3 research outputs found
Framework for Optimizing Selection of Interspecies Correlation Estimation Models to Address Species Diversity and Toxicity Gaps in an Aquatic Database
The
Chemical Aquatic Fate and Effects (CAFE) database is a tool
that facilitates assessments of accidental chemical releases into
aquatic environments. CAFE contains aquatic toxicity data used in
the development of species sensitivity distributions (SSDs) and the
estimation of hazard concentrations (HCs). For many chemicals, gaps
in species diversity and toxicity data limit the development of SSDs,
which may be filled with Interspecies Correlation Estimation (ICE)
models. Optimization of ICE model selection and integration ICE-predicted
values into CAFE required a multistep process that involved the use
of different types of data to assess their influence on SSDs and HC
estimates. Results from multiple analyses showed that SSDs supplemented
with ICE-predicted values generally produced HC5 estimates that were
within a 3-fold difference of estimates from measured SSDs (58%–82%
of comparisons), but that were often more conservative (63%–76%
of comparisons) and had lower uncertainty (90% of comparisons). ICE
SSDs did not substantially underpredict toxicity (<10% of comparisons)
when compared to estimates from measured SSD. The incorporation of
ICE-predicted values into CAFE allowed the development of >800
new
SSDs, increased diversity in SSDs by an average of 34 species, and
augmented data for priority chemicals involved in accidental chemical
releases
Acute Toxicity Prediction to Threatened and Endangered Species Using Interspecies Correlation Estimation (ICE) Models
Evaluating
contaminant sensitivity of threatened and endangered
(listed) species and protectiveness of chemical regulations often
depends on toxicity data for commonly tested surrogate species. The
U.S. EPA’s Internet application Web-ICE is a suite of Interspecies
Correlation Estimation (ICE) models that can extrapolate species sensitivity
to listed taxa using least-squares regressions of the sensitivity
of a surrogate species and a predicted taxon (species, genus, or family).
Web-ICE was expanded with new models that can predict toxicity to
over 250 listed species. A case study was used to assess protectiveness
of genus and family model estimates derived from either geometric
mean or minimum taxa toxicity values for listed species. Models developed
from the most sensitive value for each chemical were generally protective
of the most sensitive species within predicted taxa, including listed
species, and were more protective than geometric means models. ICE
model estimates were compared to HC5 values derived from Species Sensitivity
Distributions for the case study chemicals to assess protectiveness
of the two approaches. ICE models provide robust toxicity predictions
and can generate protective toxicity estimates for assessing contaminant
risk to listed species
SEPMdata
Data used to simulate sheepshead minnow exposure to oiled sediment in Barataria Bay, Louisiana following the Deepwater Horizon oil spill. Files include temperature- and concentration-specific population parameters, laboratory data used to derive oiled sediment effects on growth and survival, field data used in habitat suitability model, and temperature and oiling severity data from Barataria Bay