Chiral Lagrangian with higher resonances and flavour SU(3) SU(3) breaking

A chiral Lagrangian with $SU(3)$ breaking and higher resonances is proposed. In this model, the $SU(3)$ breaking structure in vector-pseudoscalar sector is realized with the decay constants of pseudoscalar mesons and the masses of vector mesons used as inputs. We examine whether the resulting $SU(3)$ breaking effect in the charge radii of pseudoscalar mesons is consistent with the experimental facts.Comment: 29 pages, REVTEX(ver.3), DPNU-93-3

Sociophysics Analysis of Multi-Group Conflicts

© 2020 by the authors. We present our research on the application of statistical physics techniques to multi-group social conflicts. We identify real conflict situations of which the characteristics correspond to the model. We offer realistic assumptions about conflict behaviors that get factored into model-generated scenarios. The scenarios can inform conflict research and strategies for conflict management. We discuss model applications to two-and three-group conflicts. We identify chaotic time evolution of mean attitudes and the occurrence of strange attractors. We examine the role that the range of interactions plays with respect to the occurrence of chaotic behavior

A Solution for Little Hierarchy Problem and b --> s gamma

We show that all the parameters which destabilize the weak scale can be taken around the weak scale in the MSSM without conflicting with the SM Higgs mass bound set by LEP experiment. The essential point is that if the lightest CP-even Higgs h in the MSSM has only a small coupling to Z boson, g_{ZZh}, LEP cannot generate the Higgs sufficiently. In the scenario, the SM Higgs mass bound constrains the mass of the heaviest CP-even Higgs H which has the SM like g_{ZZH} coupling. However, it is easier to make the heaviest Higgs heavy by the effect of off-diagonal elements of the mass matrix of the CP-even Higgs because the larger eigenvalue of 2 times 2 matrix becomes larger by introducing off-diagonal elements. Thus, the smaller stop masses can be consistent with the LEP constraints. Moreover, the two excesses observed at LEP Higgs search can naturally be explained as the signals of the MSSM Higgs h and H in this scenario. One of the most interesting results in the scenario is that all the Higgs in the MSSM have the weak scale masses. For example, the charged Higgs mass should be around 130 GeV. This looks inconsistent with the lower bound obtained by the b --> s gamma process as m_{H^\pm}>350GeV. However, we show that the amplitude induced by the charged Higgs can naturally be compensated by that of the chargino if we take the mass parameters by which the little hierarchy problem can be solved. The point is that the both amplitudes have the same order of magnitudes when all the fields in the both loops have the same order of masses.Comment: 14 pages, 5 figures, input parameter slightly changed, figures replaced, references correcte

Immunization with a Peptide Containing MHC Class I and II Epitopes Derived from the Tumor Antigen SIM2 Induces an Effective CD4 and CD8 T-Cell Response

Here, we sought to determine whether peptide vaccines designed harbor both class I as well as class II restricted antigenic motifs could concurrently induce CD4 and CD8 T cell activation against autologous tumor antigens. Based on our prior genome-wide interrogation of human prostate cancer tissues to identify genes over-expressed in cancer and absent in the periphery, we targeted SIM2 as a prototype autologous tumor antigen for these studies. Using humanized transgenic mice we found that the 9aa HLA-A*0201 epitope, SIM2237–245, was effective at inducing an antigen specific response against SIM2-expressing prostate cancer cell line, PC3. Immunization with a multi-epitope peptide harboring both MHC-I and MHC-II restricted epitopes induced an IFN-γ response in CD8 T cells to the HLA-A*0201-restricted SIM2237–245 epitope, and an IL-2 response by CD4 T cells to the SIM2240–254 epitope. This peptide was also effective at inducing CD8+ T-cells that responded specifically to SIM2-expressing tumor cells. Collectively, the data presented in this study suggest that a single peptide containing multiple SIM2 epitopes can be used to induce both a CD4 and CD8 T cell response, providing a peptide-based vaccine formulation for potential use in immunotherapy of various cancers

E-QED: Electrical Bug Localization During Post-Silicon Validation Enabled by Quick Error Detection and Formal Methods

During post-silicon validation, manufactured integrated circuits are extensively tested in actual system environments to detect design bugs. Bug localization involves identification of a bug trace (a sequence of inputs that activates and detects the bug) and a hardware design block where the bug is located. Existing bug localization practices during post-silicon validation are mostly manual and ad hoc, and, hence, extremely expensive and time consuming. This is particularly true for subtle electrical bugs caused by unexpected interactions between a design and its electrical state. We present E-QED, a new approach that automatically localizes electrical bugs during post-silicon validation. Our results on the OpenSPARC T2, an open-source 500-million-transistor multicore chip design, demonstrate the effectiveness and practicality of E-QED: starting with a failed post-silicon test, in a few hours (9 hours on average) we can automatically narrow the location of the bug to (the fan-in logic cone of) a handful of candidate flip-flops (18 flip-flops on average for a design with ~ 1 Million flip-flops) and also obtain the corresponding bug trace. The area impact of E-QED is ~2.5%. In contrast, deter-mining this same information might take weeks (or even months) of mostly manual work using traditional approaches