Precise Computation of Energy Levels and Radiative Lifetimes in the s, p, d, and f Sequence of Hydrogen Isotope, with Natural Line Widths

Energy levels and Radiative lifetimes in Deuterium for the following: ns 2S1/2(n≥2), np2Po(1/2,3/2)(n≥2), nd 2D(3/2,5/2)(n≥3), and nf 2Fo(5/2,7/2)(n≥4) sequence have been  evaluated with uncertainties in energies caused due to uncertainty principal. Theoretical calculations performed utilizing the Weakest Bound Electron Potential Model Theory (WBEPMT). Both sets of data show quite an excellent agreement with the experimental data listed at NIST.  This theoretical computation is also a continuation of the work by Raza. S. et al. in Neutral Hydrogen. The high ‘n’ (principal quantum number) values for both sets  of data are presented very first time by utilizing WBEPMT. Keywords: Energy levels, Radiative lifetimes, Quantum defects, Weakest bound electron, Natural line width. DOI: 10.7176/JNSR/9-10-07 Publication date:May 31st 201

Bleeding disorders in the tribe: result of consanguineous in breeding

<p>Abstract</p> <p>Objective</p> <p>To determine the frequency and clinical features of bleeding disorders in the tribe as a result of consanguineous marriages.</p> <p>Design</p> <p>Cross Sectional Study</p> <p>Introduction</p> <p>Countries in which consanguinity is a normal practice, these rare autosomal recessive disorders run in close families and tribes. Here we describe a family, living in village Ali Murad Chandio, District Badin, labeled as haemophilia.</p> <p>Patients & Methods</p> <p>Our team visited the village & developed the pedigree of the whole extended family, up to seven generations. Performa was filled by incorporating patients, family history of bleeding, signs & symptoms, and bleeding from any site. From them 144 individuals were screened with CBC, bleeding time, platelet aggregation studies & RiCoF. While for PT, APTT, VWF assay and Factor VIII assay, samples were kept frozen at -70 degrees C until tested.</p> <p>Results</p> <p>The family tree of the seven generations comprises of 533 individuals, 63 subjects died over a period of 20 years and 470 were alive. Out of all those 144 subjects were selected on the basis of the bleeding history. Among them 98(68.1%) were diagnosed to have a bleeding disorder; 44.9% patients were male and 55.1% patients were female. Median age of all the patients was 20.81, range (4 months- 80 yrs). The results of bleeding have shown that majority had gum bleeding, epistaxis and menorrhagia. Most common bleeding disorder was Von Willebrand disease and Platelet functional disorders.</p> <p>Conclusion</p> <p>Consanguineous marriages keep all the beneficial and adversely affecting recessive genes within the family; in homozygous states. These genes express themselves and result in life threatening diseases. Awareness, education & genetic counseling will be needed to prevent the spread of such common occurrence of these bleeding disorders in the community.</p

Comparison of tooth shade matching using visual and digital camera methods

Accurate recording of the shade of the tooth, its communication to the dental laboratory and its reproduction plays a fundamental role in the restorative and prosthetic procedures. Visual shade selection with a reference shade guide is the most common method for shade matching employed in routine clinical practice but it is associated with a high degree of subjectivity. Recently digital devices like colorimeters and spectrometers have been developed to objectively measure the colour. These devices can read the colour data in terms of luminance (L), chroma (C), and hue (h). Researchers have also used high end digital cameras in combination with graphical softwares to measure the tooth colour. A photograph with a digital camera can replicate the true colours and presents this information in terms of numerical data. The aim of this study is to compare the tooth shade matching using simple visual method and digital camera assisted method. In vitro experimental study conducted at the prosthetic laboratory of Aga Khan University Hospital, Pakistan All shade tabs from a vita classic shade guide were photographed using a compact digital camera to acquire three images of each tab at a pre-set object-camera distance generating 144 reference images. Same was done with six masked tabs to acquire a set of 18 test images. Colour values were obtained for an area over body of each image and the closest match between test and reference tabs was determined for digital method. For visual method, participants were asked to match the tooth shade. The outcome was correct match versus incorrect match. Data was analyzed using SPSS 19.0. Chi square test was applied to compare the visual and digital methods and to compare colour matching skills of the dentists and their assistants. P value of \u3c0.05 was taken as significant. With the visual and digital method, correct shade was selected in 39.4% and 66% cases respectively. The digital method yielded better shade matching that was statistically significant Digital colour matching was found to be superior to the visual method. Significantly better shade selection can be done by using compact digital cameras as compared to the visual method alone. Males and dental assistants exhibited better colour matching skills than females and the dentists

