Sub-group analyses.

<p>Sub-group analyses.</p

Characteristics of included studies.

a<p>Data from study area, or Joint United Nations Programme on HIV/AIDS national data (adult prevalence) if shown in italics.</p>b<p>Eligible if <13 y and mother HIV-positive, mother HIV status unknown, or mother dead.</p>c<p>35,815/137,268 encountered in the area.</p>d<p>Stated only as following national guidelines for testing.</p>e<p>Excluded non-English and non-Lugandan speakers.</p>f<p>Eligible if mother deceased or HIV-positive.</p>g<p>Study done in period before antiretrovirals were available.</p><p>ELISA, enzyme-linked immunosorbent assay; FP, finger prick; RDT, rapid diagnostic test; VCT, voluntary counselling and testing.</p

Flow diagram of study selection process.

<p>Flow diagram of study selection process.</p

Proportion achieving knowledge of HIV status overall.

<p>Proportion achieving knowledge of HIV status overall.</p

Proportion accepting HBT.

<p>Proportion accepting HBT.</p

Key characteristics of included studies.

<p>Key characteristics of included studies.</p

Assessment of study rigour.

a<p>Where no information is available “not specified” is indicated for these variables, as we considered it possible that these activities were done but not reported in the paper.</p>b<p>Some studies offered testing but results were not promised, e.g., results available only if client sought the result separately; some studies were entirely blinded, e.g., where testing was done for anonymous population HIV prevalence estimation.</p

The cascade of care following community-based detection of HIV in sub-Saharan Africa – A systematic review with 90-90-90 targets in sight - Fig 2

<p><b>a-d: Forest plots showing</b>: </p><p></p><p></p><p><b>Proportions linked-to-care (LTC) by HTS approach (a)</b></p><p></p><p></p><p><b>Proportions LTC by PLWH sub-groups (b)</b></p><p></p><p></p><p><b>Proportions LTC by when CD4-count result was available (c)</b></p><p></p><p></p><p><b>Proportions initiating ART (among those eligible) by HTS approach (d)</b></p><p></p><p></p><p></p> <p><b>Proportions linked-to-care (LTC) by HTS approach (a)</b></p> <p><b>Proportions LTC by PLWH sub-groups (b)</b></p> <p><b>Proportions LTC by when CD4-count result was available (c)</b></p> <p><b>Proportions initiating ART (among those eligible) by HTS approach (d)</b></p

Markers of study quality.

<p>Markers of study quality.</p

<i>In silico</i> model of HIV infection.

<p>(A): The <i>in silico</i> experiments are performed in a 3-dimensional ellipsoidal lattice. The lattice represents a lymph node with a volume of 4 microliters. Each lattice point represents a microscopic volume in which stochastic interactions occur between the modeled entities. Some of the entities in the model are shown in the sketch: CD4+ T-lymphocytes, B-lymphocytes, antibodies (Ab), macrophages (MA), dendritic cells (DC) and interferon γ.(B): The interactions between the main cellular compartments in the adaptive immune response. This network describes the adaptive immune response to HIV, that in our model is simulated by a three dimensional agent-based model of a lymph node. The virus can be in two forms: free virus (infectious virions) and viral genome copies contained in both silently and actively infected cells (provirus). The complexity of this network does not lie in its topology but rather is hidden in the complex spatio-temporal interactions (arrows) between the nodes.</p