7 research outputs found
Algal-Derived Halogenated Sesquiterpenes from <i>Laurencia dendroidea</i> as Lead Compounds in Schistosomiasis Environmental Control
Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, Laurencia dendroidea, whose extracts demonstrated significant activity toward both Schistosoma mansoni parasites and their intermediate host snails Biomphalaria glabrata. In the present study, three seaweed-derived halogenated sesquiterpenes, (â)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against S. mansoni cercariae and B. glabrata embryos. Biomonitored fractioning of L. dendroidea extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos
ESCRITĂRIO MODELO ALBANO VOLKMER: ESCRITĂRIO DE ARQUITETURA E URBANISMO DE GESTĂO ESTUDANTIL VOLTADO PARA PROJETOS PARTICIPATIVOS
ESCRITĂRIO MODELO ALBANO VOLKMER: ESCRITĂRIO DE ARQUITETURA E URBANISMO DE GESTĂO ESTUDANTIL VOLTADO PARA PROJETOS PARTICIPATIVOS
Comparative analysis of anxiety and depression prevalence between individuals with and without inflammatory bowel disease
Rationale: Inflammatory bowel diseases â Crohn's Disease (CD) and Ulcerative Colitis (UC) â are chronic disorders associated, for several reasons, with psychological symptoms and stigmatization of patients. Aim: To compare individuals with and without inflammatory bowel diseases in relation to the prevalence of anxiety and depression. Method: The psychological aspect was analyzed using two globally validated questionnaires â the Patient Health Questionnaire (PHQ-9) and the General Anxiety Disorder questionnaire (GAD-7) â in addition to a sociodemographic questionnaire. Data collection was carried out in three groups, each one consisting of 100 individuals; the first comprising outpatients with a diagnosis of inflammatory bowel diseases, the second comprising outpatients without a diagnosis of inflammatory bowel diseases and the third by non-outpatients without a diagnosis of inflammatory bowel diseases. Results: The groups were similar regarding gender, ethnicity, marital status and tobacco use. As for social class, the IBD group showed a predominance of class E (46%), the outpatient group a predominance of class D (44%) and the non-outpatient group, class C (44%) (p < 0.001). The non-outpatient group also had a higher number of young individuals (mean = 36.69 years) (p < 0.001). There was a higher number of individuals with depression and anxiety in the IBD and outpatient control groups when compared to the non-outpatientsâ group (p < 0.001), but with no difference between the two first groups. There was a higher number of individuals with severe degree anxiety in the IBD group (36%) compared to the non-outpatientsâ group (8%) (p < 0.001). Conclusion: Greater severity and a prevalence of anxiety and depression were observed in the group with inflammatory bowel diseases. Resumo: Racional: Doenças inflamatĂłrias intestinais â Doença de Crohn (DC) e Retocolite Ulcerativa (RCU) â sĂŁo desordens crĂŽnicas associadas, por diversos fatores, a sintomas psicolĂłgicos e estigmatização dos portadores. Objetivo: Comparar indivĂduos portadores e nĂŁo portadores de doenças inflamatĂłrias intestinais em relação Ă prevalĂȘncia de ansiedade e depressĂŁo. MĂ©todo: O aspecto psicolĂłgico foi analisado atravĂ©s de dois questionĂĄrios mundialmente validados â o QuestionĂĄrio sobre SaĂșde do Paciente (PHQ-9) e o questionĂĄrio de Transtorno Geral de Ansiedade (GAD-7) â alĂ©m de um questionĂĄrio sociodemogrĂĄfico. A coleta foi realizada em trĂȘs grupos, cada um composto por 100 indivĂduos, sendo o primeiro composto por pacientes ambulatoriais com diagnĂłstico de doenças inflamatĂłrias intestinais, o segundo por pacientes ambulatoriais sem diagnĂłstico de doenças inflamatĂłrias intestinais e o terceiro por indivĂduos nĂŁo ambulatoriais sem diagnĂłstico de doenças inflamatĂłrias intestinais. Resultados: Os grupos foram semelhantes quanto a gĂȘnero, etnia, estado civil e uso de tabaco. Quanto Ă classe social, o grupo doenças inflamatĂłrias intestinais apresentou predominĂąncia de classe E (46%), o grupo Controle Ambulatorial predominĂąncia de classe D (44%) e o grupo Controle Parque de classe C (44%) (p < 0,001). O grupo controle parque teve tambĂ©m maior nĂșmero de indivĂduos jovens (mĂ©dia = 36,69 anos) (p < 0,001). Observou-se maior nĂșmero de indivĂduos com depressĂŁo e ansiedade nos grupos doenças inflamatĂłrias intestinais e Controle ambulatorial em comparação ao grupo Controle parque (p < 0,001), mas sem diferença entre os primeiros. Houve maior nĂșmero de indivĂduos com ansiedade grau severo no grupo DII (36%) em comparação ao grupo Controle parque (8%) (p < 0,001). ConclusĂŁo: No grupo portador de doenças inflamatĂłrias intestinais foi observada maior severidade e prevalĂȘncia de ansiedade e depressĂŁo
ANO IX, nĂșmero 18
Espaço e Economia: Revista Brasileira de Geografia EconĂŽmica dedica esta edição especial Ă segunda parte do DossiĂȘ CoronavĂrus