2 research outputs found
Ligandless Palladium-Catalyzed Regioselective Direct C–H Arylation of Imidazo[1,2‑<i>a</i>]imidazole Derivatives
Herein a novel access to functionalizable
6-substituted imidazo[1,2-<i>a</i>]imidazole scaffolds is
described. The reactivity of this
heterobicyclic unit toward direct C–H arylation was studied,
and conditions allowing regioselective arylation at position 3 were
successfully developed. The practicability of this method is manifested
by the ligandless conditions and low catalyst loading. The strategy
is functional group tolerant and provides rapid access to a large
variety of 3,6-di(hetero)arylated imidazo[1,2-<i>a</i>]imidazole
derivatives. A second arylation at position 2 was then carried out,
and a library of diversified 2,3,6-tri(hetero)arylated imidazo[1,2-<i>a</i>]imidazoles was generated in good yields. A one-pot, two-step
procedure was finally developed
Ligandless Palladium-Catalyzed Regioselective Direct C–H Arylation of Imidazo[1,2‑<i>a</i>]imidazole Derivatives
Herein a novel access to functionalizable
6-substituted imidazo[1,2-<i>a</i>]imidazole scaffolds is
described. The reactivity of this
heterobicyclic unit toward direct C–H arylation was studied,
and conditions allowing regioselective arylation at position 3 were
successfully developed. The practicability of this method is manifested
by the ligandless conditions and low catalyst loading. The strategy
is functional group tolerant and provides rapid access to a large
variety of 3,6-di(hetero)arylated imidazo[1,2-<i>a</i>]imidazole
derivatives. A second arylation at position 2 was then carried out,
and a library of diversified 2,3,6-tri(hetero)arylated imidazo[1,2-<i>a</i>]imidazoles was generated in good yields. A one-pot, two-step
procedure was finally developed