Ecosystem Services Valuation for the Sustainable Land Use Management by Nature-Based Solution (NbS) in the Common Agricultural Policy Actions: A Case Study on the Foglia River Basin (Marche Region, Italy).

Agricultural land is a very important ecosystem that provides a range of services like food, maintenance of soil structure, and hydrological services with high ecological value to human wellbeing Ecosystem Services (ESs). Understanding the contribution of different agricultural practices to supply ESs would help inform choices about the most beneficial land use management. Naturebased Solutions (NbS) are defined by IUCN (International Union for Conservation of Nature) as actions to protect, sustainably manage and restore natural or modified ecosystems, which address societal challenges (e.g., climate change, food and water security, or natural disasters) effectively and adaptively, while simultaneously providing human wellbeing and biodiversity benefits. Some actions farmers can implement in the new Rural Development Programs (RDP 2021–2022 and 2023–2027) can be considered as NbS and could affect the quantity, quality, and time of some ESs related to water regulation and supply, N adsorption and erosion protection. This study aims to evaluate these ESs in different scenarios in the upper Foglia river basin (Italy) and at a local scale (farming), and to highlight the issue to compensate farmers for the production of public goods which benefit the whole society (ESs) by the implementation of RDP’s actions. These scenarios highlight how actions have positive effects on ecosystem services and their economic value related to land use management, on maintaining agricultural practices by integrating Water Frame Directive (2000/60/EC), Directive 2007/60/EC on the management of flood risks and highlighting the potential role of farmers in a high diversity landscape. This study highlights a new way to evaluate the processes of natural capital in the production of public goods, which benefits the whole society (ESs), by emphasizing the economic and environmental role of farmers in producing them and putting on the table data to trigger a PES (Payment for Ecosystem Services) mechanism. To facilitate decision making, robust decision support tools are needed, underpinned by comprehensive cost-benefit analyses and spatially modeling in which agriculture can be a strategic sector to optimize food production and environmental protection in harmony with the Farm to Fork (F2F) strategy

GEOSTATISTICAL METHODS TO MEASURE THE NATURE 2000 HABITAT INSULARIZATION IN ITALY

It is interesting to notice how Nature 2000 is described as an instrument of “widespread ecological network throughout the EU territories”, insisting in a definitional imprecision that has been dragging on for more than twenty years, and that was often, also authoritatively, criticized by many. Undoubtedly, many of these elements constitute the focal point of local ecological networks for species conservation importance, but their functionality depends on equally undoubtedly by the presence of ecologically permeable matrices that enable the biotic flows dynamics. The Italian Regions are the subjects of this study, as an expression of homogeneous forms of territorial government and as a reference on the administrative level for the implementation of Community policies for Nature 2000 network. The method followed in the work refers to an evaluate spatial fragmentation conditions methodology and the SCIs are the evaluated patches, which have a high dispersion on the national territory. This research has been conducted to show how the central issue of habitat and species conservation is still currently the fragmentation provoked by mobility infrastructures and urban planning Keyword

Numb Is an Endocytic Protein

Numb is a protein that in Drosophila determines cell fate as a result of its asymmetric partitioning at mitosis. The function of Numb has been linked to its ability to bind and to biologically antagonize Notch, a membrane receptor that also specifies cell fate. The biochemical mechanisms underlying the action of Numb, however, are still largely unknown. The wide pattern of expression of Numb suggests a general function in cellular homeostasis that could be additional to, or part of, its action in fate determination. Such a function could be endocytosis, as suggested by the interaction of Numb with Eps15, a component of the endocytic machinery. Here, we demonstrate that Numb is an endocytic protein. We found that Numb localizes to endocytic organelles and is cotrafficked with internalizing receptors. Moreover, it associates with the appendage domain of α adaptin, a subunit of AP2, a major component of clathrin-coated pits. Finally, fragments of Numb act as dominant negatives on both constitutive and ligand-regulated receptor-mediated internalization, suggesting a general role for Numb in the endocytic process

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

The biological antagonism between Notch and Numb controls the proliferative/differentiative balance in development and homeostasis. Although altered Notch signaling has been linked to human diseases, including cancer, evidence for a substantial involvement of Notch in human tumors has remained elusive. Here, we show that Numb-mediated control on Notch signaling is lost in ∼50% of human mammary carcinomas, due to specific Numb ubiquitination and proteasomal degradation. Mechanistically, Numb operates as an oncosuppressor, as its ectopic expression in Numb-negative, but not in Numb-positive, tumor cells inhibits proliferation. Increased Notch signaling is observed in Numb-negative tumors, but reverts to basal levels after enforced expression of Numb. Conversely, Numb silencing increases Notch signaling in normal breast cells and in Numb-positive breast tumors. Finally, growth suppression of Numb-negative, but not Numb-positive, breast tumors can be achieved by pharmacological inhibition of Notch. Thus, the Numb/Notch biological antagonism is relevant to the homeostasis of the normal mammary parenchyma and its subversion contributes to human mammary carcinogenesis