5 research outputs found
Histogram of the posterior probabilities of having a positive (negative) SNP effect by Bayesian Threshold LASSO model (BTL) in the total population.
<p>The dot point line indicates the cut-off point of 80% above which SNPs were considered.</p
Risk estimates of Bayesian Threshold LASSO model (BTL), considering a posterior probability higher than 80%, and from logistic regression for the total population.
<p><sup>a</sup> Posterior mean of the OR, calculated from the BTL analyses Similar values for the median were obtained for each SNP.</p><p><sup>b</sup> It corresponds to , where .</p><p><sup>c</sup> OR obtained from the adjusted logistic regression.</p><p><sup>d</sup><i>p</i>-value of the trend obtained from the adjusted logistic regression.</p><p>SNPs also selected by AUC-RF are bold-faced.</p
Venn diagrams showing the overlapping between the SNPs selected by Bayesian Threshold model (BTL) and AUC-Random Forest (AUC-RF).
<p>(A) Number of SNPs detected by each method in the total population. (B) Number of SNPs detected by each method in the non-smoker subset. (C) Number of common SNPs detected by BTL in the total population and non-smoker subset, with posterior probabilities of at least 80% and 75% of having an effect different from 0. (D) Number of SNPs detected by AUC-RF in both the total population and the non-smoker subset.</p
Risk estimates from Bayesian Threshold LASSO model (BTL), considering a posterior probability of 75%, and from logistic regression analyses among non-smokers.
a<p>Posterior mean of the OR, calculated from the BTL analyses. Similar values for the median were obtained for each SNP.</p>b<p>It corresponds to , where .</p>c<p>OR obtained from the adjusted logistic regression.</p>d<p><i>p</i>-value of the trend obtained from the adjusted logistic regression.</p><p>SNPs also selected by AUC-RF are bold-faced.</p
Relative variable importance for the top 12 polymorphisms selected by AUC-RF in the total population.
a<p>Calculated by dividing the raw variable importance measurement by that with the highest MDG, that of smoking status.</p