Self rated performance and perceived workload among the public health nurses of Kerala

The study on workload of public health nurses conducted during 2011-12 with the questions on three aspects of workload namely, role overload, role stagnation, self role distance (RODS). The study was conducted in five districts of Kerala using a self administered questionnaire during 2011-12. For data collection 1238 public health nurses were contacted. Of 1238 only 1225 have responded the question on self rated performance. Majority of them scored well in self rated performance, while many of them have scored less in all three aspects of workload namely RODS. This suggests even the public health nurses feel they have performed satisfactorily, but still they feel the over load in terms of role overload, role stagnation and self role distance. This is further justified by the findings on perceived consequences of poor performance. Many have expressed poor performance will not affect their career. This is because even a better performed worker does not get any reward in terms of promotion or poor performed does not get transferred or punished. These findings suggest that government has to take necessary action to reduce the workload and introduce more incentives for better performance

Electrode Position and Current Amplitude Modulate Impulsivity after Subthalamic Stimulation in Parkinsons Disease—A Computational Study

Background: Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) is highly effective in alleviating motor symptoms of Parkinson’s disease (PD) which are not optimally controlled by dopamine replacement therapy. Clinical studies and reports suggest that STN-DBS may result in increased impulsivity and de novo impulse control disorders (ICD)Objective/Hypothesis: We aimed to compare performance on a decision making task, the Iowa Gambling Task (IGT), in healthy conditions (HC), untreated and medically-treated PD conditions with and without STN stimulation. We hypothesized that the position of electrode and stimulation current modulate impulsivity after STN-DBS.Methods: We built a computational spiking network model of basal ganglia (BG) and compared the model’s STN output with STN activity in PD. Reinforcement learning methodology was applied to simulate IGT performance under various conditions of dopaminergic and STN stimulation where IGT total and bin scores were compared among various conditions.Results: The computational model reproduced neural activity observed in normal and PD conditions. Untreated and medically-treated PD conditions had lower total IGT scores (higher impulsivity) compared to HC (P<0.0001). The electrode position that happens to selectively stimulate the part of the STN corresponding to an advantageous panel on IGT resulted in de-selection of that panel and worsening of performance (P<0.0001). Supratherapeutic stimulation amplitudes also worsened IGT performance (P<0.001). Conclusion(s): In our computational model, STN stimulation led to impulsive decision making in IGT in PD condition. Electrode position and stimulation current influenced impulsivity which may explain the variable effects of STN-DBS reported in patients

Novel Face-Name Paired Associate Learning and Famous Face Recognition in Mild Cognitive Impairment: A Neuropsychological and Brain Volumetric Study

Purpose: To assess visual associative learning and famous face recognition ability among subjects with stable amnestic mild cognitive impairment (MCI) relative to early stage dementia due to Alzheimer’s disease (AD) and cognitively normal healthy controls (NC) and to correlate these differences with volumetric changes on MRI. Methods: A hospital-based cross-sectional observational study was conducted on 61 participants. The subjects underwent neuropsychological evaluation, including validated newly designed tests for novel face-name paired association learning recall and famous face recognition. MRI volumetry was done on a subset of patients to ascertain the topographical patterns of volume loss. Results: There were significant differences in performance on free recall for face-name paired associate learning in MCI (n = 22) compared to NC (n = 20) (p &#x3c; 0.001) and MCI compared to AD (n = 19; p &#x3c; 0.001). Significant differences were also noted in scores on the famous personalities test between MCI and NC (p = 0.007), and MCI and AD (p = 0.032). The free recall component of face-name pair associative learning significantly correlated with left cuneus (p = 0.005; r = 0.833) and right cuneus (p = 0.003; r = 0.861) volume in AD with no significant correlation among MCI and NC cohorts. Conclusions: Novel and semantically familiar face-name associative recalls are significantly impaired in MCI, and these potentially predate the MRI volumetric changes in MCI. Our findings expand the spectrum of recall deficits in MCI

