Epidemiological trends in the presentation of diabetic ketoacidosis in children newly diagnosed with type 1 diabetes from 2011 to 2017 in Kuwait

BackgroundMonitoring the trends in the presentation of T1D over decades cannot be underestimated as it provides a rich source of information on diabetes-related complications like DKA. DKA represents a medical emergency, with potentially fatal outcome, and thus the prevention of DKA is a priority in diabetes care. The aim of this study is to report on trends in the presentation of DKA in children newly diagnosed with T1D in Kuwait.Material and methodsThis study is based on a retrospective review of children newly diagnosed with T1D aged 14 years or less at three Governmental Hospitals representing three health sectors out of the total six health sectors in the country during the period 2011-2017.ResultsA total of 799 children (376 males and 423 females) were newly diagnosed with T1D. 287 children presented with DKA (35.9%) with only 73 children (9.1%) classified as severe. During the years 2011 to 2017, we note that the percentage of children older than 6 years of age presenting with severe DKA has decreased significantly (p=0.022). Unfortunately, this has not been replicated in children younger than 6 years.ConclusionThis study highlights the importance of continued monitoring of clinical characteristics of children at diagnosis of T1D specifically presenting with DKA to enable diabetes care professionals to appreciate the multifaceted aspects of T1D, in particular the importance of raising awareness of the early signs of the onset of T1D with special attention to DKA and its severe consequences

Experimental evaluation for potential drop in refrigerants under high-ambient conditions

Compliance with the Kyoto Protocol and United Nations Sustainable Development Goals requires nations to lower greenhouse gas emissions. Air conditioners, as contributors to direct and indirect emissions of greenhouse gases, can play a major role in limiting global warming to 1.5 °C above pre-industrial levels. Nations classified as Article Five parties, including 147 nations, are required to completely phase out Hydrochlorofluorocarbons including R-22 in 2040. Some of these nations reside in extremely hot climates, and new refrigerants perform poorly under hot weather conditions. While the time is ticking to the phaseout, transitional solutions can be used to move away from R-22 to facilitate the phase-down, especially for units that are still in service.In this paper, a comparative experimental assessment of R453A and R458A as drop-in replacements for R22 is presented. This study aims to evaluate the performance of the two refrigerants to assess their suitability for countries residing in hot climates during the transitional phase-out and phase-down of refrigerants. R22 is used as the baseline refrigerant because it is widely used in developing nations and performs well under high ambient temperatures, reaching as high as 50 °C. Six ambient temperatures (35 °C, 40 °C, 46 °C, 48 °C, 50 °C, and 52 °C) were tested to evaluate the performance of a concealed ducted split air-conditioning unit. The unit rated cooling capacity is 10.39 kW at 48 °C. The measured cooling capacity in comparison to that of R22 was between 87 % and 96 % and 88 % to 96 % for R453A and R458A, respectively, over the tested range of temperatures. The coefficient of performance compared to the baseline showed degradation of 6 %–17 % and 3–10 % for R435A and R458A, respectively. The compression ratio increased by 9 % to 15 % on average for both tested alternative refrigerants over the tested temperature range. It is concluded that R458A performs well as a drop-in alternative refrigerant to R22 and surpasses that of R453A, as it showed slightly less deviation in coefficient of performance

Krukenburg tumour: Role of 18F-FDG PET/CT in identifying the primary site

Krukenberg tumours are a rare form of metastatic tumours of the ovary. They primary site is usually the gastro-intestinal system with the most common being gastric cancer. We present the case of a 35-year-old female coming in with a large pelvi-abdominal mass for investigation. This pelvic mass showed mild to moderate metabolic activity. 18F-FDG PET-CT was able to identify the primary gastric carcinoma. Subsequent histopathology confirmed this to be gastric adenocarcinoma with metastases to the ovary. Keywords: 18F-FDG PET-CT, metastatic gastric carcinoma, Krukenburg tumour

Advancing urban mobility in the State of Qatar—Establishing a framework for autonomous vehicles in Doha

