Management of periodontic-endodontic lesion in aggressive periodontitis-9 months follow-up: Report of a case

The case report describes the successful management of a right mandibular first molar with a periodontic-endodontic lesion in a 28-year-old female with aggressive periodontitis. The treatment carried out to treat this condition was primarily by endodontic treatment followed by regenerative periodontal therapy where the bone graft along with platelet-rich fibrin was used. The prognosis of the tooth was fair at the baseline. Along with the above treatments, patient's compliance played a major role in improving the prognosis of the tooth. Hence, treating periodontic-endodontic lesion is not a difficult task if all the protocols were being followed during the length of the treatment

Assessment of periodontal abscess among diabetic patients visiting a dental college -a retrospective study

Periodontitis is a chronic inflammatory disease characterised by destruction of supporting structures of teeth.Diabetes mellitus is a syndrome of abnormal carbohydrate, fat and protein metabolism that result in acute, chronic complications due to the absolute or lack of insulin.The progression of periodontal disease is influenced by factors like microorganism, host response, systemic background and genetic makeup of the host.1 Chronic hyperglycemia results in production of advanced glycation end substances (AGEs) in the tissues, which have protean effects on the periodontal microenvironment.The aim of the study was to assess the periodontal abscess among diabetic patients visiting dental college. A retrospective data of all the patients reported for periodontal therapy to dental college was collected. The data was extracted from the patients records. Data segregation was done based on age, gender,site of periodontal abscess, blood sugar value probing depth, clinical attachment loss and mobility. After data collection statistical analysis was done in IBM SPSS software version 20. A total 50 diabetic patients with periodontal abscess were evaluated in this study and it showed about 64% of males and 36% % of females with periodontitis had diabetes. The most common age group that was affected was 36-45 years by 36%. The most prevalent site with periodontal abscess is lower left posterior by 24%. Probing depth of 5mm was seen mostly in patients with diabetes and periodontitis (34%). Clinical attachment loss of 6mm was seen mostly in patients with diabetes and periodontitis (50%). Grade 2 mobility was seen predominantly in patients with abscess(48%). Patients with periodontal abscess had blood sugar level above 200mg/dl by 50%. The chi square test was performed to determine the correlation between age of the periodontitis patients and the random blood sugar levels, the P value obtained was 0.045 (p<0.05) statistically significant. The most prevalent age group that was affected with periodontal abscess was between 36-45 years. The males were more affected with periodontal abscess among diabetics. The predominant site involved with periodontal abscess was the lower left posterior region. The association between the blood sugar levels and age was significant statistically

Role of sulfiredoxin in systemic diseases influenced by oxidative stress

Sulfiredoxin is a recently discovered member of the oxidoreductases family which plays a crucial role in thiol homoeostasis when under oxidative stress. A myriad of systemic disorders have oxidative stress and reactive oxygen species as the key components in their etiopathogenesis. Recent studies have evaluated the role of this enzyme in oxidative stress mediated diseases such as atherosclerosis, chronic obstructive pulmonary disease and a wide array of carcinomas. Its action is responsible for the normal functioning of cells under oxidative stress and the promotion of cell survival in cancerous cells. This review will highlight the cumulative effects of sulfiredoxin in various systemic disorders with a strong emphasis on its target activity and the factors influencing its expression in such conditions

Methodological considerations in salivary proteomics for periodontal research-A review

The diagnosis and management of periodontal diseases can be enhanced by the identification of biomolecules which can predict disease susceptibility, indicate current disease activity, and monitor response to therapy. Salivary proteomics is a major avenue in the ongoing search for a biomarker in periodontal research. Saliva is a valuable diagnostic vehicle which “mirrors” oral and systemic health and disease. Standardized methods of saliva sampling and processing will increase diagnostic test accuracy and decrease bias in measurements. Prominent databases such as PubMed/Medline, PMC, Scopus, and Google Scholar were searched and literature evidence from January 2000 till September 2022 were studied to identify the methodological considerations employed in salivary proteomics for periodontal research. Evidence and recommendations in this regard were collated into this narrative review. The methods of saliva collection and processing presented in this review will help researchers conduct salivary proteomic studies with standardized protocols