Inventory management optimization with data analytics for a trading company

Distributors, manufacturers, and suppliers face the daunting challenge of inventory control. Each supply management problem that arises has ramifications. To satisfy supply and demand, inventory optimization will ensure that the correct commodity is available in the right amounts, at the right price, and in the right places. Furthermore, companies that optimize their inventory can reduce stock levels and, as a result, prevent bearing expenses and obsolescence write-downs. Data analytics helps suppliers and marketers assess their stocking goals and whether any upstream or downstream problems need to be resolved, which is critical in resource control and optimization processes. This study aims to explore how inventory management optimization, supported by data analytics, would be beneficial for a trading company operating in Oman. Currently, trading companies can only solve inventory management problems by either hiring expensive offshore software or using open-source software with little to no knowledge on how to adapt that software to suit specific needs. An online inventory management system is developed using the Java language and MySQL as the database server. Optimization is performed using the Orange data mining tool. The methodology chosen for application development is the Dynamic Systems Development Method. An interview has been conducted with a trading company employee for data collection purposes and the testing was done to ensure optimal performance. Data analytics was performed on the data collected from the online system and data mining was applied by applying feature reduction methods to optimize the results. The study showed a promising result to provide insights on the latest business trends and access the inventory effectively and efficiently

Lenalidomide induced secondary Acute Lymphoblastic Leukemia in a Multiple Myeloma patient: A case-report

Lenalidomide mechanism of action has been shown to modulate the different components of the immune system. A 68-year-old lady presented to us with severe backache and was then diagnosed with MM. Lenalidomide started as per protocol along with dexamethasone. Later, she presented with complaints of generalized weakness and her workup showed significant blast cells with Pan-B-cell markers consistent with secondary B-ALL. The reported incidence of secondary Acute Lymphocytic Leukemia is 2.3%. The development of more aggressive neoplasm in a patient with prior malignancy dictates a poor outcome and hence such patients should be enrolled in a clinical trial whenever availabl

Bilateral congenital cryptorchidism and unilateral Leydig cell tumor in an adult presenting with gynecomastia and primary infertility: A case report

Introduction and importance: The neoplasms of the testis are sporadic tumors among men. Furthermore, the rarest subset of these is neoplasms belonging to the stromal tumors of the sex cord. Leydig cell tumors are the most common form among the testicular stromal tumors. In our case, the underlying risk factor associated with the development of Leydig cell tumors was cryptorchidism. While mostly unilateral, cases of bilateral cryptorchidism may be present and have been rarely reported. Case presentation: We report a 36-year-old gentleman who presented to us with the inability to carry off intercourse without difficulty attaining erection on stimulation for the past two years. He had a history of left undescended testis since birth, for which he underwent left orchidopexy 20 years ago. An ultrasound of the pelvis showed an oval hypoechoic-shaped heterogeneous mass in the right mid-inguinal canal. Relevant blood investigations showed a deranged hormonal profile. He then underwent an uneventful right radical orchiectomy, histopathology of which was consistent with Leydig cell tumor. Clinical discussion: CT with a history of bilateral cryptorchidism has rarely been reported. This case highlights its clinical presentation, management, and further follow-up in such patients. Conclusion: Bilateral congenital cryptorchidism may be associated with Leydig cell tumor years later in life hence long-term follow-up is required for these patients. The clinical presentation of these tumors may vary among individuals. Any change in physical appearance, hormonal assay, and imaging studies should promptly be followed for possible surgical resection and close monitorin

