11,994 research outputs found
Cleaning data with Llunatic
Data cleaning (or data repairing) is considered a crucial problem in many database-related tasks. It consists in making a database consistent with respect to a given set of constraints. In recent years, repairing methods have been proposed for several classes of constraints. These methods, however, tend to hard-code the strategy to repair conflicting values and are specialized toward specific classes of constraints. In this paper, we develop a general chase-based repairing framework, referred to as Llunatic, in which repairs can be obtained for a large class of constraints and by using different strategies to select preferred values. The framework is based on an elegant formalization in terms of labeled instances and partially ordered preference labels. In this context, we revisit concepts such as upgrades, repairs and the chase. In Llunatic, various repairing strategies can be slotted in, without the need for changing the underlying implementation. Furthermore, Llunatic is the first data repairing system which is DBMS-based. We report experimental results that confirm its good scalability and show that various instantiations of the framework result in repairs of good quality
Minimal chordal sense of direction and circulant graphs
A sense of direction is an edge labeling on graphs that follows a globally
consistent scheme and is known to considerably reduce the complexity of several
distributed problems. In this paper, we study a particular instance of sense of
direction, called a chordal sense of direction (CSD). In special, we identify
the class of k-regular graphs that admit a CSD with exactly k labels (a minimal
CSD). We prove that connected graphs in this class are Hamiltonian and that the
class is equivalent to that of circulant graphs, presenting an efficient
(polynomial-time) way of recognizing it when the graphs' degree k is fixed
Splenomegaly impacts prognosis in essential thrombocythemia and polycythemia vera: A single center study
Splenomegaly is one of the major clinical manifestations of primary myelofibrosis and is common also in other chronic Philadelphia-negative myeloproliferative neoplasms, causing symptoms and signs and affecting quality of life of patients diagnosed with these diseases. We aimed to study the impact that such alteration has on thrombotic risk and on the survival of patients with essential thrombocythemia and patients with Polycythemia Vera (PV). We studied the relationship between splenomegaly (and its grade), thrombosis and survival in 238 patients with et and 165 patients with PV followed at our center between January 1997 and May 2019
Sublingual isosorbide dinitrate to improve technetium-99m-teboroxime perfusion defect reversibility.
Quantum baker maps with controlled-NOT coupling
The characteristic stretching and squeezing of chaotic motion is linearized
within the finite number of phase space domains which subdivide a classical
baker map. Tensor products of such maps are also chaotic, but a more
interesting generalized baker map arises if the stacking orders for the factor
maps are allowed to interact. These maps are readily quantized, in such a way
that the stacking interaction is entirely attributed to primary qubits in each
map, if each subsystem has power-of-two Hilbert space dimension. We here study
the particular example of two baker maps that interact via a controlled-not
interaction. Numerical evidence indicates that the control subspace becomes an
ideal Markovian environment for the target map in the limit of large Hilbert
space dimension.Comment: 8 page
Probing the Ultrastructure of Spheroids and Their Uptake of Magnetic Nanoparticles by FIBâSEM
Spheroids are 3D cellular systems largely adopted as model for high-throughput screening of molecules and diagnostics tools. Furthermore, those cellular platforms also represent a model for testing new delivery carries for selective targeting. The coupling between the 3D cell environment and the nanovectors can be explored at the macroscale by optical microscopy. However, the nanomaterial-cell interplay finds major action at the single cell and extracellular matrix level with nanoscale interactions. Electron microscopy offers the resolution to investigate those interactions; however, the specimen preparation finds major drawbacks in its operation time and preciseness. In this context, focused ion beam and scanning electron microscopy (FIBâSEM) allows for fast processing and high resolution of the cell-nanomaterial interface. Here, in fact, a novel approach is shown to prepare large-area 3D spheroid cell culture specimens for FIBâSEM. Sectioning procedures are explored to preserve the peculiar structure of spheroids and their interaction with magnetic nanovectors. The results pave the way for advanced investigations of 3D cellular systems with nano and micromaterials relevant to tissue engineering, bioelectronics, and diagnostics
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i
Glioblastoma multiforme (GB) is the most malignant primary brain tumor in humans, with an overall survival of approximatively 15 months. The molecular heterogeneity of GB, as well as its rapid progression, invasiveness and the occurrence of drug-resistant cancer stem cells, limits the efficacy of the current treatments. In order to develop an innovative therapeutic strategy, it is mandatory to identify and characterize new molecular players responsible for the GB malignant phenotype. In this study, the RNA-binding ubiquitin ligase MEX3A was selected from a gene expression analysis performed on publicly available datasets, to assess its biological and still-unknown activity in GB tumorigenesis. We find that MEX3A is strongly up-regulated in GB specimens, and this correlates with very low protein levels of RIG-I, a tumor suppressor involved in differentiation, apoptosis and innate immune response. We demonstrate that MEX3A binds RIG-I and induces its ubiquitylation and proteasome-dependent degradation. Further, the genetic depletion of MEX3A leads to an increase of RIG-I protein levels and results in the suppression of GB cell growth. Our findings unveil a novel molecular mechanism involved in GB tumorigenesis and suggest MEX3A and RIG-I as promising therapeutic targets in GB
Micro-beam and pulsed laser beam techniques for the micro-fabrication of diamond surface and bulk structures
Micro-fabrication in diamond is involved in a wide set of emerging
technologies, exploiting the exceptional characteristics of diamond for
application in bio-physics, photonics, radiation detection. Micro ion-beam
irradiation and pulsed laser irradiation are complementary techniques, which
permit the implementation of complex geometries, by modification and
functionalization of surface and/or bulk material, modifying the optical,
electrical and mechanical characteristics of the material. In this article we
summarize the work done in Florence (Italy) concerning ion beam and pulsed
laser beam micro-fabrication in diamond.Comment: 14 pages, 5 figure
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