Vascular density.

<p>Respresentative picutures of Lectin staining of the borderzone of a CMCP treated animals (A) and a placebo animal (B)</p

QPCR.

<p>A. QPCR shows presence of genomic pig DNA (Gapdh) in all pig tissues treated with CMPC or placebo and absence of pig DNA in the sample containing human CMPCs (Human) and the negative control (Neg) containing H2O used for PCR. B. Human genomic DNA (HLA-DMA) was detected in the sample containing human CMPCs (Human), but was absent in all the pig tissues (CMPC and Placebo) and the negative control (Neg) containing H2O used for PCR</p

Fibrosis.

<p>Representative picture of a picrosirius red stained borderzone slide (A. bright field, B. polarized light) and a higher magnification of a picrosirius red stained slides isolated from the infarct area (C,D), borderzone (E,F) and remote area (G,H) of the left ventricle (bright field C,E,G, polarized light (D,F,H).</p

Functional outcome measurements by PV loop.

<p>Mean and SD for PVloop parameters. EDV End diastolic volume, ESV End systolic volume, EF Left ventricular ejection fraction, ESPVR End systolic pressures volume relationship, EDPVR end diastolic pressure volume relationship. Placebo n = 8, cell n = 7 for ESV, EDV and EF, n = 6 per group for ESPVR, EDPVR and V0.</p

Functional measurements by MRI of cell- and placebo treated animals at follow up.

<p>Individual data and mean with SD, n = 8 per group. EF Left ventricular ejection fraction, EDV End diastolic volume, ESV End systolic volume.</p

Functional measurements by echocardiography.

<p>Mean and SD, n = 8 per group. FAS Fractional area shortening, FS Fractional shortening, sWT Septal wall thickening at the level of the apex.</p

Infarct size.

<p>Representative pictures of TTC stained heart slice and LGE image of the same animal. Mean (±SD) infarct size of CMPC and placebo animals were 14.6 ± 2,5% and 13.8 ± 3.9% of the left ventricle based on TTC staining and 17.5 ± 3.8 and 18.0 ± 4.5 based on LGE imaging.</p