Performance of Circular Footing on Expansive Soil Bed Reinforced with Geocells of Chevron Pattern

Results from laboratory model tests performed on circular footing are presented in this paper to understand the performance of geocell reinforced expansive soil. Naturally occurring expansive soil was used in this study as subsoil. Geocells of chevron pattern fabricated from geotextile made up of polypropylene were used to reinforce the soil bed. The parameters studied in this testing program were the placement depth of the geocell mattress, pocket size of geocell and the height of geocell mattress. Contrary to other researchers; the improvement in the performance of reinforced bed is evaluated at a settlement level equal to the failure settlement of unreinforced soil bed. The performance of reinforced bed is evaluated through two non-dimensional factors viz. bearing capacity improvement factor (If) and settlement reduction factor (PRS%). Test results indicated that with the introduction of geocell as reinforcement, a substantial improvement in bearing capacity and decrease in footing settlement can be achieved. Bearing capacity of reinforced bed increases by more than 200% and 81% reduction in footing settlement was achieved by using geocell mattress of optimal dimensions and placing it just below the footing base

Study on the Swelling Behavior of Clayey Soil Blended with Geocell and Jute Fibre

Expansive soils like clays undergo swelling that can both be detrimental and acceptable in different applications. In the Northern part of India, especially Delhi region, natural soils containing clays & clayey sands support most of the buildings. Mechanically stabilized clays mixed with sand are used for local earthwork construction such as roads and landfills. Exact understanding of the swelling behaviour of such soils is a pre-requisite before the start of any construction projects. In this paper the swelling behaviour of clayey soil reinforced with geocell & Jute fibres has been presented. The laboratory investigations include one dimensional swelling tests using California Bearing Ratio (CBR) mould to study the swelling properties for different mix proportions. The maximum decrease in swelling potential of Geocell reinforced specimens was observed at fibre content of 0.80 percent and 40mm fibre length, beyond which increase in the swelling potential and swelling pressure has been observed. With this optimal reinforcement, a reduction of 71.24 percent in swelling and 41.10 percent in swelling pressure has been observed as compared to unreinforced soils. The study provides a solution towards the treatment of expansive soils before starting any construction activity over such soils and a step towards mitigating disasters related to infrastructure facilities grounded on expansive soils. Doi: 10.28991/cej-2021-03091728 Full Text: PD

Exploring the Potential of Curry Leaves for their Therapeutic Action

Curry leaves (Murryakoenigii), which are valued for their aromatic flavour, have been mainstay of Indian cuisine for ages. These leaves are becoming more well known for their potential to affect metabolic pathways in additional to their gastronomic value. The molecular mechanistic potential of curry leaves in relation to metabolic control is examined in this abstract. Curry leaves contain a variety of bioactive substance, such as antioxidant, anti-inflammatory agent, and substance that modulate insulin sensitivity, which have potential to have an effect on crucial metabolic processes. Their contribution to the management of oxidative stress, inflammation, blood sugar, cholesterol, weight, gut health, liver function, thermogenesis, and appetite regulation is discussed in this work. Although encouraging, more study is necessary to complete clarify the mechanism of action and to determine the efficacy of curry leaves in metabolic disorder

SYNTHESIS AND EVALUATION OF SOME BENZOTHIAZOLE DERIVATIVES AS ANTIDIABETIC AGENTS

Objective: The objective of the present research investigation involves synthesis and biological evaluation of antidiabetic activity of benzothiazole derivatives.Methods: A novel series of benzothiazole derivatives 7(a-l) were synthesised and synthesised compounds were characterised for different physical and chemical properties like molecular formula, molecular weight, melting point, percentage yield, Rf value, IR, 1HNMR, 13CNMR and mass spectroscopy. The newly synthesised benzothiazole derivatives were subsequently assayed in vivo to investigate their hypoglycemic activity by the alloxan-induced diabetic model in rats. Results: All the synthesised derivatives showed significant biological efficacy. The compound 7d at 350 mg/kg exerted maximum glucose lowering effects whereas 7c showed minimum glucose lowering effects. All the compounds were effective, and experimental results were statistically significant at p<0.01 and p<0.05 level.Conclusion: From the results, it is clear that compound 7d demonstrated potent anti-diabetic activity and would be of better use in drug development to combat the metabolic disorder in future

