186 research outputs found
A Rosetta Stone Relating Conventions In Photo-Meson Partial Wave Analyses
A new generation of complete experiments in pseudoscalar meson
photo-production is being pursued at several laboratories. While new data are
emerging, there is some confusion regarding definitions of asymmetries and the
conventions used in partial wave analyses (PWA). We present expressions for
constructing asymmetries as coordinate-system independent ratios of cross
sections, along with the names used for these ratios by different PWA groups.
(This update reflects a recent change in the definition of an asymmetry as used
by one group.)Comment: v2: This update reflects a recent change in the definition of an
asymmetry as used by one PWA group -see Table 1. v1: 4 pages. Contribution to
the proceedings of the 8th International Workshop on the Physics of Excited
Nucleons (NSTAR2011), Newport News, VA, USA, May 17-20, 201
Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts
Working with cultured dermal fibroblasts derived from control individuals and patients with systemic sclerosis (SSc), we have examined the effects of protein kinase C-delta (PKC-delta) on type I collagen biosynthesis and steady-state levels of COL1A1 and COL3A1 mRNAs. Rottlerin, a specific inhibitor of PKC-delta, exerted a powerful, dose-dependent inhibition of type I and type III collagen gene expression in normal and SSc cells. Optimal rottlerin concentrations caused a 70-90% inhibition of type I collagen production, a \u3e80% reduction in COL1A1 mRNA, and a \u3e70% reduction in COL3A1 mRNA in both cell types. In vitro nuclear transcription assays and transient transfections with COL1A1 promoter deletion constructs demonstrated that rottlerin profoundly reduced COL1A1 transcription and that this effect required a 129-bp promoter region encompassing nucleotides -804 to -675. This COL1A1 segment imparted rottlerin sensitivity to a heterologous promoter. Cotransfections of COL1A1 promoter constructs with a dominant-negative PKC-delta expression plasmid showed that suppression of this kinase silenced COL1A1 promoter activity. The results indicate that PKC-delta participates in the upregulation of collagen gene transcription in SSc and suggest that treatment with PKC-delta inhibitors could suppress fibrosis in this disease
Description of twelve cases of nephrogenic fibrosing dermopathy and review of the literature
ABSTRACT
Objectives: To review the clinical and laboratory features of twelve cases of nephrogenic fibrosing dermopathy (NFD) studied at our institution and of 70 previously described cases in the literature.
Methods: Clinical evaluation and laboratory studies of twelve patients with NFD associated with chronic hemodialysis or peritoneal dialysis for end-stage renal disease and a review of 23 previous publications describing 70 patients with this disease.
Results: Eleven patients undergoing chronic hemodialysis and one patient undergoing chronic peritoneal dialysis for end-stage renal failure developed a severe and progressive cutaneous fibrotic process with woody induration of legs, thighs, hands and forearms, and severe loss of motion and flexion contractures in multiple joints. Several patients displayed systemic involvement including fibrosis of muscles, myocardium and lungs and marked elevations of the erythrocyte sedimentation rate and/or C reactive protein. Three patients died within two years of onset of symptoms. A review of previously published reports of this disorder confirmed the presence of systemic involvement and a poor prognosis with a high rate of mortality.
Conclusions: The analysis of twelve cases and a review of 70 previously described cases indicate that NFD is a severe and usually progressive systemic fibrotic disease affecting the dermis, subcutaneous fascia and striated muscles. It also appears that the disease can cause fibrosis of lungs, myocardium and other organs
Measurements of polarized photo-pion production on longitudinally polarized HD and Implications for Convergence of the GDH Integral
We report new measurements of inclusive pion production from frozen-spin HD
for polarized photon beams covering the Delta(1232) resonance. These provide
data simultaneously on both H and D with nearly complete angular distributions
of the spin-difference cross sections entering the Gerasimov-Drell-Hearn (GDH)
sum rule. Recent results from Mainz and Bonn exceed the GDH prediction for the
proton by 22 microbarns, suggesting as yet unmeasured high-energy components.
Our pi0 data reveal a different angular dependence than assumed in Mainz
analyses and integrate to a value that is 18 microbarns lower, suggesting a
more rapid convergence. Our results for deuterium are somewhat lower than
published data, considerably more precise and generally lower than available
calculations.Comment: 4 pages, 4 figures. Submitted for publication in Physical Review
Letter
Spin observables for pion photoproduction on the deuteron in the (1232)-resonance region
Spin observables for the three charge states of the pion for the pion
photoproduction reaction on the deuteron, , with polarized
photon beam and/or oriented deuteron target are predicted. For the beam-target
double-spin asymmetries, it is found that only the longitudinal asymmetries
and do not vanish, whereas all the circular
and the other longitudinal asymmetries do vanish. The sensitivity of spin
observables to the model deuteron wave function is investigated. It has been
found that only and are sensitive to the model deuteron wave
function, in particular in the case of -production above the
-region, and that other asymmetries are not.Comment: 16 pages, 8 figures, accepted for publication in J. Phys. G: Nucl.
Part. Phy
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