PRODUCTION OF ALLOYED REACTIVE ALUMINUM FROM NATURAL OR INDUSTRIAL RAW MATERIALS

The paper reviewed the production of alumina by the acid method. The dependence of the change in the phase composition on the firing temperature is analyzed. The process of sulfuric acid leaching is considered.В работе исследована возможность легирования порошков оксида алюминия, получаемых кислым способом, добавками оксидов магния и циркония с целью улучшения их физико-химических свойств

Azoloazines as Perspective Antiglycating Agents for Therapy of Diabetes Complications

This work was supported by Russian Federation Ministry of education and science (grant № 4.6351.2017/8.9) and Russian Foundation for Basic Research (grant № 18-03-00787)

Therapy of Schizoaffective Disorder and Paranoid Schizophrenia with Episodic Course

Background. The use of atypical antipsychotics in schizophrenia contributes to the reduction of psychotic, affective, negative and cognitive disorders.Aims. To evaluate the effectiveness of ziprasidone therapy in patients with schizoaffective disorder and paranoid schizophrenia with episodic course.Materials and methods. In accordance with ICD-10 there were 14 (63.6 %) people with schizoaffective disorder (F25), 8 (36.4 %) people with paranoid schizophrenia, episodic course (F20.x1). Treatment with ziprasidone lasted 42 days. The dose of ziprasidone in 6 patients (27.3 %) was 80 mg, in 10 patients (45.5 %) – 120 mg, in 6 patients (27.3 %) – 160 mg. Evaluation of the effectiveness of ziprasidone therapy was carried out using psychometric scales (PANSS, General clinical impression scale to assess the effectiveness of therapy – CGI-S, CGI-I), adverse events were registered with the UKU scale.Results. The number of respondents was 19 (86.3 %) (reduction of the total score on the PANSS scale > 20 % of the pre-treatment level). Ziprasidone was effective in patients with schizoaffective disorder with a significant decrease in total score on PANSS subscales to the 14 th day of therapy (p < 0.05), with paranoid schizophrenia with episodic course – by the 21st day (p < 0.01). According to the CGI-S scale at the end of therapy, “borderline condition” was observed in 10 patients (52.6 %), mild severity – in 3 (15.8 %), normal condition – in 6 (31.6 %). CGI-I scale showed a significant improvement in 10 patients (52.6 %), marked improvement – in 9 patients (47.4 %). Among the mild adverse events that do not require discontinuation of the drug, we noted: weakness – in 3 patients (15.8 %), drowsiness – in 3 (15.8 %), impaired concentration – in 2 (10.5 %), orthostatic dizziness – in 2 (10.5 %), galactorrhea – in 1 (5.3 %).Conclusions. Ziprasidone is an effective antipsychotic drug that has a safe tolerability profile. It can be used in patients with schizoaffective disorders and paranoid schizophrenia with episodic course

Injuries in physical education classes

In foreign and domestic literature, the problems of combating various types of injuries are widely considered, and there are absolutely insufficient issues on the organization of trauma care and prevention of injuries in physical education classes. In physical education classes, most students are at risk of people who are prone to injury, because the class differs from other subjects by high motor activty, the use of various equipment and sports equipmentВ зарубежной и отечественной литературе довольно широко рассматриваются проблемы борьбы с различными видами травматизма и совершенно недостаточно вопросы по организации травматологической помощи и профилактики травматизма на занятиях физической культурой. На занятиях физической культурой большинство студентов входят в группу риска людей, которые подвержены травматизму, потому что занятие отличается от других предметов высокой двигательной активностью, использованием различного инвентаря и спортивного оборудовани

Antioxidants and Cognitive-Behavioral Therapy in Patients with Functional Dyspepsia

Аim: development of an algorithm for the use of antioxidant cognitive-behavioral therapy in adult patients with functional dyspepsia.Material and methods. The study included 112 adult patients with functional dyspepsia receiving the antioxidant drug Cytoflavin containing succinic acid, inosine, nicotinamide and riboflavin, and cognitive behavioral therapy according to the method of Beck and Jacobson in addition to the main therapy (prokinetics, proton pump inhibitors, psychotropic drugs).Results. Of the total group, 74 patients had an optimal response to the inclusion of an antioxidant and psychotherapy in the treatment regimen (increased quality of life and reduced anxiety) and 38 patients had the insignificant response. It has been established that the main predictors of the successful use of an extended treatment regimen are the patient's disadaptation in relation to the disease, a recent stress factor, the duration of functional dyspepsia, the presence of an overlap syndrome (combination with other functional gastrointestinal disorders).Conclusions. Based on the collection of a small amount of anamnestic information (the duration of functional dyspepsia, the presence of an acute stress factor in the anamnesis), the assessment of the presence of an overlap syndrome and disadaptation in relation to the patient to his illness, the value of the discriminant function is calculated. After comparing it with a threshold, the probability of a positive response to a combination of antioxidant and cognitive-behavioral therapy is estimated. The developed prediction algorithm is valid (sensitivity — 91 %, specificity — 73 %, accuracy — 84.8 %) and allows to optimize the definition of treatment tactics for a patient with functional dyspepsia