The Government of Qatar is investing considerable resources in the development of integrated transport infrastructure as a solution to traffic congestion and environmental degradation. Autonomous vehicles are expected to be one of the methodologies for enhancing the quality of the built environment and fostering a more sustainable and environmentally conscious urban milieu. While autonomous cars have the potential to address urban difficulties and be utilized for personal, group, and public transit purposes, their implementation in the specific context of Doha has not been thoroughly analyzed. This research explores the potential impacts that autonomous vehicles are expected to have on travel demands, parking needs, and urban planning. It discusses the benefits and challenges associated with autonomous vehicles and predicts their likely implementation and development based on the different precedents. In addition, it explores how it will affect planning decisions such as drop-off and pick-up areas, parking and public transit. The research utilizes a qualitative approach through literature content analysis, field observations, and mobility analysis. Several case studies are analyzed to explore how autonomous vehicles can operate within a limited zone. The study uncovers the issue of ownership and mode of operation as essential factors that can affect the impact of autonomous vehicles (AVs). In addition, implementing AVs may create complex environmental concerns when greener and more sustainable transportation models are not integrated. It is recommended that Doha adopt integrated planning and implementation of AV technologies to ensure that AVs align harmoniously with the environmental stewardship requirement. The research study also presents urban design frameworks for how existing urban spaces can accommodate autonomous vehicles.This research study was developed as part of two research project schemes awarded and funded by Qatar University: [QUST-2-CENG-2023-1643] Student Grant 2023 Cycle #2, Aug 2023-Dec 2023, ‘Impact of Globalization on Transforming the City: Urban Megaprojects

Impact of Organizational Culture on Academics’ Readiness and Behavioral Intention to Implement eLearning Changes in Kuwaiti Universities during COVID-19

A comprehensive review of the literature indicates that there is a lack of research on the influence of all the organizational culture (OC) types on academics’ readiness and behavioral intention to implement eLearning changes in higher education institutions (HEIs). To address this gap, this study empirically investigates the impact of OC on academics’ readiness and behavioral intention to implement eLearning changes within HEIs in Kuwait during the COVID-19 pandemic. A 218 self-administered survey was distributed to public and private HEIs. The analysis of collected data reveal that the most prominent OCs are hierarchy and market types which support readiness for change. The contribution of this study lies in further understanding the impact of OC on academics’ readiness for eLearning changes and behavioral intention to support eLearning implementation. The findings further offer an original contribution by confirming the mediating role of academics’ readiness for eLearning changes in the relationship between OC and behavioral intention. This paper adds to the change management literature by collecting data during the COVID-19 pandemic within the interesting context of HEIs in the Gulf Cooperation Council (GCC), which is currently scarce. The implications of this study contribute to the sustainability of Kuwaiti HEIs

The Unique Transcriptional Activation Domain of Nuclear Factor-I-X3 Is Critical to Specifically Induce Marker Gene Expression in Astrocytes*

Transcription factors of the nuclear factor 1 (NFI) family regulate normal brain development in vertebrates. However, multiple splice variants of four NFI isoforms exist, and their biological functions have yet to be elucidated. Here, we cloned and analyzed human NFI-X3, a novel splice variant of the nfix gene, which contains a unique transcriptional activation (TA) domain completely conserved in primates. In contrast to previously cloned NFI-X1, overexpression of NFI-X3 potently activates NFI reporters, including glial fibrillary acidic protein (GFAP) reporter, in astrocytes and glioma cells. The GAL4 fusion protein containing the TA domain of NFI-X3 strongly activates the GAL4 reporter, whereas the TA domain of NFI-X1 is ineffective. The expression of NFI-X3 is dramatically up-regulated during the differentiation of neural progenitors to astrocytes and precedes the expression of astrocyte markers, such as GFAP and SPARCL1 (Secreted Protein, Acidic and Rich in Cysteines-like 1). Overexpression of NFI-X3 dramatically up-regulates GFAP and SPARCL1 expression in glioma cells, whereas the knockdown of NFI-X3 diminishes the expression of both GFAP and SPARCL1 in astrocytes. Although activation of astrocyte-specific genes involves DNA demethylation and subsequent increase of histone acetylation, NFI-X3 activates GFAP expression, in part, by inducing alterations in the nucleosome architecture that lead to the increased recruitment of RNA polymerase II