The order of the Roberge-Weiss endpoint (finite size transition) in QCD

We consider the endpoint of the Roberge-Weiss (RW) first order transition line present for imaginary baryon chemical potentials. We remark that it coincides with the finite size transition relevant in the context of large $N_c$ QCD and study its order in the theory with two degenerate flavors. The RW endpoint is first order in the limit of large and small quark masses, while it weakens for intermediate masses where it is likely in the Ising 3d universality class. Phenomenological implications and further speculations about the QCD phase diagram are discussed.Comment: 5 pages, 8 figures. Version accepted for publication in Physical Review D (R

Phase diagram of QCD with two degenerate staggered quarks

We present preliminary results about the critical line of QCD with two degenerate staggered quarks at nonzero temperature and chemical potential, obtained by the method of analytic continuation. As in our previous studies with different numbers of colors and flavors, we find deviations from a simple quadratic dependence on the chemical potential. We comment on the shape of the critical line at real chemical potential and give an estimate of the curvature of the critical line, both for quark chemical potential and isospin chemical potential.Comment: 7 pages, 6 figures, talk presented at Lattice 2011, The XXIX International Symposium on Lattice Field Theory, Squaw Valley, Lake Tahoe, California, USA, July 11-16, 201

The critical line of two-flavor QCD at finite isospin or baryon densities from imaginary chemical potentials

We determine the (pseudo)critical lines of QCD with two degenerate staggered fermions at nonzero temperature and quark or isospin density, in the region of imaginary chemical potentials; analytic continuation is then used to prolongate to the region of real chemical potentials. We obtain an accurate determination of the curvatures at zero chemical potential, quantifying the deviation between the case of finite quark and of finite isospin chemical potential. Deviations from a quadratic dependence of the pseudocritical lines on the chemical potential are clearly seen in both cases: we try different extrapolations and, for the case of nonzero isospin chemical potential, confront them with the results of direct Monte Carlo simulations. Finally we find that, as for the finite quark density case, an imaginary isospin chemical potential can strengthen the transition till turning it into strong first order.Comment: 11 pages, 11 figures, 4 table

An exploratory study of heavy domain wall fermions on the lattice

We report on an exploratory study of domain wall fermions (DWF) as a lattice regularisation for heavy quarks. Within the framework of quenched QCD with the tree-level improved Symanzik gauge action we identify the DWF parameters which minimise discretisation effects. We find the corresponding effective 4$d$ overlap operator to be exponentially local, independent of the quark mass. We determine a maximum bare heavy quark mass of $am_h\approx 0.4$, below which the approximate chiral symmetry and O(a)-improvement of DWF are sustained. This threshold appears to be largely independent of the lattice spacing. Based on these findings, we carried out a detailed scaling study for the heavy-strange meson dispersion relation and decay constant on four ensembles with lattice spacings in the range $2.0-5.7\,\mathrm{GeV}$. We observe very mild $a^2$ scaling towards the continuum limit. Our findings establish a sound basis for heavy DWF in dynamical simulations of lattice QCD with relevance to Standard Model phenomenology.Comment: 23 pages, 8 figure

Editorial: Formal Ontologies meet Industry

The Formal Ontologies meet Industry (FOMI) workshop series is a scientific initiative supported by the International Association for Ontology and its Applications (IAOA) aimed at bringing together academics and practitioners interested in ontologies for industry. FOMI addresses research and application topics concerning, e.g., the design of domain-specific ontologies, the development of ontology-based information systems, or the investigation of the theoretical underpinnings of formal ontology when tuned to engineering applications

Tracking the Equator Into the Paleogene (abstract of paper presented at AGU Fall Meeting, San Francisco, 8-12 Dec 2003)