Exploring Herbal Remedies for Anti-Leishmanial Activity: A Comprehensive Review

- Leishmaniasis remains a serious neglected illness worldwide, posing significant challenges in its treatment due to the side effects of existing medications and the rising cases of parasite resistance resulting from indiscriminate treatment. To address this issue, exploring complementary remedies using natural products presents a promising option by combining the empirical knowledge of local populations with scientific research on the medicinal properties of plants. Several studies have investigated herbal treatments for leishmaniasis; however, more research is needed to identify safe and non-toxic remedies. To consolidate the latest findings, researchers from around the globe have compiled a comprehensive article on herbal and organic medicines used to treat leishmaniasis. While many medicinal plants have not been extensively studied, promising candidates have undergone prospective clinical trials. Recent articles have explored the active constituents of these medicinal plants, such as quinones, phenolic compounds, lignans, tannins, terpenes, and oxylipins, shedding light on their potential therapeutic benefits. Pharmacognosy views medicinal plants as valuable sources for developing novel medications and supporting traditional therapies, offering a practical approach to managing various illnesses. In summary, harnessing the power of natural goods and integrating traditional knowledge with scientific research provides a viable and desirable strategy to combat leishmaniasis, promoting safer and more effective treatment options in the future

In-silico molecular docking for Potential herbal leads from Withaniasomnifera L. Dunal for the treatment of Alzheimer’s disease

Alzheimer's disease (AD) poses a significant global health challenge, necessitating novel therapeutic interventions. Withaniasomnifera L. Dunal, commonly known as Ashwagandha, has been historically utilized in traditional medicine for its neuroprotective properties. This study employs computational techniques to explore the potential of W. somnifera compounds in targeting key proteins associated with AD. The reported phytoconstituents of W. somnifera were identified and subjected to molecular docking studies against 5NUU (Torpedo californica acetylcholinesterase in complex with a chlorotacrine-tryptophan hybrid inhibitor), as crucial targets. The results revealed several phytoconstituents of W. somnifera exhibiting favorable binding affinities and promising interactions with the target proteins. These findings provide a valuable foundation for further experimental validation and the development of novel therapeutic agents derived from natural sources for the treatment of Alzheimer's

Molecular Docking studies of chemical constituents of Rauwolfia serpentina on hypertension

Hypertension is still a prevalent cardiovascular disorder which remains a major global health concern. Rauwolfia serpentina, renowned for its therapeutic potential in managing hypertension, harbors a diverse array of bioactive compounds. This study aimed to elucidate the molecular interactions of chemical constituents derived from Rauwolfia serpentina with key hypertensive targets through molecular docking simulations. Utilizing computational tool, a comprehensive library of phytoconstituents obtained from Rauwolfia serpentina was constructed and subjected to molecular docking analyses against human angiotensin receptor (4ZUD) as target protein. The results revealed significant binding affinities between the chemical constituents of Rauwolfia serpentina and the active sites of these molecular targets. This study bridges the knowledge gap regarding the molecular mechanisms underlying the antihypertensive effects of Rauwolfia serpentina's constituents through computational simulations. The identified compounds exhibiting strong binding affinities and favorable interactions serve as promising candidates for further in vitro and in vivo studies, offering avenues for the development of novel therapeutic agents for hypertension management

Current Opinion on Food Sustainability for Liver Associated Health Problems: Facts and Myths with Case Study

The liver is the second-largest organ in our body which separates the nutrients and waste as they move through our biological process system and it additionally produces bile, a substance that carries toxins out of your body and aids in digestion. There are several myths associated with liver spread amongst masses. It is a vital necessity to make society devoid of such myths and aware of the real scenario. This review aimed to summarize the different facts and myths associated with health problems of liver and highlight the importance of food sustainability approach with the help of some case studies. A comprehensive literature search was conducted using various databases between 2006 and 2022 that focused on the various facts and myths associated with liver related health issues. Myths create nothing but false notions and fear amongst people. Some case studies were summarized to clear all the conflict statements commonly related with liver diseases in the society. Myths like nothing other than water is considered a good beverage for the liver, but recent studies have proven that measured quantities of coffee and herbal tea intake is healthy for the body. Additionally, coffee has a protective effect on the organ liver. Similarly, hepatitis can spread through casual contacts. Although it is proven that hepatitis B, C and autoimmune hepatitis, do not spread on having casual contact or sharing food and drink. A substantial myth states that blood tests can detect problems associated with the liver, but doctors rarely suggest blood tests for liver functioning. This review is focused to resolve several myths associated with the liver which are often considered true by masses