Quantitative Understanding of Probabilistic Behavior of Living Cells Operated by Vibrant Intracellular Networks

For quantitative understanding of probabilistic behaviors of living cells, it is essential to construct a correct mathematical description of intracellular networks interacting with complex cell environments, which has been a formidable task. Here, we present a novel model and stochastic kinetics for an intracellular network interacting with hidden cell environments, employing a complete description of cell state dynamics and its coupling to the system network. Our analysis reveals that various environmental effects on the product number fluctuation of intracellular reaction networks can be collectively characterized by Laplace transform of the time-correlation function of the product creation rate fluctuation with the Laplace variable being the product decay rate. On the basis of the latter result, we propose an efficient method for quantitative analysis of the chemical fluctuation produced by intracellular networks coupled to hidden cell environments. By applying the present approach to the gene expression network, we obtain simple analytic results for the gene expression variability and the environment-induced correlations between the expression levels of mutually noninteracting genes. The theoretical results compose a unified framework for quantitative understanding of various gene expression statistics observed across a number of different systems with a small number of adjustable parameters with clear physical meanings.National Research Foundation of Korea (Grant 2011-0016412)National Research Foundation of Korea (Priority Research Center Program 2009-0093817

A Roadmap for Improving the Impact of Anti-Ransomware Research

Ransomware is a type of malware which restricts access to a victim’s computing resources and demands a ransom in order to restore access. This is a continually growing and costly threat across the globe, therefore efforts have been made both in academia and industry to develop techniques that can help to detect and recover from ransomware attacks. This paper aims to provide an overview of the current landscape of Windows-based anti-ransomware tools and techniques, using a clear, simple and consistent terminology in terms of Data Sources, Processing and Actions. We extensively analysed relevant literature so that, to the best of our knowledge, we had at the time covered all approaches taken to detect and recover from ransomware attacks. We grouped these techniques according to their main features as a way to understand the landscape. We then selected 15 existing anti-ransomware tools both to examine how they fit into this landscape and to compare them by aggregating their accuracy and overhead – two of the most important selection criteria of these tools – as reported by the tools’ respective authors. We were able to determine popular solutions and unexplored gaps that could lead to promising areas of anti-ransomware development. From there, we propose two novel detection techniques, namely serial byte correlation and edit distance. This paper serves as a much needed roadmap of knowledge and ideas to systematise the current landscape of anti-ransomware tools

The Effective Ransomware Prevention Technique Using Process Monitoring on Android Platform

Due to recent indiscriminate attacks of ransomware, damage cases including encryption of users’ important files are constantly increasing. The existing vaccine systems are vulnerable to attacks of new pattern ransomware because they can only detect the ransomware of existing patterns. More effective technique is required to prevent modified ransomware. In this paper, an effective method is proposed to prevent the attacks of modified ransomware on Android platform. The proposed technique specifies and intensively monitors processes and specific file directories using statistical methods based on Processor usage, Memory usage, and I/O rates so that the process with abnormal behaviors can be detected. If the process running a suspicious ransomware is detected, the proposed system will stop the process and take steps to confirm the deletion of programs associated with the process from users. The information of suspected and exceptional processes confirmed by users is stored in a database. The proposed technique can detect ransomware even if you do not save its patterns. Its speed of detection is very fast because it can be implemented in Android source code instead of mobile application. In addition, it can effectively determine modified patterns of ransomware and provide protection with minimum damage

Frequency spectrum of chemical fluctuation: A probe of reaction mechanism and dynamics.

Even in the steady-state, the number of biomolecules in living cells fluctuates dynamically, and the frequency spectrum of this chemical fluctuation carries valuable information about the dynamics of the reactions creating these biomolecules. Recent advances in single-cell techniques enable direct monitoring of the time-traces of the protein number in each cell; however, it is not yet clear how the stochastic dynamics of these time-traces is related to the reaction mechanism and dynamics. Here, we derive a rigorous relation between the frequency-spectrum of the product number fluctuation and the reaction mechanism and dynamics, starting from a generalized master equation. This relation enables us to analyze the time-traces of the protein number and extract information about dynamics of mRNA number and transcriptional regulation, which cannot be directly observed by current experimental techniques. We demonstrate our frequency spectrum analysis of protein number fluctuation, using the gene network model of luciferase expression under the control of the Bmal 1a promoter in mouse fibroblast cells. We also discuss how the dynamic heterogeneity of transcription and translation rates affects the frequency-spectra of the mRNA and protein number

Interaction between polymer-grafted nanoparticles in chemically identical homopolymer matrix

In this research, we develop a new numerical scheme of self-consistent field theory (SCFT) to quantify interparticle interaction between two spherical nanoparticles (NPs) coated with polymer grafts in chemically identical homopolymer melts. In our numerical SCFT calculation, twodimensional finite volume method (FVM) which efficiently conserves the amount of material in curvilinear coordinate is adopted, and the differential equation for partition function is solved in real space with Multicoordinate-system (MCS) scheme which makes use of the mirror symmetry between the two particles. In this research, we investigate how distribution of chain lengths, grafting density and particle curvature interplay roles on stabilization mechanism for dispersion by calculating interaction potentials between two polymer-coated NPs as functions of distance between the two particles. Our results reveal that polydisperse distribution stabilizes dispersions more efficiently than monodisperse counterparts