1,798 research outputs found
Interplay of 4f-3d Magnetism and Ferroelectricity in DyFeO3
DyFeO3 exhibits a weak ferromagnetism (TNFe ~ 645 K) that disappears below a
spin-reorientation (Morin) transition at TSRFe ~ 50 K. It is also known that
applied magnetic field induces ferroelectricity at the magnetic ordering
temperature of Dy-ions (TNDy ~ 4.5 K). Here, we show that the ferroelectricity
exists in the weak ferromagnetic state (TSRFe < T < TN,C) without applying
magnetic field, indicating the crucial role of weak ferromagnetism in inducing
ferroelectricity. 57Fe M\"ossbauer studies show that hyperfine field (Bhf)
deviates from mean field-like behaviour that is observed in the weak
ferromagnetic state and decreases below the onset of spin-reorientation
transition (80 K), implying that the Bhf above TSR had additional contribution
from Dy-ions due to induced magnetization by the weak ferromagnetic moment of
Fe-sublattice and below TSR, this contribution decreases due to collinear
ordering of Fe-sublattice. These results clearly demonstrate the presence of
magnetic interactions between Dy(4f) and Fe(3d) and their correlation with
ferroelectricity in the weak ferromagnetic state of DyFeO3.Comment: 5 pages, 6 figures, published in EP
Coupling parameters and the form of the potential via Noether symmetry
We explore the conditions for the existence of Noether symmetries in the
dynamics of FRW metric, non minimally coupled with a scalar field, in the most
general situation, and with nonzero spatial curvature. When such symmetries are
present we find general exact solution for the Einstein equations. We also show
that non Noether symmetries can be found.
Finally,we present an extension of the procedure to the Kantowski- Sachs
metric which is particularly interesting in the case of degenerate Lagrangian.Comment: 13 pages, no figure
Heap Reference Analysis Using Access Graphs
Despite significant progress in the theory and practice of program analysis,
analysing properties of heap data has not reached the same level of maturity as
the analysis of static and stack data. The spatial and temporal structure of
stack and static data is well understood while that of heap data seems
arbitrary and is unbounded. We devise bounded representations which summarize
properties of the heap data. This summarization is based on the structure of
the program which manipulates the heap. The resulting summary representations
are certain kinds of graphs called access graphs. The boundedness of these
representations and the monotonicity of the operations to manipulate them make
it possible to compute them through data flow analysis.
An important application which benefits from heap reference analysis is
garbage collection, where currently liveness is conservatively approximated by
reachability from program variables. As a consequence, current garbage
collectors leave a lot of garbage uncollected, a fact which has been confirmed
by several empirical studies. We propose the first ever end-to-end static
analysis to distinguish live objects from reachable objects. We use this
information to make dead objects unreachable by modifying the program. This
application is interesting because it requires discovering data flow
information representing complex semantics. In particular, we discover four
properties of heap data: liveness, aliasing, availability, and anticipability.
Together, they cover all combinations of directions of analysis (i.e. forward
and backward) and confluence of information (i.e. union and intersection). Our
analysis can also be used for plugging memory leaks in C/C++ languages.Comment: Accepted for printing by ACM TOPLAS. This version incorporates
referees' comment
Tuning the Curie temperature of FeCo compounds by tetragonal distortion
Combining density-functional theory calculations with a classical Monte Carlo
method, we show that for B2-type FeCo compounds tetragonal distortion gives
rise to a strong reduction of the Curie temperature . The
monotonically decreases from 1575 K (for ) to 940 K
(for c/a=\sqrtwo). We find that the nearest neighbor Fe-Co exchange
interaction is sufficient to explain the behavior of the
. Combination of high magnetocrystalline anisotropy energy with
a moderate value suggests tetragonal FeCo grown on the Rh
substrate with to be a promising material for heat-assisted magnetic
recording applications.Comment: 4 pages, 2 figure
Viscous instabilities in flowing foams: A Cellular Potts Model approach
The Cellular Potts Model (CPM) succesfully simulates drainage and shear in
foams. Here we use the CPM to investigate instabilities due to the flow of a
single large bubble in a dry, monodisperse two-dimensional flowing foam. As in
experiments in a Hele-Shaw cell, above a threshold velocity the large bubble
moves faster than the mean flow. Our simulations reproduce analytical and
experimental predictions for the velocity threshold and the relative velocity
of the large bubble, demonstrating the utility of the CPM in foam rheology
studies.Comment: 10 pages, 3 figures. Replaced with revised version accepted for
publication in JSTA
Reversal of hepatorenal syndrome type 1 with terlipressin plus albumin vs. placebo plus albumin in a pooled analysis of the OT-0401 and REVERSE randomised clinical studies
Background
The goal of hepatorenal syndrome type 1 (HRS-1) treatment is to improve renal function. Terlipressin, a synthetic vasopressin analogue, is a systemic vasoconstrictor used for the treatment of HRS-1, where it is available. Aim
To compare the efficacy of terlipressin plus albumin vs. placebo plus albumin in patients with HRS-1. Methods
