Maternal air pollution exposure and adverse neonatal outcomes. Protocol of a scoping review

Introduction Infant mortality, low birth weight, impaired lung development, later respiratory morbidity and alterations in immune development were associated wirh maternal air pollution exposure. Consecuense of these pregnancy outcomes are increased risk of death in the first month of life, growth retardation, lower IQ and metabolic diseases in adulthood in evidence from China & Australia. Frequency of reported outcomes and the nature, type or extent of evidence in the rest of the world on adverse neonatal outcomes is unclear. Objective To assess the nature, type and extent of evidence related to maternal air pollution exposure and adverse neonatal outcomes Methodology Scoping Literature Review will be conducted. Complete protocol was developed and is avaibable upon request. We search in MEDLINE, EMBASE, Scopus, Virtual Health Library PAHO. We search for all research designs describing maternal air pollution exposure and adverse neonatal outcomes. At least two independent reviewers screen titles and abstracts according to inclusión criteria. Data extraction phase will be carry on a form. No risk of bias assessment will be performed. Search strategies will be reported, including number of references examined, duplicates removed, & full text papers reviewed according to PRISMA-P extention for Scoping. Results will be presented as a "map" of the data in the form of diagrams and tables, including Investigator, year, Country, Date, Objetive, Epidemiological design, Analysis, Population characteristics, Outcomes. We will use Rayyan and Colab interactive environment to support self-learning projects, data analysis. Results We get 12398 articles, full text reviewed 302 and extracted information according forms. Most frequent outcomes include LBW then were grouped by pollutant agent and outcome. Social Impact This Scoping Literature Review will help identifying existing evidence related to maternal air pollution exposure and adverse neonatal outcomes suggesting potential modifiable factors to reduce adverse events after prove effectiveness through research hypotheses