922 research outputs found

    Maternal and neonatal outcome in cases of premature rupture of membranes beyond 34 weeks of gestation

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    Background: Preterm premature rupture of membrane (PPROM) and premature rupture of membrane (PROM) are associated with various maternal and neonatal complications. Management guidelines regarding rupture of membrane before labour is still controversial. The study was carried out to determine the various maternal and neonatal outcomes associated with rupture of membranes beyond 34 weeks of gestation.Methods: It was a prospective observational study carried out in a tertiary care teaching hospital for a period of one year. All the pregnant women with rupture of membrane beyond 34 weeks are included in the study. After establishment of diagnosis of rupture of membranes, antibiotics were started and all of them were induced after 6 hours if they did not have spontaneous labour. Various maternal and neonatal outcomes were noted and statistical analysis carried out.Results: Incidence of rupture of membrane in our study was 4.2%. 92% of patients delivered within 24 hours of rupture of membrane and 18% of them required caesarean section. 5 neonates had respiratory distress syndrome and 1 neonate had sepsis.Conclusions: Induction of labour and delivery within 24 hours of rupture of membranes associated with low incidence of maternal and neonatal adverse outcome

    Cervical ectopic pregnancy: a rare complication

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    Cervical ectopic gestation is a rare site and frequently confused with neoplastic process. Profuse bleeding can occur if the placenta is mistaken for a tumor and a biopsy is taken which may lead to hysterectomy. Cervical gestation also can be mistaken for an incomplete abortion where Products Of Conception (POC) are retained within the cervical canal may lead to diagnostic dilemma. We are presenting a case of cervical ectopic which was successfully managed conservatively

    Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology

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    The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A 32 full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X1) and stirring speed (X2), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release. The best batch exhibited a high entrapment efficiency of 70% and mean particle size 290 μm. The drug release was also sustained for more than 12 hours. The study helped in finding the optimum formulation with excellent sustained drug release

    A rare case of thyroid storm following caesarean section

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    Thyroid storm in pregnancy is a rare life threatening emergency, with very high maternal and perinatal mortality and morbidity. Here we present an unusual case of a 30 year-old G2P1L1 woman, a known case of post caesarean pregnancy with hyperthyroidism who presented with severe preeclampsia and on second post op day developed thyroid storm. Early recognition and timely institution of appropriate management resulted in good outcome in this case

    Formulation and evaluation of gliclazide loaded controlled release microspheres

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    The aim of this study was to formulate gliclazide loaded controlled release microspheres. Microspheres were prepared by quasi emulsion solvent diffusion technique using eudragit RLPO, eudragit RSPO and with their various combinations. The effect of different formulation variables (drug-polymer ratio and polymer-polymer ratio) on percent yield, mean particle size, encapsulation efficiency and in vitro release of drug were evaluated. In vivo test of the optimized formulation was performed on streptozotocin induced type-2 diabetic rat model. The formulated microspheres showed higher encapsulation efficiencies within the range of 72-84 %. Mean particle size, encapsulation efficiency and in vitro release were found to be affected by changing in formulation variables. In vitro release study revealed the gliclazide release from the microspheres was extended for more than 12 h. In vivo hypoglycemic effect of microspheres was more than 25 h suggesting microspheres are a valuable system for sustained delivery of gliclazide.Colegio de Farmacéuticos de la Provincia de Buenos Aire

    Formulation and evaluation of gliclazide loaded controlled release microspheres

    Get PDF
    The aim of this study was to formulate gliclazide loaded controlled release microspheres. Microspheres were prepared by quasi emulsion solvent diffusion technique using eudragit RLPO, eudragit RSPO and with their various combinations. The effect of different formulation variables (drug-polymer ratio and polymer-polymer ratio) on percent yield, mean particle size, encapsulation efficiency and in vitro release of drug were evaluated. In vivo test of the optimized formulation was performed on streptozotocin induced type-2 diabetic rat model. The formulated microspheres showed higher encapsulation efficiencies within the range of 72-84 %. Mean particle size, encapsulation efficiency and in vitro release were found to be affected by changing in formulation variables. In vitro release study revealed the gliclazide release from the microspheres was extended for more than 12 h. In vivo hypoglycemic effect of microspheres was more than 25 h suggesting microspheres are a valuable system for sustained delivery of gliclazide.Colegio de Farmacéuticos de la Provincia de Buenos Aire
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