Pooled patient-level data from two large phase 3, randomised, placebo-controlled studies were analysed for HRS reversal [serum creatinine (SCr) value ≤133 μmol/L], 90-day survival, need for renal replacement therapy and predictors of HRS reversal. Patients received intravenous terlipressin 1–2 mg every 6 hours plus albumin or placebo plus albumin up to 14 days. Results
The pooled analysis comprised 308 patients (terlipressin: n = 153; placebo: n = 155). HRS reversal was significantly more frequent with terlipressin vs. placebo (27% vs. 14%; P = 0.004). Terlipressin was associated with a more significant improvement in renal function from baseline until end of treatment, with a mean between-group difference in SCr concentration of −53.0 μmol/L (P \u3c 0.0001). Lower SCr, lower mean arterial pressure and lower total bilirubin and absence of known precipitating factors for HRS were independent predictors of HRS reversal and longer survival in terlipressin-treated patients. Conclusions
Terlipressin plus albumin resulted in a significantly higher rate of HRS reversal vs. albumin alone in patients with HRS-1. Terlipressin treatment is associated with improved renal function
Phenotypically determined resistance of Neisseria gonorrhoeae to normal human serum: environmental factors in subcutaneous chambers in guinea pigs
Some gonococci obtained from human urethral exudate or from subcutaneously implanted chambers in guinea pigs show a resistance to killing by human serum which is lost on subculture in vitro after a few generations. The environmental factors which may influence the phenotypic expression of resistance to serum killing were investigated in guinea pig chambers and in chamber fluid in vitro. The redox potential in chambers before and after infection was lower than that of heart blood but conditions were not anaerobic; H2O2 increased the redox potential but did not decrease gonococcal serum resistance. The chambers were slightly alkaline before and after infection. When the concentration of glucose (depleted in infected chambers by the abundant polymorphonuclear cells) was restored to excess, the serum resistance of the gonococci was unaffected. Concentrations of free amino acids in chambers changed little during infection. Gonococci adapted to growth in chambers and subsequently rendered serum-sensitive by growing once on agar reverted to serum-resistance after 0.5 to 1 h incubation in chamber fluid in vitro at 37°C but not at 25°C or 4°C. After 16 to 24 h growth at 37°C, resistance was again lost. The reversion to serum resistance did not occur in a complex laboratory medium. Examination of the chamber fluid after growth of gonococci in vitro showed depletion of lactate, glutamine and proline
Diffusion Enhancement in a Periodic Potential under High-Frequency Space-Dependent Forcing
We study the long-time behavior of underdamped Brownian particle moving
through a viscous medium and in a systematic potential, when it is subjected to
a space-dependent high-frequency periodic force. When the frequency is very
large, much larger than all other relevant system-frequencies, there is a
Kapitsa time-window wherein the effect of frequency dependent forcing can be
replaced by a static effective potential. Our new analysis includes the case
when the forcing, in addition to being frequency-dependent, is space-dependent
as well. The results of the Kapitsa analysis then lead to additional
contributions to the effective potential. These are applied to the numerical
calculation of the diffusion coefficient (D) for a Brownian particle moving in
a periodic potential. Presented are numerical results, which are in excellent
agreement with theoretical predictions and which indicate a significant
enhancement of D due to the space-dependent forcing terms. In addition we study
the transport property (current) of underdamped Brownian particles in a ratchet
potential.Comment: RevTex 6 pages, 5 figure
Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12.
Although chemokines are well established to function in immunity and endothelial cell activation and proliferation, a rapidly growing literature suggests that CXC Chemokine receptors CXCR3, CXCR4 and CXCR7 are critical in the development and progression of solid tumors. The effect of these chemokine receptors in tumorigenesis is mediated via interactions with shared ligands I-TAC (CXCL11) and SDF-1 (CXCL12). Over the last decade, CXCR4 has been extensively reported to be overexpressed in most human solid tumors and has earned considerable attention toward elucidating its role in cancer metastasis. To enrich the existing armamentarium of anti-cancerous agents, many inhibitors of CXCL12-CXCR4 axis have emerged as additional or alternative agents for neo-adjuvant treatments and even many of them are in preclinical and clinical stages of their development. However, the discovery of CXCR7 as another receptor for CXCL12 with rather high binding affinity and recent reports about its involvement in cancer progression, has questioned the potential of "selective blockade" of CXCR4 as cancer chemotherapeutics. Interestingly, CXCR7 can also bind another chemokine CXCL11, which is an established ligand for CXCR3. Recent reports have documented that CXCR3 and their ligands are overexpressed in different solid tumors and regulate tumor growth and metastasis. Therefore, it is important to consider the interactions and crosstalk between these three chemokine receptors and their ligand mediated signaling cascades for the development of effective anti-cancer therapies. Emerging evidence also indicates that these receptors are differentially expressed in tumor endothelial cells as well as in cancer stem cells, suggesting their direct role in regulating tumor angiogenesis and metastasis. In this review, we will focus on the signals mediated by this receptor trio via their shared ligands and their role in tumor growth and progression
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