LANDSLIDES AND POCKFORMS OF SOUTHERN SARDINIAN MARGIN

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CONTINENTAL SHELF AND SLOPE GEOMORPHOLOGY: MARINE SLUMPING INDUCED BY HYPERPYCNAL FLOWS (SARDINIAN SOUTHERN CONTINENTAL MARGIN)

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HABITAT MAPPING AND PALAEO-SEALEVELS OF THE LAST GLACIAL MAXIMUM COASTLINE ON THE SAN PIETRO CONTINENTAL SHELF (SW SARDINIA)

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Morfologia e dinamica delle frane sottomarine potenzialmente tzunamogeniche del margine meridionale sardo (Progetto MAGIC)

Tsunamis are tipically related to several triggering events including earthquakes generated along subduction zones extending up to several hundreds kilometers in lenght, the gravitational massive collapse of volcanic buildings, cliffs or submarine landslides (TINTI ET ALII, 1999; FRYER ET ALII, 2004; MCADOO &WATTS, 2004). Until recent years, tsunamis associated with gravitational events, have been considered very rare, restricted to limited areas and with less energy than the earthquakes generated tsunamis. Recent studies show that the landslides produced tsunamis can be frequent as much as those induced by earthquakes and are also able to generate extreme waves that may affect coastal areas (MCMURTHY ET ALII, 2004; LEE ET ALII, 2007). Considering the actual population growth and industrialization of coastal areas, these are important data implying that tsunami hazard should be studied not only in tectonically active areas, but also in passive margin contexts where gravitational processes can frequently occur (GARZIGLIA ET ALII, 2007). Within the MAGIC project (Marine Geohazard Along the Italian Coast) during the “Sardegna 2009” and “Sardegna 2010” cruises, carried out with the R/V “Universitatis”, multibeam surveys with RESON 8160, high resolution seismic surveys by CHIRP Subbottom ( 500Hz/13,5kHz) and sparker surveys APPLIED ACOUSTICCSP2200 (10/2000 J) were carried out in the southern and western Sardinian margin at depths between -50 and -2200 m. In this work several complex landslides, detected in the upper Sulcis slope and in the Cagliari gulf were analyzed

Multidisciplinary and multiscalar approach for a sustainable management of Red Coral (Corallium rubrum,L.1758) from the island of Sardinia (West Mediterranean Sea)

Red Coral, Corallium rubrum (L.1758), is an important socio-economic resource for the Mediterranean community and the island of Sardinia, due to its great commercial value. Since 1979, regional law regulates colonies harvesting for its correct management and conservation. Nevertheless, all available data that provided the scientific base for the actual law, came from landing data obtained from fishermen, leaving huge lacks of knowledge in terms of investigated areas (and relative geological features) and representativeness of the state of the stock. In this work we report an example of multidisciplinary and approach, both biological and geological, for an unprecedented multiscalar mapping of red coral colonies that can provide important improvement in its conservation. A Geological survey (“MaGIC” project, Marine Geohazard along Italian Coasts) using Multibeam, Side Scan Sonar and Sparker 500J was conducted in Summer 2009, providing a detailed data coverage of two key areas of South Sardinia continental shelf San Pietro Island and Cape Carbonara. Data collected during the survey were integrated with CARG project (Official National Italian Geological Cartography). This Geomorphological analysis provided a usefull guideline to define and map harvesting areas and planning the further ROV survey. The Biological R.O.V survey was carried out in Summer 2011; more than 2000 photos were Geo-referenced to the multibeam map of the bottom, and examined using CPCe (Coral Point Count with Excel extensions) Software in order to create a database on the abundance and morphometry of colonies. Colonies were divided in 3 categories: Ramified, non ramified and dead colonies. For the morphometric database, the basal diameter and maximum height of the colony was measured along with number and type of ramifications. The population structure was also calculated for better describe the status of the stock. This mapping approach has allowed scientist to discover new banks of coral that can could be harvested in a short/long- time period in less known areas as well as a better overview of sites already used for harvesting. Morphological adaptations of Red coral colonies to environmental features can be evaluated thanks to to the multibeam references. In conclusion these data can provide the new scientific base for a local-based specific regulation for C.rubrum harvesting

Automated radiosynthesis and preclinical evaluation of two new PSMA-617 derivatives radiolabelled via [18F]AlF2+ method

Abstract Background In the last decade the development of new PSMA-ligand based radiopharmaceuticals for the imaging and therapy of prostate cancer has been a highly active and important area of research. The most promising derivative in terms of interaction with the antigen and clinical properties has been found to be “PSMA-617”, and its lutetium-177 radiolabelled version has recently been approved by EU and USA regulatory agencies for therapeutic purposes. For the above reasons, the development of new derivatives of PSMA-617 radiolabelled with fluorine-18 may still be of great interest. This paper proposes the comparison of two different PSMA-617 derivatives functionalized with NODA and RESCA chelators, respectively, radiolabelled via [18F]AlF2+ complexation. Results The organic synthesis of two PSMA-617 derivatives and their radiolabelling via [18F]AlF2+ complexation resulted to proceed efficiently and successfully. Moreover, stability in solution and in plasma has been evaluated. The whole radiosynthesis procedure has been fully automated, and the final products have been obtained with radiochemical yield and purity potentially suitable for clinical studies. The biodistribution of the two derivatives was performed both in prostate cancer and glioma tumour models. Compared with the reference [18F]F-PSMA-1007 and [18F]F-PSMA-617-RESCA, [18F]F-PSMA-617-NODA derivative showed a higher uptake in both tumors, faster clearance in non-target organs, and lower uptake in salivary glands. Conclusion PSMA-617 NODA and RESCA derivatives were radiolabelled successfully via [18F]AlF2+ chelation, the former being more stable in solution and human plasma. Moreover, preclinical biodistribution studies showed that [18F]F-PSMA-617-NODA might be of potential interest for clinical applications