Prognostic factors, oncological treatment and outcomes of uterine sarcoma: 10 years’ clinical experience from a tertiary care center in Pakistan

Abstract Background Uterine sarcoma is an uncommon aggressive malignancy. Optimal management and prognostic factors have yet to be well recognized due to their rarity and various histological subtypes. This study aims to investigate these patients' prognostic factors, treatment modalities, and oncological outcomes. Methods A single-center retrospective cohort study was conducted on all patients diagnosed with uterine sarcoma and treated from January 2010 to December 2019 in a tertiary-care hospital in Pakistan. The data were analyzed using STATA software and stratified on the histological subtype. Survival rates were estimated using the Kaplan–Meier method. Crude and adjusted hazard ratios with 95% CI were estimated using univariate and multivariate analysis. Results Of the 40 patients, 16(40%) had uterine leiomyosarcoma (u-LMS), 10(25%) had high-grade endometrial stromal sarcoma (HGESS), 8(20%) had low-grade endometrial stromal sarcoma (LGESS) and 6(15%) had other histological subtypes. The median age of all patients was 49 (40–55.5). Thirty-seven (92.5%) patients underwent primary surgical resection, and 24 (60%) patients received adjuvant systemic chemotherapy. The survival plots showed the overall population's DFS of 64 months and the OS of 88 months (p-value = 0.001). The median DFS in all patients was 12 months, and the median OS was 14 months (p-value = 0.001). A small but significant DFS benefit was found in patients who received adjuvant systemic chemotherapy, 13.5 versus 11 months (p-value = 0.001). Multivariate Cox-regression analysis revealed that large tumor size and advanced FIGO stage were substantial factors associated with decreased survival. Conclusion Uterine sarcomas are rare malignancies with poor prognosis. Multiple factors, including tumor size, mitotic count, stage of the disease, and myometrial invasion, impact survival outcomes. Adjuvant treatment may decrease the recurrence rate and improve DFS but do not affect OS

Real-Time Diesel Particulate Matter Monitoring in Underground Mines: Evolution and Applications

Diesel exhaust is a major cause of large number of occupational diseases. Acute and continuous exposure to DPM can cause numerous health issues including respiratory disease, lung disease, heart disease, etc. The NIOSH and the IARC consider DPM as ‘probable carcinogenic’ and ‘carcinogenic’, respectively. In large underground M/NM mines, DPM regulatory compliance is challenging. This paper primarily focuses on the evolution and application of real-time DPM monitoring in mining. This study discusses different monitors performance, their applications, and prospects of DPM monitoring in mining. This paper also presents an overview of core issues of using diesel equipment in underground mines and summarises existing DPM regulations in US and other countries

Role of circulating-tumor DNA in the early-stage non-small cell lung carcinoma as a predictive biomarker

Lung cancer is one of the most common solid malignancies. Tissue biopsy is the standard method for accurately diagnosing lung and many other malignancies over decades. However, molecular profiling of tumors leads to establishing a new horizon in the field of precision medicine, which has now entered the mainstream in clinical practice. In this context, a minimally invasive complementary method has been proposed as a liquid biopsy (LB) which is a blood-based test that is gaining popularity as it provides the opportunity to test genotypes in a unique, less invasive manner. Circulating tumor cells (CTC) captivating the Circulating-tumor DNA (Ct-DNA) are often present in the blood of lung cancer patients and are the fundamental concept behind LB. There are multiple clinical uses of Ct-DNA, including its role in prognostic and therapeutic purposes. The treatment of lung cancer has drastically evolved over time. Therefore, this review article mainly focuses on the current literature on circulating tumor DNA and its clinical implications and future goals in non-small cell lung cance