Risk Assessment tool for Religious Mass Gathering Events of India

ObjectiveTo develop a risk assessment tool to assess the public health and environmental risks associated with religious mass gathering events of Tamil Nadu, a state in the southern part of IndiaIntroductionIn spite of the fact that mass gatherings are an undeniably regular element of our society attended by huge crowds yet such occasions are not very well understood. Even though such gatherings are accumulations of "well people", vast number of people associated with mass gatherings can put a serious strain on the entire health care system1.The public health implications of mass gathering events include a potential increased risk for disease transmission because of the variability and mobility of those attending the event and increased media attention. Risk assessment for mass gathering events is crucial to identify the potential health hazards which aids in planning and response activities specific to the event2. Preparing for mass gatherings offer an opportunity to improve health service delivery, enhance health promotion and strengthen public health systems3.In India, many of the religious festivals are observed with mass gatherings and prayers. Large crowd participate in such festivals as participants to observe the unique rituals and also as spectators. Literature indicates that in India, we might be well equipped for response activities but the scientific concept of risk assessment i.e., to understand the existing risks, identify the risks, characterize the risks and plan for risk reduction strategies accordingly are at an infant stage .The little that has been done in the field of mass gatherings has generally focused on description of preparedness activities of single event, crowd control, prevention of stampedes with little attention to public health preparedness. The present project is an attempt to systemize the process of risk assessment by developing a risk assessment tool consisting of characteristics peculiar to planned religious mass gatherings of Indian context.MethodsQualitative approach was followed to identify the risks associated with mass gathering events and to identify the domains and items to be included in the risk assessment tool. Firstly, an extensive review of literature about the risks associated with the mass gathering events was done. Secondly, Key Informants (n=20) involved in planning and management of religious mass gathering events in the State of Tamil Nadu, India were purposively identified and interviewed using a semi structured interview guide. Principle of redundancy was followed. Content/Thematic analysis was done using Atlas.ti software. Currently, the project is in the phase of obtaining content validity of the developed tool. Followed by this, a mobile application based upon the validated tool will be developed which will be further field tested for feasibility in a selected mass gathering event in Tamil Nadu. Using a self administered content validity questionnaire, the experts will be asked to assess the relevance of the items of the tool. Agreement proportions between the experts will be calculated. S-CVI (Scale Content Validity Index), index for inter-rater agreement (agreement proportion) and Kappa agreement coefficient will be calculated.ResultsA sum total of 48 unique health risks have been identified. Stampedes, fire accidents, structural collapse, drowning, outbreak of communicable diseases, exacerbation of existing medical illnesses (like cardiac diseases, asthma etc) etc are the some of the health risks identified. Six domains (characteristics related to event, participant, environment, disaster preparedness, medical service preparedness and pre event planning activities) and 21 items have been generated from the content analysis of key informant interviews and literature review.ConclusionsSome special events and unforeseen events occur in places of mass gatherings besides fixed places of worshipping .Such events cause more damage to human beings and property. Special events like idol procession, chariot pulling, fire walking, animal sacrificing happen pulling larger crowds within the mass gatherings. In order to inform all planning and delivery activities it is essential to understand the mass gathering context and risk assessments. This tool can be used by public health managers to identify key public health and environmental risks at the planning stage before the event takes off. At the planning stage, use of this tool will help in putting the required measures in place in order to address the potential risks identified. The tool can be used as a guiding instrument during and after the event as well. The investigators further plan to develop a mobile based app from this risk assessment tool and test it out in a selected mass gathering event of the state of Tamil Nadu located in southern part of India. Feedback from public health managers about the mobile based risk assessment tool can be instrumental in further modifying the tool. By contributing to public health preparedness activities during mass gathering events in a country with poor resources like India, this research activity is an initiative that is expected to lead to health systems strengthening.References1. Arbon P. The development of conceptual models for mass-gathering health. Prehospital and Disaster Medicine. 2004 Sep;19(3):208-12.2. World Health Organization. Public health for mass gatherings: Key considerations. Geneva: WHO; 2015.3. Tam JS, Barbeschi M, Shapovalova N, Briand S, Memish ZA, Kieny MP. Research agenda for mass gatherings: a call to action. The Lancet infectious diseases. 2012 Mar 31; 12(3):231-9