New antiglycating agents for diabetes therapy

It was shown that azoloazines (1) demonstrated higher antiglycation activity than reference compound, aminoguanidine, and have some potential as dipeptidylpeptidase-4 inhibitors. By given results this class of heterocycles can be considered as candidate for extended studies to develop drugs against complications of T2DM [1-4].The work was supported by the Ministry of Education and Science of Russia (grant №0836-2020-0058)

Organochlorine Pesticides in Consumer Fish and Mollusks of Liaoning Province, China: Distribution and Human Exposure Implications

Fish and mollusk samples were collected from markets located in 12 cities in Liaoning province, China, during August and September 2007, and 22 organochlorine pesticides (OCPs) were detected. DDT, HCH, endosulfan, chlordane, and HCB were the dominating OCPs, with mean concentrations and ranges of, respectively, 15.41 and 0.57 to 177.56 ng/g, 0.84 and below detection limit (BDL) to 22.99 ng/g, 1.31 and BDL to 13.1 ng/g, 1.05 and BDL to 15.68 ng/g, and 0.63 and BDL to 9.21 ng/g in all fish and mollusk samples. The concentrations of other OCPs generally were low and were detectable in a minority of samples, reflecting the low levels of these OCPs in the study region. In general, OCP concentrations were obviously higher in fish than in mollusks, and higher in freshwater fish than in marine fish, which indicated, first, that freshwater fish are more easily influenced than seawater fish and mollusks by OCP residues in agricultural areas and, second, that there are different biota accumulation factors for OCPs between fish and mollusk. To learn the consumption of fish and mollusk, 256 questionnaires were sent to families in 12 cities of Liaoning province. Using the contamination data, average estimated daily intakes of OCPs via fish and mollusk consumption were calculated, which were used for exposure assessment. The public health risks caused by exposure to OCPs in the course of fish and mollusk consumption were compared to noncancer benchmarks and cancer benchmarks

DIAGNOSTIC VALUE OF SPECIFIC IMMUNE COMPLEXES IN DETECTION OF ACTIVE TUBERCULOSIS INFECTION

The diagnostic of tuberculosis infection, including the use of immunological methods, evolved significant changes. The introduction of new diagnostic tests allowed to improve the diagnosis of latent tuberculosis infection (LTI). However, the positive results of immunological tests in both tuberculosis patients and in those with LTI do not allow to divide these conditions, which requires the development and implementation of new diagnostic approaches.Materials and methods. A prospective study with a survey of two groups of patients was conducted: group I (n=50) - patients with verified pulmonary tuberculosis, MBT (+); group II (n =15) – subjects with LTI and control group – healthy subjects (n=14). The examination complex included clinical, radiological, bacteriological, immunological (Mantoux test with 2 TU, T-SPOT.TB, QFT and Diaskintest) methods. Immune complexes were determined in all patients and healthy individuals by the method of dynamic light scattering after the in vitro addition of specific antigens - peptides ESAT-6 and SFP-10.Results. The obtained data demonstrate the low informativeness of the clinical method in the diagnostic of pulmonary tuberculosis. In the presence of characteristic X-ray changes, bacteriological verification of tuberculosis was obtained only in 46% of cases. The use of various immunological tests allows to obtain positive test results in 84-90% of cases simultaneously with the 100% of the positive results in subjects with LTI. Determination of specific immune complexes by the method of dynamic light scattering allows to determine the activity of tuberculosis infection in 100 % of cases and to identify a high-risk group for the development of active tuberculosis in people with latent tuberculosis infection.Conclusions: the obtained data can be applied not only in the diagnosis of active tuberculosis in the absence of diagnosis verification, but also allow to identify a high-risk group for the development of the disease in people with latent tuberculosis infection