An Intelligent Disease Prediction and Drug Recommendation Prototype by Using Multiple Approaches of Machine Learning Algorithms

Large blocks of data must be analyzed and explored by utilizing the data mining procedures in order to uncover significant patterns and trends. Medical databases are one area where the data mining procedures can be utilized. Many people all over the world are struggling with their health and medical diagnoses. Massive amounts of data are produced by hospital information systems (HIS), yet it might be difficult to extract knowledge from diagnosis case data. By just giving the symptoms they are experiencing, patients can quickly learn about the sickness they are experiencing and the medication that can assist, treat it using the approaches utilized in this paper. In this paper, we give drug recommendations relied on ratings and conditions to customers. Four distinct prototypes are utilized to predict the diseases. The Vader tool and sentiment analysis relied on NLP are utilized to analyze the reviews. And finally, probabilistic and weighted average methodologies are utilized to recommend the medications. Each model and strategy utilized in this paper is described in detail. The experimental findings presented in this work can be utilized in future studies and for a variety of different medicinal applications

Unusual association of Meckel's diverticulum with double appendix – A rare finding

INTRODUCTION: Appendix duplication is an extremely rare congenital anomaly that is seen in 0.004–0.009% of appendectomy specimens. Duplicated appendix may be associated with number of congenital anomalies. PRESENTATION OF CASE: In this case report, we are presenting a rare case of duplicated vermiform appendix with a co-existing Meckel's diverticulum. DISCUSSION: Anomalies of appendix are rare and duplication of vermiform appendix is extremely rare. In 1936, Cave classified appendiceal duplication for the first time which was modified by Wallbridge in 1963 into three types. Concomitant malformations or duplications of the large intestine or the genitourinary system may be present, especially in types B1 and C probably due to their similar embryological origin. Here we are presenting a very rare case report of type B1 appendix anomaly associated with Meckel's diverticulum. CONCLUSION: Surgeons should be aware of these conditions because of the possible clinical implications

“An unusual presentation of colonic mucormycosis mimicking carcinoma colon- a surgeon’s perspective”

Introduction: Mucormycosis caused by order mucorales, an ubiquitous saprophytic mold found in soil and organic matter worldwide, is a rare but invasive opportunistic fungal infection. Gastrointestinal mucormycosis is the most uncommon clinical presentation being particularly rare, accounted for 4–7% of all cases. Presentation of case: We report an unusual presentation of mucormycosis of ascending colon that was simulating carcinoma colon. Discussion: GI mucormycosis most commonly involves the stomach (57.5%), followed by the colon (32.3%) and the ileum (6.9%). Initial presentations may be abdominal pain and distension, fever, and diarrhoea. Colonic mucormycosis presenting as a mass with altered bowel habit, melena and abdominal pain in our case is extremely difficult to differentiate it from carcinoma colon. A definitive diagnosis of mucormycosis is almost always ascertained by histopathological evidence of fungal invasion of tissue. Conclusion: Knowing these unusual presentations of this disease, surgeon need to maintain a high index of suspicion and perform timely and appropriate diagnostic evaluation to improve patient outcome. Prompt diagnosis, reversal of predisposing conditions, and aggressive surgical debridement remain cornerstones of therapy for this deadly disease

GROSS MORPHOLOGY AND ENCEPHALIZATION QUOTIENT OF BRAIN IN MALE AND FEMALE VANARAJA CHICKENS AT DIFFERENT AGES

One hundred fifty day-old sexed Vanaraja chicks (75 male + 75 female) were taken as experimental birds. Dissection of cranium was performed carefully and study of gross morphology of brain was undertaken at different ages in male and female birds. The brain in situ appeared like a ‘spade’ symbol in playing card but it appeared rather wider and globular in both sexes. The cerebrum varied from pear to oval or even globular in shape in both sexes. On dorsal view, the cerebral hemispheres appeared moderately convex and smooth surfaced. On ventral surface, ill-developed olfactory lobes were observed anteriorly on either side of the median fissure in both male and female Vanaraja birds. The hippocampus was located transversely to the posterior one third parts of both cerebral hemispheres. Duncan’s EQ ranged from 5.801 ± 0.514 (T3-Male) to 5.944 ± 0.451 (T1-Female) on 21st day. There was significant decrease (p<0.05) in EQ from Day 21 to 42 across all the groups. On 84th day, the range of EQ was 1.346 ± 0.115 (T3-Male) to 1.444 ± 0.114 (T1-Female). In case of Cuvier’s EQ, on 21st day the value ranged from 35.079 ± 0.288 (T2-Male) to 36.531 ± 0.312 (T3-Female). There was significant reduction (p<0.05) in Cuvier’s EQ value from Trial-I (21st day) to Trial-II (42nd day). Again, a significant decrease in EQ value was evident from Trial-III (63rd Day) to Trial-IV (84th Day). On 84th day, the EQ ranged from 15.607 ± 0.123 (T3-Male) to 16.038c ± 0.125 (T2-Male). Duncan’s formula had very high correlation coefficient with brain length (0.915). There was also very high degree correlation between brain weight and body weight (0.963). Brain weight and neuronal size are also highly correlated (0.902). Neuronal size and brain volume are also having a high correlation (0.902). The EQ values had medium correlation with neuronal size (0.701 for Cuvier’s Formula and 0.713 for Duncan’s formula). Duncan’s and Cuvier’s value had a very high degree of correlation (0.998)