Mefenacet [2-(1,3-benzothia­zol-2-yl­oxy)-N-methyl-N-phenyl­acetamide]

The title compound, C16H14N2O2S, crystallizes with two independent mol­ecules in the asymmetric unit. The dihedral angles between the plane of the benzothia­zole ring system and the phenyl ring plane are 51.63 (7) and 60.46 (5)°. In the crystal structure, weak inter­molecular C—H⋯O hydrogen bonds and C—H⋯π inter­actions contribute to the stabilization of the packing

Monocrotophos: dimethyl (E)-1-methyl-2-(methyl­carbamo­yl)ethenyl phosphate

In the title compound, C7H14NO5P, the phosphate group displays rotational disorder of three O atoms with an occupancy ratio of 0.832 (6):0.167 (6). The dihedral angle between the acryl­amide group and PO2 plane of the phosphate group is 75.69 (7)°. In the crystal, inter­molecular N—H⋯O and C—H⋯O hydrogen bonds link the molecules

Phosmet: O,O-dimethyl S-phthalimidomethyl phospho­rodithio­ate

In the title compound, C11H12NO4PS2, the dihedral angle between the phthalimidyl ring plane and the PS2 plane of the phospho­rodithio­ate group is 60.41 (3)°. In the crystal structure, weak inter­molecular C—H⋯O hydrogen bonds and S⋯S inter­actions [3.3825 (9) Å] contribute to the stabilization of the packing

Rhus verniciflua Stokes against Advanced Cancer: A Perspective from the Korean Integrative Cancer Center

Active anticancer molecules have been searched from natural products; many drugs were developed from either natural products or their derivatives following the conventional pharmaceutical paradigm of drug discovery. However, the advances in the knowledge of cancer biology have led to personalized medicine using molecular-targeted agents which create new paradigm. Clinical benefit is dependent on individual biomarker and overall survival is prolonged through cytostatic rather than cytotoxic effects to cancer cell. Therefore, a different approach is needed from the single lead compound screening model based on cytotoxicity. In our experience, the Rhus verniciflua stoke (RVS) extract traditionally used for cancer treatment is beneficial to some advanced cancer patients though it is herbal extract not single compound, and low cytotoxic in vitro. The standardized RVS extract's action mechanisms as well as clinical outcomes are reviewed here. We hope that these preliminary results would stimulate different investigation in natural products from conventional chemicals

Imazalil: 1-[2-(2,4-dichlorophenyl)-2-(prop-2-enyloxy)ethyl]-1H-imidazole

In the title compound, C14H14Cl2N2O, the imidazole ring is almost parallel to the benzene ring, the dihedral angle between them being 7.3 (2)°. In the crystal, there is an intermolecular C—Cl...π interaction (Cl...centroid = 3.36 Å and C—Cl...centroid = 89.2°). In addition, a Cl...Cl contact of 3.411 (1) Å and an intermolecular C—H...N hydrogen bond are observed. These interactions contribute to the stabilization of the crystal packing

Comparative study on atomic layer deposition of HfO(2)via substitution of ligand structure with cyclopentadiene

With the scaling down of complementary metal-oxide semiconductors (CMOS), atomic layer deposition of high-quality HfO2 has emerged as a key technology for ultrathin and high-k gate dielectrics. Recently, heteroleptic ligand structures have been introduced to complement the limitations of existing homoleptic precursors. Among the heteroleptic precursors, partial substitution with cyclopentadiene (Cp)-based ligands has been employed for controlling the volatility and thermal stability of precursors. In this study, we investigated the effects of the Cp ligand on the high-k properties of ALD HfO2 by comparing Hf(N(CH3)(2))(4) and CpHf(N(CH3)(2))(3) through theoretical and experimental methods. We theoretically predicted the changes in precursor behavior on the surface due to the Cp ligand, such as the high activation energy for the final chemisorption and the steric hindrance caused by the bulky Cp ligand. Additionally, we experimentally found that these changes affect not only the growth rate of ALD HfO2 but also the film properties. The Cp ligand on the surface sterically hinders the reaction of the nearby OH group with precursor molecules, retaining the residual OH content in the films. Consequently, the high OH content in the films degrades the film density and leakage current of ALD HfO2 as a high-k film

Controlled Reversible Crystal Transformation of Cu(I) Supramolecular Isomers

Four copper­(I) coordination polymers (CPs), {[CuI<b>L</b>]·CH₃CN]}_<i>n</i> (<b>1</b>), {[CuI<b>L</b>]·CHCl₃}_<i>n</i> (<b>2</b>), {[CuI<b>L</b>]·CH₂Cl₂}_<i>n</i> (<b>3</b>), and [CuI<b>L</b>]_<i>n</i> (<b>4</b>), were prepared by self-assembly reactions between CuI and (2-pyrazinylcarbonyl)­thiomorpholine (<b>L</b>). CPs <b>1</b>–<b>4</b> are interconnected by rhomboid Cu–I₂–Cu units. CPs <b>1</b> and <b>4</b> have one-dimensional loop-chain structures, and <b>2</b> and <b>3</b> adopt two-dimensional network structures. CPs <b>1</b>–<b>4</b> are pseudopolymorphic supramolecular isomers. CPs <b>2</b>′ and <b>3</b>′ are prepared by removal of solvate molecules from CPs <b>2</b> and <b>3</b>, which are polymorphic supramolecular isomers with CP <b>4</b>. Reversible crystal-to-crystal transformations were observed under appropriate conditions such as solvent or heat