14 research outputs found
Contribution à l'étude de la translocation t(14 ; 18) dans les lymphomes folliculaires (intérêt des sondes clonospécifiques dans la direction de la maladie résiduelle)
TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF
Retrospective analysis of real-world data to evaluate actionability of a comprehensive molecular profiling panel in solid tumor tissue samples (REALM study).
IntroductionConsidering the growing interest in matched cancer treatment, our aim was to evaluate the ability of a comprehensive genomic profiling (CGP) assay to propose at least one targeted therapy given an identified genomic alteration or signature (actionability), and to collect the treatment modifications based on the CGP test results in clinical practise for solid tumors.MethodsThis retrospective, multicentre French study was conducted among 25 centres that participated in a free of charge program between 2017 and 2019 for a tissue CGP test. Data were collected on the patient, disease, tumor genomic profile, treatment suggested in the report (related to the genomic profile results) and subsequent therapeutic decisions according to the physician's declaration.ResultsAmong the 416 patients, most had lung cancer (35.6%), followed by biliary tract cancer (11.5%) or rare cancers (11.1%); 75% had a metastatic disease. The actionability was 75.0% (95% CI [70.6%-78.9%]) for all patients, 85.1% and 78.4%, respectively in lung cancer and metastatic patients. After exclusion of clinical trial suggestions, the actionability decreased to 62.3% (95% CI [57.5%-66.8%]). Treatment modification based on the test results was observed in 17.3% of the patients and was more frequent in metastatic disease (OR = 2.73, 95% CI [1.31-5.71], p = 0.007). The main reasons for no treatment modification were poor general condition (33.2%) and stable disease or remission (30.2%). The genomic-directed treatment changes were performed mostly during the first six months after the CGP test, and interestingly a substantial part was observed from six to 24 months after the genomic profiling.ConclusionThis French study provides information on the real-life actionability of a CGP test based on tissue samples, and trends to confirm its utility in clinical practice across the course of the disease, in particularly for patients with lung cancer and/or advanced disease
Clinical characteristics and F1CDx test results in metastatic patients.
Clinical characteristics and F1CDx test results in metastatic patients.</p
Cumulative incidence of test-informed (genomic-directed) treatment, from the time when F1CDx results were available (Kalbfleisch and Prentice curve).
Cumulative incidence of test-informed (genomic-directed) treatment, from the time when F1CDx results were available (Kalbfleisch and Prentice curve).</p
Clinical characteristics and F1CDx results in most frequent cancer types.
Clinical characteristics and F1CDx results in most frequent cancer types.</p
Results of the F1CDx test in the evaluable population.
Results of the F1CDx test in the evaluable population.</p
Solid tumor types at F1CDx request time in the evaluable population (N = 416).
Cancer histology details: Lung (148): non-small cell carcinoma (125 adenocarcinoma, 12 squamous, 4 large cell, 2 sarcomatoid, 1 neuroendocrine, 3 other) and 1 small cell carcinoma; Sarcoma (16): angiosarcoma (1), chordoma (1) conventional chondrosarcoma (1), clear cell sarcoma (1), fibrosarcoma (1), hemangiopericytoma (1), leiomyosarcoma (2), meningeal melanocytoma (2), mesenchymal chondrosarcoma (2) stromal sarcoma of the sex cords (1), sarcoma (3, no details); Thymus (8): thymoma (2), carcinoma (6); Other (in Rare group, 22): adenoid cystic tumor (1), adrenocortical cancer (1), aggressive digital papillary adenocarcinoma (1), appendiceal carcinoma (1), digestive neuro-endocrine carcinoma (1), clear cell carcinoma of the endometrium (1), esthesioneuroblastoma (1), intestinal-type adenocarcinoma of the ethmoide (1), germinal tumor (1), lymphoepithelial carcinoma of the larynx (1), epithelioid mesothelioma (2), pituitary carcinoma (1), pleural mesothelioma (1), malignant teratoma (1), paraganglioma (1), anal squamous cell carcinoma (2), ocular melanoma (1), ovarian clear cell carcinoma (2), undifferentiated neuroendocrine tumor of unknown primary (1).</p
Fig 3 -
Univariate analysis (A) and Multivariate analysis (B) to identify potential factor influencing test-informed (genomic-directed) treatment of F1CDx test. CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; TMB, tumor mutation burden.</p
Genomic directed treatments.
IntroductionConsidering the growing interest in matched cancer treatment, our aim was to evaluate the ability of a comprehensive genomic profiling (CGP) assay to propose at least one targeted therapy given an identified genomic alteration or signature (actionability), and to collect the treatment modifications based on the CGP test results in clinical practise for solid tumors.MethodsThis retrospective, multicentre French study was conducted among 25 centres that participated in a free of charge program between 2017 and 2019 for a tissue CGP test. Data were collected on the patient, disease, tumor genomic profile, treatment suggested in the report (related to the genomic profile results) and subsequent therapeutic decisions according to the physician’s declaration.ResultsAmong the 416 patients, most had lung cancer (35.6%), followed by biliary tract cancer (11.5%) or rare cancers (11.1%); 75% had a metastatic disease. The actionability was 75.0% (95% CI [70.6%-78.9%]) for all patients, 85.1% and 78.4%, respectively in lung cancer and metastatic patients. After exclusion of clinical trial suggestions, the actionability decreased to 62.3% (95% CI [57.5%-66.8%]). Treatment modification based on the test results was observed in 17.3% of the patients and was more frequent in metastatic disease (OR = 2.73, 95% CI [1.31–5.71], p = 0.007). The main reasons for no treatment modification were poor general condition (33.2%) and stable disease or remission (30.2%). The genomic-directed treatment changes were performed mostly during the first six months after the CGP test, and interestingly a substantial part was observed from six to 24 months after the genomic profiling.ConclusionThis French study provides information on the real-life actionability of a CGP test based on tissue samples, and trends to confirm its utility in clinical practice across the course of the disease, in particularly for patients with lung cancer and/or advanced disease.</div