COMPARATIVE ANALYSIS OF THE TEMPORARY SERVICE CONTRACT IN THE LEGAL SYSTEMS OD THE REPUBLIC OF SERBIA, NORTHERN MACEDONIA AND EUROPEAN COUNTRIES

The need for research and analysis of temporary service contracts is self-evident, giventhe fact that this contract in modern law has significantly expanded its scope of application,especially to various intellectual, cultural, scientific and other agency work, with several newrules in the field and rights and obligations of the contracting parties. Nevertheless, the basicideas, the legal cornerstone of the temporary service contract, such as the concept, consensualcharacter and basic rights and obligations still remain the same in modern law, but with theaddition of legal solutions on other components in accordance with the needs of modern lifeand labor market, which will be explained further in the paper

Lipoprotein-Associated Phospholipase A2 – Pathophysiological Role and Clinical Significance as a Cardiovascular Biomarker

Within the last decade, a broad range of biomarkers associated with an increased risk for death and cardiovascular/cerebrovascular endpoints have been identified. Epidemiological studies clearly indicate that lipoprotein-associated phospholipase A2 (Lp-PLA2) has the potential to become clinically useful emerging biomarker in the true sense, linking plaque biology with cardiovascular/cerebrovascular event rate. Lipoprotein-associated phospholipase A2 is a specific vascular inflammatory marker, a risk factor, a prognostic biomarker, and also a therapeutic target. This chapter will summarize our current knowledge on Lp-PLA2 with emphasis on its potential pathophysiological mechanisms of action and on clinical relevance as cardiovascular/cerebrovascular biomarker. This chapter gives comprehensive, systematic review of studies assessing the significance of Lp-PLA2 in cardiovascular/cerebrovascular diseases with emphasis on clinical benefit of pharmacologic inhibition of Lp-PLA2

Presepsin as a Diagnostic and Prognostic Biomarker in Sepsis

Sepsis is defined as a life-threatening condition with organ failure, caused by an inadequate response of the host to the infection. It is a public health and economic problem worldwide. Early and accurate diagnosis of sepsis and timely inclusion of appropriate therapy are important for the outcome of the treatment of patients with sepsis. Sepsis biomarkers may provide information to achieve an early diagnosis, and predict prognosis and therapeutic response. Today, the literature lists more than 250 different biomarkers related to sepsis. However, stronger clinical evidence of clinical usefulness has emerged only for a few biomarkers from many published studies and meta-analyses. Among them, presepsin (sCD14-ST) appears to be one of the most promising biomarkers of sepsis in daily clinical practice. This chapter highlights the utility of presepsin as a diagnostic and prognostic biomarker of sepsis both in adult and pediatric patients

ARRANGEMENT OF OUTDOOR SPACE AT PRESCHOOL INSTITUTIONS IN THE CITY OF NIS

Open spaces within the preschools should be thoroughly planned during the design of the facilities. To children who use the services of a preschools, these spaces make their stay interesting, and for that reason facilities in courtyards and green spaces should be carefully planned. These parameters of urbanism were taken into account when we looked at open spaces in preschools on the territory of Nis. This work includes analyses of all 20 preschools in the city of Nis, with the aim to draw attention to the situation in the region and the problems they face

Biomarkers in Idiopathic Pulmonary Fibrosis

Numerous published papers are investigating the utility of biomarkers in Idiopathic Pulmonary Fibrosis (IPF) diagnosis, treatment, and outcome prediction. This chapter will summarize our current knowledge about biomarkers associated with alveolar epithelial cell damage and dysfunction (Krebs von den Lungen, surfactant proteins, the mucin MUC5B, CA 15-3, CA 125, CA 19-9, defensins, Clara cell protein (CC16), telomere shortening), biomarkers associated with fibrogenesis, fibroproliferation and extracellular matrix (ECM) remodeling (MMPs and their inhibitors, osteopontin, periostin, insulin-like growth factors, fibulin-1, heat shock protein 47, lysyl oxidase-like 2, circulating fibroblasts, extracellular matrix neoepitopes) and biomarkers related to immune dysfunction and inflammation (C-C chemokine ligand-18, C-C chemokine 2, YKL-40, C-X-C motif chemokine 13, S100A4, S100A8/9, S100A12, autoantibodies to heat shock protein 72, toll-like receptor 3, soluble receptor for advanced glycosylated end products, endothelial damage (vascular endothelial growth factor, interleukin 8, endothelin 1). The future directions in incorporating IPF biomarkers into clinical practice will be reviewed

Artificial intelligence and thyroid disease management: considerations for thyroid function tests

Artificial intelligence (AI) is transforming healthcare and offers new tools in clinical research, personalized medicine, and medical diagnostics. Thyroid function tests represent an important asset for physicians in the diagnosis and monitoring of pathologies. Artificial intelligence tools can clearly assist physicians and specialists in laboratory medicine to optimize test prescription, tests interpretation, decision making, process optimization, and assay design. Our article is reviewing several of these aspects. As thyroid AI models rely on large data sets, which often requires distributed learning from multi-center contributions, this article also briefly discusses this issue

Genotoksični efekat metanolskog ekstrakta biljke Cotinus Coggygria Scop. kod Drosophila Melanogaster

Plant extracts that appear to have favorable properties, may contain chemical compounds with mutagenic, teratogenic and/or carcinogenic activity, and it is of great importance to the inclusion of genotoxic approaches to toxicological evaluation of plant extracts. Using a comet assay on eukaryotic model organism Drosophila melanogaster in in vivo condition, potential genotoxic activity of the methanol extract of plant Cotinus coggygria Scop. was determined. Treatment with the methanol extracts, at a concentration of 1%, caused no significant changes compared to the negative control. Based on the distribution of comet class and selected quantitative parameters (% DNA in tail and tail length) it can be concluded that a methanol extract obtained from C. coggygria at a concentration of 1% does not shows genotoxic activity.Uključivanje genotoksičnog pristupa u toksikološku evaluaciju biljnih ekstrakata, koji i pored povoljnih svojstava mogu da sadrže komponente sa mutagenim, teratogenim i/ili kancerogenim aktivnostima, je od velike važnosti. Primenom Komet testa kod eukariotskog model organizma Drosophila melanogaster u in vivo uslovima ispitivana je genotoksična aktivnost metanolskog ekstrakta biljke Cotinus coggygria Scop. Тretman sa ekstraktom u koncentraciji od 1% nije uzrokovao statistički značajne promene u odnosu na negativnu kontrolu. Na osnovu raspodela komet klasa i odabranih kvantitativnih parametara može se zaključiti da ekstrakt biljke C. coggygria ne pokazuje genotoksičnu aktivnost