Salivary a-synuclein in PD patients and healthy subjects.

<p>Salivary a-syn in patients with Parkinson’s disease (PD) and healthy subjects (HS). Each histogram corresponds to the mean concentration of α-syn_total (panel A), α-syn_olig (panel B) and the α-syn_total/α-syn_olig ratio (panel C) in the saliva of patients with PD (black histogram) and HS (white histogram). Vertical bars denote standard deviation. Asterisk denote significant differences. Scatter-plot (panel D) shows the negative correlation between α-syn_total and α-syn_olig in patients with PD.</p

Correlations of total a-syn with PD patients’ clinical features.

<p>Scatter-plots showing the correlation between α-syn_total and patients’ disease duration (DD) (panel A), Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) (part 1–4) (panel B), Montreal Cognitive Assessment (MOCA) (panel C) and Frontal Assessment Battery (FAB) scores (panel D) in patients with PD.</p