology, habitat preferences and community dynamics of this specialized and species. I conducted capture-mark-recapture trapping surveys at 18 grids over 3 years with coincident vegetation and soil surveys. My objectives were to establish baseline information on the basic ecology, demographics, and fine-scale habitat preferences of M. pallidus. I used spatially explicit capture-recapture methods to estimate demographic parameters for M. pallidus and generalized mixed-models to identify habitat associations. Additionally, I investigated the nocturnal rodent community structure, and how rodent diversity is influenced by environmental heterogeneity. I calculated 4 diversity indices and used linear regression to investigate the relative effects of biotic and abiotic heterogeneity on rodent diversity. My results show a negative relationship between M. pallidus and gravelly soils, and a negative relationship between dune variation and community diversity. These results establish important baselines to fill gaps in knowledge and help guide conservation efforts for species and habitats in decline

Causes of variability in light absorption by particles in snow at sites in Idaho and Utah.

This file accompanies “NAmer2014SnowBC_Dohertyetal_v1.xlsx”, which contains data on black carbon (BC) and other light-absorbing particles in snow in Utah and Idaho, for samples collected January-March 2014 in Jan/Feb 2013 and 2014 in Utah. Data are available as an Excel file with headers, or as a comma-separated data file, with no headers. There is one entry per layer of snow sampled. All entries (other than column titles in the .xlsx) are numeric. Detailed information on our measurements can be found in a series of publications, as given below. Description of the instrument and method used to make the measurements: Grenfell, T. C., S. J. Doherty, A. D. Clarke, and S. G. Warren, Spectrophotometric determination of absorptive impurities in snow, Appl. Opt., 50(14), pp.2037-2048, 2011. Summary and discussion of dataset “NAmer2014SnowBC_Dohertyetal.xlsx”, including maps of sample locations: Doherty, S. J., D. A. Hegg, P. K. Quinn, J. E. Johnson, J. P. Schwarz, C. Dang and S. G. Warren, Causes of variability in light absorption by particles in snow at sites in Idaho and Utah, J. Geophys. Res. Atmos., 121, doi:10.1002/2015JD024375, 2016. Note that the measurement and analysis techniques used to produce these data were also used in a broad Arctic survey (2006-2010) of BC and other light-absorbing particles snow, as reported here: Doherty, S. J., S. G. Warren, T. C. Grenfell, A. D. Clarke, and R. E. Brandt: Light-absorbing impurities in Arctic snow, Atmos. Chem. Phys., 10, 11647-11680, doi:10.5194/acp-10-11647-2010, 2010. http://www.atmos-chem-phys.net/10/11647/2010/acp-10-11647-2010.htmlThe data presented are from samples of snow gathered approx. every few days at three sites in central Idaho from 27 January to 24 March 2014. In most cases samples were gathered at intervals throughout the snowpack depth. In a few cases we only sampled newly-fallen surface snow. Samples were also collected from a site to the southeast of Vernal, Utah, mostly of surface snow only, 28 January – 21 February 2013 and 17 January – 17 February, 2014.U.S. Environmental Protection Agency, Grant Number RD-8250380

Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE

PURPOSE Human epidermal growth factor receptor 2 (HER2) targeting plus endocrine therapy (ET) improved clinical benefit in HER2-positive, hormone receptor (HR)-positive metastatic breast cancer (MBC) versus ET alone. Dual HER2 blockade enhances clinical benefit versus single HER2 blockade. The ALTERNATIVE study evaluated the efficacy and safety of dual HER2 blockade plus aromatase inhibitor (AI) in postmenopausal women with HER2-positive/HR-positive MBC who received prior ET and prior neo(adjuvant)/first-line trastuzumab (TRAS) plus chemotherapy. This updated article reflects minor numerical corrections in some secondary efficacy analyses that resulted from programming errors and that do not change the major conclusions of the study. METHODS Patients were randomly assigned (1:1:1) to receive lapatinib (LAP) plus TRAS plus AI, TRAS plus AI, or LAP plus AI. Patients for whom chemotherapy was intended were excluded. The primary end point was progression-free survival (PFS; investigator assessed) with LAP plus TRAS plus AI versus TRAS plus AI. Secondary end points were PFS (comparison of other arms), overall survival (OS), overall response rate (ORR), clinical benefit rate (CBR), and safety. RESULTS Three hundred fifty-five patients were included in this analysis: LAP plus TRAS plus AI (n = 120), TRAS plus AI (n = 117), and LAP plus AI (n = 118). Baseline characteristics were balanced. The study met its primary end point; superior PFS was observed with LAP plus TRAS plus AI versus TRAS plus AI (median PFS, 11 v 5.6 months; hazard ratio, 0.62 [95% CI, 0.45 to 0.88]; P = .0063). A consistent PFS benefit was observed in predefined subgroups. ORR, CBR, and OS also favored LAP plus TRAS plus AI. The median PFS with LAP plus AI versus TRAS plus AI was 8.3 versus 5.6 months (hazard ratio, 0.85 [95% CI, 0.62 to 1.17]; P = .3159). Common adverse events (AEs; >= 15%) with LAP plus TRAS plus AI, TRAS plus AI, and LAP plus AI were diarrhea (69%, 9%, and 51%, respectively), rash (36%, 2%, and 28%, respectively), nausea (22%, 9%, and 22%, respectively), and paronychia (30%, 0%, and 15%, respectively), mostly grade 1 or 2. Serious AEs were reported similarly across the 3 groups, and AEs leading to discontinuation were lower with LAP plus TRAS plus AI. CONCLUSION Dual HER2 blockade with LAP plus TRAS plus AI showed superior PFS benefit versus TRAS plus AI in patients with HER2-positive/HR-positive MBC. This combination offers an effective and safe chemotherapy-sparing alternative treatment regimen for this patient population

Cryptic Chlorination by a Non-haem Iron Enzyme During Cyclopropyl Amino Acid Biosynthesis

Enzymatic incorporation of chlorine, bromine or iodine atoms occurs during the biosynthesis of more than 4,000 natural products1. Halogenation can have significant consequences for the bioactivity of these products so there is great interest in understanding the biological catalysts that perform these reactions. Enzymes that halogenate unactivated aliphatic groups have not previously been characterized. Here we report the activity of five proteins—CmaA, CmaB, CmaC, CmaD and CmaE—in the construction of coronamic acid (CMA; 1-amino-1-carboxy-2-ethylcyclopropane), a constituent of the phytotoxin coronatine synthesized by the phytopathogenic bacterium Pseudomonas syringae2. CMA derives from l-allo-isoleucine, which is covalently attached to CmaD through the actions of CmaA, a non-ribosomal peptide synthetase module, and CmaE, an unusual acyltransferase. We show that CmaB, a member of the non-haem Fe2+, α-ketoglutarate-dependent enzyme superfamily, is the first of its class to show halogenase activity, chlorinating the γ-position of l-allo-isoleucine. Another previously undescribed enzyme, CmaC, catalyses the formation of the cyclopropyl ring from the γ-Cl-l-allo-isoleucine product of the CmaB reaction. Together, CmaB and CmaC execute γ-halogenation followed by intramolecular γ-elimination, in which biological chlorination is a cryptic strategy for cyclopropyl ring formation