1 research outputs found
Permission to Enter Cell by Shape: Nanodisk vs Nanosphere
Changing polystyrene nanoparticles from three-dimensional
spherical
shape to two-dimensional disk shape promotes their cell surface binding
with significant reduction of cell uptake. As a result of lower cell
uptake, nanodisks show very little perturbations on cell functions
such as cellular ROS generation, apoptosis and cell cycle progression
compared to nanospheres. Therefore, disk-shaped nanoparticles may
be a promising template for developing cell membrane-specific and
safer imaging agents for a range of biomedical applications such as
molecular imaging, tissue engineering, cell tracking, and stem cell
separation