An Experimental Investigation of Applying Mica2 Motes in Pavement Condition Monitoring

Pavement maintenance is vital for travel safety, thus detecting dangerous road conditions in a real-time fashion is desirable. Using an off-the-shelf wireless sensor network to detect such conditions at a low cost poses many challenges. In order to meet these challenges, a Mica2 Mote sensor network is adopted in this study to process and transmit data collected from three external analog sensors. Consequentially, several hardware and software interfaces are developed to complete a pavement monitoring system that uses temperature and moisture presence to detect hazardous road conditions. Surge Time Synchronization is explored in this specific application to enable the wireless sensor network to operate in a low power consumption mode. A fairly simplistic pattern classification algorithm is embedded into the motes to create the smart wireless sensing application. A series of outdoor tests are conducted in this study paying special attention to the survivability of fragile analog sensors in harsh roadway conditions. In this regard, a novel solution called the ``Sensor-Road Button''(SRB) is developed and validated experimentally. This is one of several exercises made in this study to enable the application of sensor technologies in intelligent transportation systems (ITS). The size of the wireless sensor network in this study is relatively small, utilizing a total of five motes in order to fully exploit the transmitting range of each mote. Long testing periods (i.e., uninterrupted 12-hour time frames for each period of data collection) add an additional advantage, allowing for the evaluation of the selected wireless sensor network for long-term monitoring using the low power consumption mode under Surge Time Synchronization. Many performance metrics of the adopted small-size, large-interval Mica2 Motes wireless sensor network are revealed in this study through a series of data processing efforts. Results are presented to examine (i) inter-node connectivity and transmitting range, (ii) battery life, (iii) the length of the initial network connection time as affected by methods of setting up tests under practical conditions, (iv) error rate and analysis of different error types (showing the importance of the subsequent data cleansing step), and (v) other network routing properties including the parent time histories for each mote. The results and analysis form a database for future efforts to better understand, appreciate, and improve the performance of Mica2 Motes. This study will thus benefit robust real-world implementation of off-the-shelf sensor network products such as Mica2 Motes in terms of hardware development and data processing.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Strategies and Practices in Off-Label Marketing of Pharmaceuticals: A Retrospective Analysis of Whistleblower Complaints

Aaron Kesselheim and colleagues analyzed unsealed whistleblower complaints against pharmaceutical companies filed in US federal fraud cases that contained allegations of off-label marketing, and develop a taxonomy of the various off-label practices

Dramatic Repositioning of c-Myb to Different Promoters during the Cell Cycle Observed by Combining Cell Sorting with Chromatin Immunoprecipitation

The c-Myb transcription factor is a critical regulator of proliferation and stem cell differentiation, and mutated alleles of c-Myb are oncogenic, but little is known about changes in c-Myb activity during the cell cycle. To map the association of c-Myb with specific target genes during the cell cycle, we developed a novel Fix-Sort-ChIP approach, in which asynchronously growing cells were fixed with formaldehyde, stained with Hoechst 33342 and separated into different cell cycle fractions by flow sorting, then processed for chromatin immunoprecipitation (ChIP) assays. We found that c-Myb actively repositions, binding to some genes only in specific cell cycle phases. In addition, the specificity of c-Myb is dramatically different in small subpopulations of cells, for example cells in the G2/M phase of the cell cycle, than in the bulk population. The repositioning of c-Myb during the cell cycle is not due to changes in its expression and also occurs with ectopically expressed, epitope-tagged versions of c-Myb. The repositioning occurs in established cell lines, in primary human CD34+ hematopoietic progenitors and in primary human acute myeloid leukemia cells. The combination of fixation, sorting and ChIP analysis sheds new light on the dynamic nature of gene regulation during the cell cycle and provides a new type of tool for the analysis of gene regulation in small subsets of cells, such as cells in a specific phase of the cell cycle

Wordi information processing : a system approach

xiii, 466 p.; 24 cm

Instrumentation and control of the AGS Booster vacuum system

The AGS Booster is a synchrotron for the acceleration of both protons and heavy ions. A pressure of low 10{sup {minus}11} Torr is required for the acceleration of the partially stripped, low {Beta}, very heavy ions. This paper describes the power supplies and controls for this ultra-high vacuum system with the emphasis on the operation of the ion gauge system over long cable length and on equipment interlock 4 refs., 2 figs., 1 tab