Growth in Infants Receiving Modified Fat Breast Milk for the Treatment of Chylothorax following Cardiothoracic Surgery

Background: In infants diagnosed with chylothorax, breast milk provision is often discontinued and a medium chain triglyceride (MCT) formula is prescribed. Alternatively, modified fat breast milk (MFBM) can be used as treatment, however its impact on growth is unclear. Objective: To assess growth in cardiac infants receiving nutrient enriched MFBM for chylothorax treatment. Methods: In this open-label trial, infants were randomized in to one of two interventions: Target Fortification, where MFBM protein concentration was measured prior to fortification (n=3); or Higher Initial Concentration, where MFBM was fortified to a higher initial energy and nutrient level (n=2). For this thesis, analysis of the two MFBM interventions were combined. Growth was compared to infants receiving the standard MCT formula treatment (n=7). Results: No differences were found in the change of weight-for-age, length-for-age, head circumference-for-age and weight-for-length z-scores between the groups. Conclusion: Further MFBM subject recruitment is required to determine how the different nutrient enrichment methods impact growth.M.Sc.2019-03-30 00:00:0

Growth in Infants Receiving Modified Fat Breast Milk for the Treatment of Chylothorax following Cardiothoracic Surgery

Background: In infants diagnosed with chylothorax, breast milk provision is often discontinued and a medium chain triglyceride (MCT) formula is prescribed. Alternatively, modified fat breast milk (MFBM) can be used as treatment, however its impact on growth is unclear. Objective: To assess growth in cardiac infants receiving nutrient enriched MFBM for chylothorax treatment. Methods: In this open-label trial, infants were randomized in to one of two interventions: Target Fortification, where MFBM protein concentration was measured prior to fortification (n=3); or Higher Initial Concentration, where MFBM was fortified to a higher initial energy and nutrient level (n=2). For this thesis, analysis of the two MFBM interventions were combined. Growth was compared to infants receiving the standard MCT formula treatment (n=7). Results: No differences were found in the change of weight-for-age, length-for-age, head circumference-for-age and weight-for-length z-scores between the groups. Conclusion: Further MFBM subject recruitment is required to determine how the different nutrient enrichment methods impact growth.M.Sc.2019-03-30 00:00:0

The Healthy Eating Assessment Tool (HEAT): A Simplified 10-Point Assessment of CHILD-2 Dietary Compliance for Children and Adolescents with Dyslipidemia

Traditional dietary assessment tools used to determine achievement of cholesterol-lowering dietary targets, defined in the Cardiovascular Health Integrated Lifestyle Diet (CHILD-2), are time intensive. We sought to determine the utility of the Healthy Eating Assessment Tool (HEAT), a simplified 10-point dietary assessment tool, in relation to meeting dietary cut points of the CHILD-2, as well as its association with markers of adiposity and lipid variables. We performed a 2-year single-center, prospective cross-sectional study of pediatric patients with dyslipidemia. HEAT score associations with meeting CHILD-2 fat targets were modest. Only patients with the highest HEAT scores (good 43%, excellent 64%) met the CHILD-2 cut point of <25% total fat calories (p = 0.03), with a non-significant trend for limiting the percentage of daily saturated fat to <8% (excellent 64%), and no association with cholesterol intake. There were more consistent associations with markers of adiposity (body mass index z-score r = −0.31, p = <0.01 and waist-to-height ratio r = −0.31, p = <0.01), and there was no independent association with lipid levels. While fat-restricted diets are safe, they are not particularly effective for treatment of dyslipidemia or for weight management alone. The HEAT may be a more useful and simplified way of assessing and tracking broader dietary goals in clinical practice

The Healthy Eating Assessment Tool (HEAT): A Simplified 10-Point Assessment of CHILD-2 Dietary Compliance for Children and Adolescents with Dyslipidemia

Traditional dietary assessment tools used to determine achievement of cholesterol-lowering dietary targets, defined in the Cardiovascular Health Integrated Lifestyle Diet (CHILD-2), are time intensive. We sought to determine the utility of the Healthy Eating Assessment Tool (HEAT), a simplified 10-point dietary assessment tool, in relation to meeting dietary cut points of the CHILD-2, as well as its association with markers of adiposity and lipid variables. We performed a 2-year single-center, prospective cross-sectional study of pediatric patients with dyslipidemia. HEAT score associations with meeting CHILD-2 fat targets were modest. Only patients with the highest HEAT scores (good 43%, excellent 64%) met the CHILD-2 cut point of &lt;25% total fat calories (p = 0.03), with a non-significant trend for limiting the percentage of daily saturated fat to &lt;8% (excellent 64%), and no association with cholesterol intake. There were more consistent associations with markers of adiposity (body mass index z-score r = −0.31, p = &lt;0.01 and waist-to-height ratio r = −0.31, p = &lt;0.01), and there was no independent association with lipid levels. While fat-restricted diets are safe, they are not particularly effective for treatment of dyslipidemia or for weight management alone. The HEAT may be a more useful and simplified way of assessing and tracking broader dietary goals in clinical practice.</jats:p

Riqualificazione e valorizzazione: una premessa metodologica

Il testo rappresenta la premessa metodologica alle proposte di riallestimento di alcune sezione dei Musei Civici agli Eremitani a Padova, segnalando le linee guida alla base delle proposte e alcune considerazioni in merito agli aggiornamenti dei criteri espositivi, alla comunicazione in remoto e alla comunicazione

Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of Their Optical and Electrochemical Performance

We report that dihalogeno-substituted benzodithiophenes (BDTs) undergo a smooth ligand-free Suzuki-Miyaura crosscoupling reaction, under air and moderate heating (60 °C), with aryl-, alkenyl- and alkynyltrifluoroborate salts in a biodegradable choline chloride-based eutectic mixture, thereby granting access to valuable p-conjugated BDT compounds (up to 79% yield), which are gaining great interest in the field of material sciences. The optical and electrochemical properties of these systems have been thoroughly investigated by means of absorption and cyclic voltammetry measurements. The first electrooligomerisation study of a representative BDT derivative has also been undertaken