Kinase Gene Expression Profiling of Metastatic Clear Cell Renal Cell Carcinoma Tissue Identifies Potential New Therapeutic Targets - Fig 1

<p>Clustering of kinase genes showing A) normal tissue on the left (N, red), tumor in the middle (T, blue) and metastatic tumor tissue on the right (M, purple), and B) hierarchical clustering of all normal (N, red), tumor (T, blue), and metastatic (M, purple) tissues. Figure legend: X-axis represents the tissue sample, Y-axis represents the kinases. Yellow: up regulated kinases, Blue: down regulated kinases.</p

Patient and tumor characteristics.

<p>Patient and tumor characteristics.</p

Expression of kinase genes in primary tumors from metastatic vs. non-metastatic patients in the validation dataset^*.

<p>Expression of kinase genes in primary tumors from metastatic vs. non-metastatic patients in the validation dataset^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0160924#t005fn001" target="_blank">*</a>}.</p

Top kinase genes overexpressed >1.7 fold in metastases in > a third of patients in all metastases compared to all primary ccRCC tumors in 35 patients from the discovery dataset.

<p>Top kinase genes overexpressed >1.7 fold in metastases in > a third of patients in all metastases compared to all primary ccRCC tumors in 35 patients from the discovery dataset.</p