Evolution of Morphology and Microstructure in Electrodeposited Nanocrystalline Al–Mg Alloy Dendrites

Nanocrystalline Al–Mg dendrites were fabricated through galvanostatic electrodeposition. Initially feather-like morphology was formed exhibiting morphological evolution to smooth globules at its tips. With eventual deposition, rough globules formed over the smooth ones. The feather-like and smooth globules possessed supersaturated face centered cubic (fcc)–Al(Mg) phase with ~7 and ~20 at.% Mg respectively. The rough globules contained hexagonal close packed (hcp)–Mg(Al) phase with ~80 at.% Mg. Microstructural examinations revealed that the feather-like and rough globules possessed grain sizes of ~42 ± 15 and ~36 ± 12 nm respectively. The region, which exhibited morphological evolution from feather-like to smooth globules, possessed ~16 ± 7 nm grain size. The observed microstructural and compositional features were attributed to the local current density values. The formation of the Al–Mg dendrites is discussed in this paper

An assessment of the clinical equivalence of valproate chrono and extended release divalproex formulations

<b>Objective:</b> No guideline currently exists to choose the clinically equivalent dose of divalproex extended release (ER) formulation while switching over from valproate chrono formulation. To address this issue, we evaluated the serum valproate concentration following switch over from valproate chrono to divalproex ER in persons with epilepsy. <b> Materials and<i> </i> Methods</b>:<i> </i> An open label study was conducted in two parts, each for a period of two months. During Part I, patients on regular twice-daily dose of valproate chrono were switched over to once daily divalproex ER (DESVAL ER^&#x00AE; ) based on the dose escalation recommended when switching over from divalproex DR to ER formulation as the guideline. During Part II, we switched from valproate chrono to divalproex ER with same dosage. Serum valproate concentration, seizure frequency and side effects were assessed serially for two months after changeover and compared with the preswitch data. Results:<i> </i> During Part I, compared to the baseline level, there was a significant increase in mean serum valproate level at two months (67.0 &#x00B1; 28.4 mg/ml versus 91.9 &#x00B1; 3.5 mg/ml, <i> P</i> 0.004). With the same dose conversion during Part II, the mean valproate level did not significantly differ before and after the switch (81.5 mg/dl versus 85.7 mg/dl, <i> P</i> 0.08). The mean monthly seizure frequencies and serum ammonia levels did not change during either part. No significant adverse effects occurred. <b> Conclusion:</b> The results of this open label study with small number of patients need to be replicated among larger patient sample through a randomized control design before recommending same dose conversion from valproate chrono to divalproex ER without change in efficacy and tolerability

Assessment of Endocrine Disruption Potential of Selected Pharmaceuticals Using an In-vitro Assay

Contamination of water bodies by pharmaceuticals has recently received much attention. Even at low concentration, pharmaceuticals can disrupt the natural hormonal responses (endocrine disruptors) leading to a multitude of toxicological effects in aquatic life. In the current study, the estrogenic effect of selected pharmaceuticals was evaluated using the E-Screen assay, which quantifies the cell proliferation of estrogen responsive MCF-7 breast cancer cells with respect to 17β- estradiol. In this assay, 17-α ethinylestradiol and acetaminophen were found to yield a strong and weak estrogenic response, respectively, while diclofenac and carbamazepine caused antagonistic effect. Validity of the in- vitro assay was confirmed when these pharmaceuticals did not generate any response in the estrogen receptor negative breast cancer cell line, MDA-MB-231. Based on the level of residual pharmaceuticals reported in wastewater effluents in Mumbai, the results of this study indicate that estrogenic effects may be expected in wastewater effluent

