Univariate predictors and multivariate regression model in quiet state.

<p>Coefficient of determination R² (training set/validation set in the multivariate model), standardized regression coefficient beta, slope (95% confidence interval) of the models, significance.</p>*<p>pNN5 was included only in the backward modeling.</p

Mean heart rate (meanHR) vs. chronological age in active sleep.

<p>Normals ○, intrauterine growth retarded (IUGR) group •. For group comparison see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074431#pone-0074431-t007" target="_blank">Table 7</a>.</p

Fetal autonomic brain age score (fABAS) vs. chronological age in active sleep.

<p>Normals ○, intrauterine growth retarded (IUGR) group •. For group comparison see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074431#pone-0074431-t007" target="_blank">Table 7</a>.</p

Discrimination of IUGR and normal group by means of bivariate logistic regression models that include [fABAS, WGA] and [meanHR, WGA], respectively.

<p>Regression coefficient B, standard error SE, Wald test statistic with significance level p, odds ratio OR (95% confidence interval), correct classification rate.</p

State classification results of logistic regression models.

<p>State classification results of logistic regression models.</p

Fetal autonomic brain age score (fABAS) versus chronological age in active sleep of females ○ and males •.

<p>For gender comparison see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074431#pone-0074431-t005" target="_blank">Table 5</a>.</p

Univariate predictors and multivariate regression model in active state.

<p>Coefficient of determination R² (training set/validation set in the multivariate model), standardized regression coefficient beta, slope (95% confidence interval) of the models, significance.</p

Contribution of WGA and sex to the variance of fABAS (ANOVA models).

<p>Contribution of WGA and sex to the variance of fABAS (ANOVA models).</p

Neonatal outcome characteristics, mean (standard deviation), [min-max].

<p>Neonatal outcome characteristics, mean (standard deviation), [min-max].</p

Developmental milestones of the autonomic nervous system revealed via longitudinal monitoring of fetal heart rate variability - Fig 2

<p><b>Developmental course of gMSE(3) (a, b) and skewness (c, d) in the linear mixed model.</b> (a) unclassified datasets: SoI {1–2} χ² = 11,81; p<0.001, SoI {2–3} χ² = 10.04; p = 0.0013; (b) fetal active sleep SoI {1–2} χ² = 6.7, p = 0.0096, SoI {2–3} χ² = 12.17, p<0.001; (c) unclassified datasets: SoI {1–2} χ² = 70.31, p<0.0001, SoI {2–3} χ² = 21.29, p<0.001, SoI {3–4} χ² = 3.16, p = 0.076; (d) fetal active sleep: SoI {1–2} χ² = 35.50, p<0.0001, SoI {2–3} χ² = 21.13, p<0.0001. x–Segment of Interest {< 27 WGA; 27–30 WGA; 31–35 WGA;>35 WGA}; completed weeks of GA; y–Estimator in [bit_norm] Significant (p<0.05) contrasts are marked by *, trends (p<0.10) by +. Results for ‘fetal quiescence’ are not shown because they did not reach significant levels (gMSE(3): SoI {2–3}, χ² = 3.41; p = 0.07).</p