Det é skrill : En studie om högstadieelevers musiklyssning

In this text we wanted to research which kind of music youths listen to, why they listen to music and how they listen to music. We were interested to find out how music effects them positively and negatively. We chose to interview 14 students attending middle- and highschool, both girls and boys, to find out how youths listen to music and how they perceive that music effects them. We concluded in our interview study that youths listen extensively to music. We could clearly see that our informants use music in different ways. Many informants use music to enhance their feelings and many use music to increase their ability to concentrate. It is also evident that the informants use different kinds of music for different situations and contexts, for example when they are sad they want to listen to happy music or when they are doing sports they want to listen to music with a high tempo to endure and to want more. Many informants want their music to be cool, in other words skrill.Validerat; 20130227 (global_studentproject_submitter

Robust Phagocyte Recruitment Controls the Opportunistic Fungal Pathogen Mucor circinelloides in Innate Granulomas In Vivo

Mucormycosis is an emerging fungal infection with extremely high mortality rates in patients with defects in their innate immune response, specifically in functions mediated through phagocytes. However, we currently have a limited understanding of the molecular and cellular interactions between these innate immune effectors and mucormycete spores during the early immune response. Here, the early events of innate immune recruitment in response to infection by Mucor circinelloides spores are modeled by a combined in silico modeling approach and real-time in vivo microscopy. Phagocytes are rapidly recruited to the site of infection in a zebrafish larval model of mucormycosis. This robust early recruitment protects from disease onset in vivo. In silico analysis identified that protection is dependent on the number of phagocytes at the infection site, but not the speed of recruitment. The mathematical model highlights the role of proinflammatory signals for phagocyte recruitment and the importance of inhibition of spore germination for protection from active fungal disease. These in silico data are supported by an in vivo lack of fungal spore killing and lack of reactive oxygen burst, which together result in latent fungal infection. During this latent stage of infection, spores are controlled in innate granulomas in vivo. Disease can be reactivated by immunosuppression. Together, these data represent the first in vivo real-time analysis of innate granuloma formation during the early stages of a fungal infection. The results highlight a potential latent stage during mucormycosis that should urgently be considered for clinical management of patients