Supplementary Figure 6 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 6 shows data from Ingenuity Pathway Analysis of colorectal cancer cells expressing NHE9, and the association between enrichment scores for Ca2+ signaling and NHE9 expression in colorectal cancer samples.</p

Supplementary Figure 3 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 3 shows the experimental protocol for measuring endosomal pH in colorectal cancer cells.</p

Supplementary Figure 9 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 9 shows data supporting the role of NHE9 on expression of MMP1 in colorectal cancer.</p

Supplementary Figure 5 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 5 shows NHE9 expression in primary and metastatic colorectal cancer patient samples.</p

Supplementary Figure 8 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 8 shows data supporting the role of NHE9 in cytosolic cAMP homeostasis in colorectal cancer.</p

Supplementary Figure 1 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 1 shows NHE9 immunohistochemistry in colorectal cancer and normal colon and rectal samples, and data analyzing gender differences in patient survival based on NHE9 expression.</p

Supplementary Figure 2 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 2 shows data on how NHE9 expression corresponds with EMT status in normal epithelial and mesenchymal populations of the intestine, and in human cancer cells.</p

Supplementary Figure 4 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplementary Figure 4 shows how NHE9 affects cell apoptosis and cell cycle progression in colorectal cancer cells.</p

Supplementary Table 1 from An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Supplemental Table 1 shows the parameter values for the mathematical model of endosomal pH.</p