14 research outputs found
N-(2-Chloro-2-nitro-1-phenylpropyl)-4-methylbenzenesulfonamide
In the title compound, C16H17ClN2O4S, the dihedral angle between the phenyl and benzene rings is 19.4 (2)°. The crystal packing is stabilized by intermolecular N—H⋯O hydrogen bonds, as well as by intra- and intermolecular C—H⋯O hydrogen bonds
Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
Radical reactions are powerful in creating carbon–carbon and carbon–heteroatom bonds. Designing one-pot radical reactions with cascade transformations to assemble the cyclic skeletons with two new functional groups is both synthetically and operationally efficient. Summarized in this paper is the recent development of reactions involving radical addition and cyclization of dienes, diynes, enynes, as well as arene-bridged and arene-terminated compounds for the preparation of difunctionalization cyclic compounds. Reactions carried out with radical initiators, transition metal-catalysis, photoredox, and electrochemical conditions are included
Recent Developments on Five-Component Reactions
Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included
Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
Radical reactions are powerful in creating carbon–carbon and carbon–heteroatom bonds. Designing one-pot radical reactions with cascade transformations to assemble the cyclic skeletons with two new functional groups is both synthetically and operationally efficient. Summarized in this paper is the recent development of reactions involving radical addition and cyclization of dienes, diynes, enynes, as well as arene-bridged and arene-terminated compounds for the preparation of difunctionalization cyclic compounds. Reactions carried out with radical initiators, transition metal-catalysis, photoredox, and electrochemical conditions are included
Radical Cyclization-Initiated Difunctionalization Reactions of Alkenes and Alkynes
Radical reactions are powerful in the synthesis of diverse molecular scaffolds bearing functional groups. In previous review articles, we have presented 1,2-difunctionalizations, remote 1,3-, 1,4-, 1,5-, 1,6- and 1,7-difunctionalizations, and addition followed by cyclization reactions. Presented in this paper is radical cyclization followed by the second functionalization reaction. The second functionalization could be realized by atom transfer reactions, radical or transition metal-assisted coupling reactions, and reactions with neutral molecules, cationic and anionic species
Palladium-catalyzed aziridination of alkenes using N,N-dichloro-p-toluenesulfonamide as nitrogen source
N,N-Dichloro-p-toluenesulfonamide (TsNCl2) was found to be an efficient nitrogen source for the aziridination of unfunctionalized alkenes using palladium catalysts. Among the palladium salts, palladium acetate was the most effective catalyst for this reaction. A variety of alkenes were reacted at room temperature with TsNCl2 to form the desired aziridines in moderate to good yields. This method can complement our previous protocol which is limited to the use of electron-deficient α,β -unsaturated alkenes. Graphical abstract N,N-Dichloro-p-toluenesulfonamide (TsNCl2) was found to be an efficient nitrogen source for the aziridination of unfunctionalized alkenes using palladium catalysts. Among the palladium salts, palladium acetate was the most effective catalyst for this reaction. A variety of alkenes were reacted at room temperature with TsNCl2 to form the desired aziridines in moderate to good yields. This method can complement our previous protocol which is limited to the use of electron-deficient α,β -unsaturated alkenes
Soft Error Sensitivity Analysis Based on 40 nm SRAM-Based FPGA
Soft errors induced by radiation are the major reliability threat for SRAM-based field-programmable gate arrays (FPGAs). A more detailed analysis of the soft error sensitivity of the 40 nm SRAM-based FPGA was performed. Experimental methods for the configurable logic module, configure memory cells, and block RAM have been introduced for measuring the single event effects (SEEs) induced by alpha particles using a 241Am radiation source. The single event upset (SEU) and single event functional interrupt (SEFI) cross sections of different functional blocks have been calculated to discuss the failure mechanisms of the FPGA. The SEEs test results for the FPGA device based on the 40 nm CMOS process are significant
Synthesis of Pyrrole via a Silver-Catalyzed 1,3-Dipolar Cycloaddition/Oxidative Dehydrogenative Aromatization Tandem Reaction
Pyrroles
are an important group of heterocyclic compounds with
a wide range of interesting properties, which have resulted in numerous
applications in a variety of fields. Despite the importance of these
compounds, there have been few reports in the literature pertaining
to the synthesis of pyrroles from simple alkenes using a one-pot sequential
1,3-dipolar cycloaddition/aromatization reaction sequence.
Herein, we report the development of a benzoyl peroxide-mediated oxidative
dehydrogenative aromatization reaction for the construction of pyrroles.
We subsequently developed a one-pot tandem reaction that combined
this new method with a well-defined silver-catalyzed 1,3-dipolar cycloaddition
reaction, thereby providing a practical method for the synthesis of
multisubstituted pyrroles from easy available alkenes. The mechanism
of this oxidative dehydrogenative aromatization reaction was also
examined in detail