VIMOS-VLT spectroscopy of the giant Ly-alpha nebulae associated with three z~2.5 radio galaxies

The morphological and spectroscopic properties of the giant (>60 kpc) Ly-alpha nebulae associated with three radio galaxies at z~2.5 (MRC 1558-003, MRC 2025-218 and MRC 0140-257) have been investigated using integral field spectroscopic data obtained with VIMOS on VLT. The morphologies are varied. The nebula of one source has a centrally peaked, rounded appearance. In the other two objects, it consists of two spatial components. The three nebulae are aligned with the radio axis within <30 deg. The total Ly-alpha luminosities are in the range (0.3-3.4) x 1e44 erg s-1. The Ly-alpha spectral profile shows strong variation through the nebulae, with FWHM values in the range ~400-1500 km s-1 and velocity shifts V~120-600 km s-1. We present an infall model which can explain successfully most Ly-alpha morphological and spectroscopic properties of the nebula associated with MRC 1558-003. This adds further support to our previous conclusion that the _quiescent_ giant nebulae associated with this and other high redshift powerful radio galaxies are in infall. A problem for this model is the difficulty to reproduce the large Ly-alpha FWHM values. We have discovered a giant (~85 kpc) Ly-alpha nebula associated with the radio galaxy MRC 0140-257 at z=2.64. It shows strikingly relaxed kinematics (FWHM2) radio galaxies.Comment: 14 pages, 13 figures. Accepted for publication in MNRA

Discovery of a wide companion near the deuterium burning mass limit in the Upper Scorpius association

We present the discovery of a companion near the deuterium burning mass limit located at a very wide distance, at an angular separation of 4.6+/-0.1 arcsec (projected distance of ~ 670 AU) from UScoCTIO108, a brown dwarf of the very young Upper Scorpius association. Optical and near-infrared photometry and spectroscopy confirm the cool nature of both objects, with spectral types of M7 and M9.5, respectively, and that they are bona fide members of the association, showing low gravity and features of youth. Their masses, estimated from the comparison of their bolometric luminosities and theoretical models for the age range of the association, are 60+/-20 and 14^{+2}_{-8} MJup, respectively. The existence of this object around a brown dwarf at this wide orbit suggests that the companion is unlikely to have formed in a disk based on current planet formation models. Because this system is rather weakly bound, they did not probably form through dynamical ejection of stellar embryos.Comment: 10 pages, including 4 figures and 2 table

Methods and Processes of Developing the Strengthening the Reporting of Observational Studies in Epidemiology – Veterinary (STROBE-Vet) Statement

BACKGROUND Reporting of observational studies in veterinary research presents challenges that often are not addressed in published reporting guidelines. OBJECTIVE To develop an extension of the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement that addresses unique reporting requirements for observational studies in veterinary medicine related to health, production, welfare, and food safety. DESIGN Consensus meeting of experts. SETTING Mississauga, Canada. PARTICIPANTS Seventeen experts from North America, Europe, and Australia. METHODS Experts completed a pre-meeting survey about whether items in the STROBE statement should be modified or added to address unique issues related to observational studies in animal species with health, production, welfare, or food safety outcomes. During the meeting, each STROBE item was discussed to determine whether or not rewording was recommended and whether additions were warranted. Anonymous voting was used to determine consensus. RESULTS Six items required no modifications or additions. Modifications or additions were made to the STROBE items 1 (title and abstract), 3 (objectives), 5 (setting), 6 (participants), 7 (variables), 8 (data sources/measurement), 9 (bias), 10 (study size), 12 (statistical methods), 13 (participants), 14 (descriptive data), 15 (outcome data), 16 (main results), 17 (other analyses), 19 (limitations), and 22 (funding). CONCLUSION The methods and processes used were similar to those used for other extensions of the STROBE statement. The use of this STROBE statement extension should improve reporting of observational studies in veterinary research by recognizing unique features of observational studies involving food-producing and companion animals, products of animal origin, aquaculture, and wildlife

The constant-velocity highly collimated outflows of the planetary nebula He 2-90

We present high-dispersion echelle spectroscopic observations and a narrow-band [N II] image of the remarkable jet-like features of He 2-90. They are detected in the echelle spectra in the H-alpha and [N II] lines but not in other nebular lines. The [N II]/H-alpha ratio is uniformly high, ~1. The observed kinematics reveals bipolar collimated outflows in the jet-like features and shows that the southeast (northwest) component expands towards (away from) the observer at a remarkably constant line-of-sight velocity, 26.0+-0.5 km/s. The observed expansion velocity and the opening angle of the jet-like features are used to estimate an inclination angle of ~5 degrees with respect to the sky plane and a space expansion velocity of ~290 km/s. The spectrum of the bright central nebula reveals a profusion of Fe lines and extended wings of the H-alpha line, similar to those seen in symbiotic stars and some young planetary nebulae that are presumed to host a mass-exchanging binary system. If this is the case for He 2-90, the constant velocity and direction of the jets require a very stable dynamic system against precession and warping.Comment: 8 pages (emulate ApJ), 5 figure, 1 tabl

Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys

Methocinnamox (MCAM), a mu opioid receptor antagonist with a long duration of action, attenuates heroin self-administration in rhesus monkeys, suggesting it could be an effective treatment for opioid use disorder (OUD). This study examined effects of acute and repeated MCAM administration on self-administration of the high-efficacy mu opioid receptor agonist fentanyl and characterized MCAM pharmacokinetics. Four rhesus monkeys self-administered i.v. infusions of fentanyl (0.00032 mg/kg/infusion) or cocaine (0.032 mg/kg/infusion). MCAM (0.1–0.32 mg/kg) or the opioid receptor antagonist naltrexone (0.001–0.032 mg/kg) was injected prior to test sessions to evaluate acute effects. On a separate occasion, 0.32 mg/kg MCAM was injected every 12 days for 5 total injections to evaluate the effectiveness of repeated treatment. Following acute injection, MCAM and naltrexone decreased fentanyl self-administration on the day of treatment, with attenuation lasting for up to 2 weeks after the larger MCAM dose and <1 day after naltrexone. Repeated MCAM administration decreased fentanyl self-administration for more than 2 months without altering cocaine self-administration. MCAM plasma concentrations peaked 15–45 min after injection, with a half-life ranging from 13.7 to 199.8 min, and decreased markedly 1 day after injection. MCAM selectively reduced opioid self-administration and remained effective with repeated administration. Moreover, MCAM was effective at times when plasma levels were very low, suggesting that pharmacodynamic (i.e., pseudoirreversible binding to mu opioid receptors) and not pharmacokinetic factors play a significant role in its long-lasting effects. Taken together with previous studies, these data indicate that MCAM could be a safe, effective, and long-acting treatment for OUD

Comparison of Bond Character in Hydrocarbons and Fullerenes

We present a comparison of the bond polarizabilities for carbon-carbon bonds in hydrocarbons and fullerenes, using two different models for the fullerene Raman spectrum and the results of Raman measurements on ethane and ethylene. We find that the polarizabilities for single bonds in fullerenes and hydrocarbons compare well, while the double bonds in fullerenes have greater polarizability than in ethylene.Comment: 7 pages, no figures, uses RevTeX. (To appear in Phys. Rev. B.

A direct probe of cosmological power spectra of the peculiar velocity field and the gravitational lensing magnification from photometric redshift surveys

The cosmological peculiar velocity field (deviations from the pure Hubble flow) of matter carries significant information on dark energy, dark matter and the underlying theory of gravity on large scales. Peculiar motions of galaxies introduce systematic deviations between the observed galaxy redshifts z and the corresponding cosmological redshifts z_cos. A novel method for estimating the angular power spectrum of the peculiar velocity field based on observations of galaxy redshifts and apparent magnitudes m (or equivalently fluxes) is presented. This method exploits the fact that a mean relation between z_cos and m of galaxies can be derived from all galaxies in a redshift-magnitude survey. Given a galaxy magnitude, it is shown that the z_cos(m) relation yields its cosmological redshift with a 1-sigma error of sigma_z~0.3 for a survey like Euclid (~10^9 galaxies at z<~2), and can be used to constrain the angular power spectrum of z-z_cos(m) with a high signal-to-noise ratio. At large angular separations corresponding to l<~15, we obtain significant constraints on the power spectrum of the peculiar velocity field. At 15<~l<~60, magnitude shifts in the z_cos(m) relation caused by gravitational lensing magnification dominate, allowing us to probe the line-of-sight integral of the gravitational potential. Effects related to the environmental dependence in the luminosity function can easily be computed and their contamination removed from the estimated power spectra. The amplitude of the combined velocity and lensing power spectra at z~1 can be measured with <~5% accuracy.Comment: 22 pages, 3 figures; added a discussion of systematic errors, accepted for publication in JCA

Measurements of a low temperature mechanical dissipation peak in a single layer of Ta2O5 doped with TiO2

Thermal noise arising from mechanical dissipation in oxide coatings is a major limitation to many precision measurement systems, including optical frequency standards, high resolution optical spectroscopy and interferometric gravity wave detectors. Presented here are measurements of dissipation as a function of temperature between 7 K and 290 K in ion-beam sputtered Ta2O5 doped with TiO2, showing a loss peak at 20 K. Analysis of the peak provides the first evidence of the source of dissipation in doped Ta2O5 coatings, leading to possibilities for the reduction of thermal noise effects

Library of Seleno-Compounds as Novel Agents against Leishmania Species

The in vitro leishmanicidal activities of a series of 48 recently synthesized selenium derivatives against Leishmania infantum and Leishmania braziliensis parasites were tested using promastigotes and intracellular amastigote forms. The cytotoxicity of the tested compounds for J774.2 macrophage cells was also measured in order to establish their selectivity. Six of the tested compounds (compounds 8, 10, 11, 15, 45, and 48) showed selectivity indexes higher than those of the reference drug, meglumine antimonate (Glucantime), for both Leishmania species; in the case of L. braziliensis, compound 20 was also remarkably selective. Moreover, data on infection rates and amastigote numbers per macrophage showed that compounds 8, 10, 11, 15, 45, and 48 were the most active against both Leishmania species studied. The observed changes in the excretion product profile of parasites treated with these six compounds were also consistent with substantial cytoplasmic alterations. On the other hand, the most active compounds were potent inhibitors of Fe superoxide dismutase (Fe-SOD) in the two parasite species considered, whereas their impact on human CuZn-SOD was low. The high activity, low toxicity, stability, low cost of the starting materials, and straightforward synthesis make these compounds appropriate molecules for the development of affordable antileishmanicidal agents