Patient characteristics.

<p>Abbreviations: HR, hormone receptor; IQR, interquartile range; HOMA-IR, homeostasis model assessment for insulin resistance; BMI, body mass index; CTx, chemotherapy; HRT, hormone therapy.</p

Adjusted hazard ratios of PGRN quartile levels for breast cancer recurrence.

<p>Adjusted for age, BMI, tumor size (<2 cm or ≥2 cm), lymph node metastasis (*HR-positive group only), adjuvant chemotherapy (yes or no), adiponectin, HOMA-IR and estradiol.</p><p>Abbreviations: HR, hormone receptor; LN, lymph node; Q, quartile.</p

Clinical Characteristics of Study Subjects according to Smoking Status.

<p>Data are presented as means ± SD.</p>*<p>P value <0.05,</p>†<p>P value<0.001.</p

Adjusted Odds Ratio of Visceral Obesity and Others according to the Smoking Amounts during a Lifetime.

<p>BMI = Body Mass Index, BF% = Body Fat Percentage, WC = Waist Circumference.</p

Comparing Mean Values of Anthropometric Measures with Smoking Amounts during a Lifetime.

<p>BMI = Body Mass Index, BF% = Body Fat Percentage, WC = Waist circumference, SCF = Abdominal Subcutaneous Fat.</p><p>Means in the same row with different superscript letters are significantly different, P<0.05 (ANOVA with Duncan’s post hoc test).</p

Adjusted Odds Ratio of Visceral Obesity and Others in Current and Past smokers.

<p>BMI = Body Mass Index, BF% = Body Fat Percentage, WC = Waist Circumference.</p

Age-adjusted fasting plasma clusterin concentrations in lean, overweight, and obese subjects.

<p>Data are mean ± SE.</p><p>*<i>P</i><0.05 <i>vs</i>. lean,</p>†<p><i>P</i><0.05 <i>vs</i>. overweight.</p

Clinical, anthropometric and biochemical characteristics of the study subjects.

<p>Data are the mean ± SD.</p>‡<p>Data are median values and range.</p>§<p>Logarithmic transformation was performed before the analysis.</p><p>*<i>P</i><0.01,</p>†<p><i>P</i><0.05 <i>vs.</i> lean. BMI, body mass index; WC, waist circumference; WHR, waist-hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure;: FPG, fasting plasma glucose; FPI, fasting plasma insulin; HOMA-IR homeostasis model of insulin resistance; TC, fasting plasma total cholesterol; TG, fasting plasma triglyceride; HDL-C, high density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; RBP4, retinol binding protein-4.</p

Correlation between fasting plasma clusterin concentrations and anthropometric and clinical parameters.

<p>γ: Pearson's coefficient.</p>§<p>Logarithmic transformation was performed before analysis. BMI, body mass index; WC, waist circumference; WHR, waist-hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; FPI, fasting plasma insulin; HOMA-IR homeostasis model of insulin resistance; TC, fasting plasma total cholesterol; TG, fasting plasma triglyceride; HDL-C, high density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; RBP4, retinol binding protein-4.</p

Independent variables affecting plasma clusterin concentration in stepwise multivariate analysis.

<p><i>R</i>²(coefficient of determination) for the model: 0.245. Multiple linear regression analysis was performed in 204 subjects. Data for HOMA-IR, TG/HDL-C, hsCRP, leptin, adiponectin, and RBP4 were log-transformed due to skewed distributions. In stepwise regression analysis, the independent variables tested initially were age, sex, smoking status, BMI, WHR, DBP, FPG, FPI, HOMA-IR, TC/HDL-C, TG/HDL-C, hsCRP, uric acid, ferritin, leptin, adiponectin, and RBP4 (abbreviations in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103351#pone-0103351-t001" target="_blank">Table 1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103351#pone-0103351-t003" target="_blank">3</a>). No combination with a strong correlation (<i>R</i>>0.9) was found among these variables after excluding HOMA-IR. Multiple regression analysis was performed among the remaining independent variables.</p>§<p>Logarithmic transformation was performed before analysis.</p