Stratigraphy has been compiled for 63 tropical Pacific drill sites that sample lower Neogene and Paleogene sediments. These Sites derive from drilling on DSDP Leg 5 through ODP Leg 199. All Sites have been put on the biostratigraphic and paleomagnetic timescale refined by Leg 199 scientists. Sediment accumulation rates have been calculated for ten intervals ranging in age from 10 Ma to 56 Ma. A simple fixed hotspot model was used for Pacific lithospheric plate rotation in reconstructing the position of the selected sites for each of these ten intervals. The reconstruction of all intervals show the development of a tongue of relatively high accumulation rates associated with the oceanographic divergence at the geographic equator. The estimated position of the geographic equator based on these reconstructions lies consistently south of the position of the equator based on the rotation model used. However, the southward displacement is generally 2 degrees of latitude or less. We believe that this relatively small disagreement between the two estimates of equatorial position back to 56 Ma indicates: 1) Whatever hotspot movement that may have occurred in the interval between 40 and 56 Ma did not affect the motion of the Pacific plate; its motion after 40 Ma appears to have been approximately the same as before 40 Ma. 2) The estimated rate of true polar wander during the interval of 40 - 56 Ma must be very small (~0.125$\deg$/m.y.) and is probably not significant (i.e., well within the error of these reconstructions)

Developing a Community-led Music Intervention to Support Antenatal Mental Health in The Gambia

Stress, anxiety and depression in pregnancy affect not only the mother but can also have long-term adverse effects on her child. Mental health problems in the perinatal period are a particular challenge in low- and middle-income countries (LMICs) where they can be at least twice as frequent as in higher-income countries (HICs). It is thus of high priority to develop new low-cost, low-resource, non-stigmatising and culturally appropriate approaches to reduce symptoms of anxiety and depression in pregnancy. Using a mixed-methods approach, this thesis aims to investigate how a community-led music intervention can be developed and implemented within The Gambia to help reduce symptoms of antenatal common mental disorders (CMDs). The first study summarises findings from 14 focus group discussions with a variety of stakeholders (health workers, musicians and pregnant women). A pictorial representation presents the three main contributing factors to mental distress symptoms: economic, social, and spiritual. The next study finds that two existing self-report tools, the Edinburgh Postnatal Depression Scale (EPDS) and the Self-Reporting Questionnaire (SRQ-20), can be used in The Gambia to measure antenatal CMD symptoms. A different distribution of scores is found, with the SRQ-20, which has more somatic items, giving higher scores. Differences in factor structures of the EPDS in a Gambian versus UK context shows potential differences in the expression of CMD symptoms between the two cultures. The final study demonstrates that a community health intervention through musical engagement (CHIME) can be co-developed and is feasible to administer within a Gambian context. Results also suggest a beneficial effect of CHIME compared to standard care and a potential greater reduction in symptoms in participants with higher levels of CMD symptoms. This thesis is the first to highlight the potential of music interventions to support women’s perinatal mental health care in a LMIC context

American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis for patients with COVID-19: March 2022 update on the use of anticoagulation in critically ill patients

BACKGROUND: COVID-19-related critical illness is associated with an increased risk of venous thromboembolism (VTE). OBJECTIVE: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in decisions about the use of anticoagulation for patients with COVID-19. METHODS: ASH formed a multidisciplinary guideline panel, including 3 patient representatives, and applied strategies to minimize potential bias from conflicts of interest. The McMaster University Grading of Recommendations Assessment, Development and Evaluation (GRADE) Centre supported the guideline development process, including performing systematic evidence reviews (up to January 2022). The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The panel used the GRADE approach to assess evidence and make recommendations, which were subject to public comment. This is an update to guidelines published in February 2021 and May 2021 as part of the living phase of these guidelines. RESULTS: The panel made 1 additional recommendation: a conditional recommendation for the use of prophylactic-intensity over therapeutic-intensity anticoagulation for patients with COVID-19-related critical illness who do not have suspected or confirmed VTE. The panel emphasized the need for an individualized assessment of thrombotic and bleeding risk. CONCLUSIONS: This conditional recommendation was based on very low certainty in the evidence, underscoring the need for additional, high-quality, randomized controlled trials comparing different intensities of anticoagulation for patients with COVID-19-related critical illness

Rituximab induced pulmonary edema managed with extracorporeal life support

Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after rituximab infusion. Despite advanced ventilatory settings, she developed severe respiratory acidosis and remained hypoxemic with a significant vasopressor requirement. Since her pulmonary insult was likely transient, ECLS was considered. Due to combined cardiorespiratory failure, she received support with peripheral venoarterial ECLS. During her ECLS course, she received daily plasmapheresis and high dose steroids. Her pulmonary function recovered and she was decannulated after 8 days. She was discharged after 23 days without residual sequelae