Hyponatremia after aneurysmal subarachnoid hemorrhage: Implications and outcomes

Background: Hyponatremia is the most common electrolyte abnormality seen in patients with aneurysmal SAH. Clinically significant hyponatremia (Serum Sodium <131 mEq/L) which needs treatment, has been redefined recently and there is a paucity of outcome studies based on this. This study aims to identify the mean Serum Sodium (S.Na+) level and its duration among inpatients with SAH and to identify the relationship between hyponatremia and the outcome status of patients undergoing surgery for SAH. Materials and Methods: This outcome study is undertaken in the department of neurosurgery, The Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala. Medical records of all patients with SAH from 1st January to 31st July 2010 were reviewed. Preoperative status was assessed using World Federation of Neurosurgical Societies (WFNS) grading system. Discharge status was calculated using the Glasgow outcome score scale. Results: Fifty nine patients were included in the study and 53 (89.8%) of them have undergone surgical treatment. Hyponatremia was observed in 22 of 59 patients (37%). The mean Sodium level of hyponatremic patients was 126.97 mEq/L for a median duration of two days. Glasgow outcome score was good in 89.8% of patients. We lost two patients, one of whom had hyponatremia and vasospasm. Conclusion: Hyponatremia is significantly associated with poor outcome in patients with SAH. Anticipate hyponatremia in patients with aneurysmal subarachnoid hemorrhage, timely detect and appropriately treat it to improve outcome. It is more common in patients who are more than 50 years old and whose aneurysm is in the anterior communicating artery. Our comprehensive monitoring ensured early detection and efficient surgical and nursing management reduced morbidity and mortality

Frequent seizures and polytherapy can impair quality of life in persons with epilepsy

CONTEXT: Careful evaluation of pharmacotherapy, seizure control and quality of life (QOL) are helpful in improving epilepsy care but such data are relatively meager from developing countries. AIMS: To audit pharmacotherapy, seizure control and QOL in persons with epilepsy and to identify factors associated with impaired QOL. SETTINGS AND DESIGN AND MATERIALS AND METHODS: The study was carried out using a cross-sectional design in the setting of a tertiary care epilepsy center in India. Persons with epilepsy with >12 months follow-up at this Center and aged >16 years were eligible for enrollment. Persons with other disabilities or pregnancy were excluded. Subjects were interviewed with a standard questionnaire and an adapted version of Quality of Life in Epilepsy - 31 (QOLIE-31). Data pertaining to treatment at the time of referral to this center was extracted from medical records. STATISTICAL ANALYSIS USED: Chi-square test, analysis of variance and multiple regression analysis were carried out for statistical significance. RESULTS: One hundred and twelve patients with epilepsy (59 males, mean age 31.2±10.7 years) were included. Forty-seven (42%) persons had Generalized Epilepsy (GE) and 65 persons (58%) had Localization-Related Epilepsy (LRE). At entry 24 persons (21.4%) were not on treatment and 59 persons (64.8%) had frequent seizures. At last follow-up 64 persons (57.1%) were seizure-free, 83 persons (74.1%) were on monotherapy and 29 were (25.9%) on polytherapy. Cost of drug at entry was INR 2276 (monotherapy) and INR 3629 (polytherapy) (45 INR = 1 USD). At the time of last follow-up, it was 1898 and 4929 respectively. QOLIE-31 Total Score (TQOL) ranged from 22.6 to 94.4 (mean 68.0 ± 15.8). Multiple regression analysis showed significant correlation between low TQOL score and polytherapy (P=0.002) and occurrence of one or more seizures per month (P=0.001). CONCLUSIONS: Frequent seizures and polytherapy are associated with lower QOL in persons with epilepsy