Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.

Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype. Here we compare the genome-scale proteomic and transcriptomic changes in human primary haematopoietic stem/progenitor cells and erythroid progenitors, and uncover pathways related to mitochondrial biogenesis enhanced through post-transcriptional regulation. Mitochondrial factors including TFAM and PHB2 are selectively regulated through protein translation during erythroid specification. Depletion of TFAM in erythroid cells alters intracellular metabolism, leading to elevated histone acetylation, deregulated gene expression, and defective mitochondria and erythropoiesis. Mechanistically, mTORC1 signalling is enhanced to promote translation of mitochondria-associated transcripts through TOP-like motifs. Genetic and pharmacological perturbation of mitochondria or mTORC1 specifically impairs erythropoiesis in vitro and in vivo. Our studies support a mechanism for post-transcriptional control of erythroid mitochondria and may have direct relevance to haematologic defects associated with mitochondrial diseases and ageing

Probing Anomalous Wtb Coupling via Single Top Production at TeV Energy γ\gamma e Colliders

Results of complete tree level calculations of the single top production reaction $\gamma e \to \nu \bar{t} b$ at the Next Linear Collider, including the contribution of anomalous operators to the Wtb coupling are presented. The sensitivity for probing the structure of the Wtb coupling in a model independent way is analyzed and found to be significantly higher than for comparable measurements at the Tevatron.Comment: 10 Latex pages including 1 ps-figure and 3 eps-figure

1+1 dimensional QCD with fundamental bosons and fermions

We analyze the properties of mesons in 1+1 dimensional QCD with bosonic and fermionic ``quarks'' in the large \nc limit. We study the spectrum in detail and show that it is impossible to obtain massless mesons including boson constituents in this model. We quantitatively show how the QCD mass inequality is realized in two dimensional QCD. We find that the mass inequality is close to being an equality even when the quarks are light. Methods for obtaining the properties of ``mesons'' formed from boson and/or fermion constituents are formulated in an explicit manner convenient for further study. We also analyze how the physical properties of the mesons such as confinement and asymptotic freedom are realized.Comment: 20 pages, harvmac, 5 figure

Structure formation constraints on the Jordan-Brans-Dicke theory

We use cosmic microwave background data from WMAP, ACBAR, VSA and CBI, and galaxy power spectrum data from 2dF, to constrain flat cosmologies based on the Jordan-Brans-Dicke theory, using a Markov Chain Monte Carlo approach. Using a parametrization based on \xi=1/4\omega, and performing an exploration in the range \ln\xi \in [-9,3], we obtain a 95% marginalized probability bound of \ln\xi < -6.2, corresponding to a 95% marginalized probability lower bound on the Brans-Dicke parameter \omega>120.Comment: 6 pages, 5 figures, RevTeX. Updated to match version accepted by PRD. Significant updates. Headline constraint tightened to omega > 120 (95% conf) by improved statistical analysi

A Strong-Coupling Analysis of the Lattice CPN−1CP^{N-1} Models in the Presence of a θ\theta Term

A $\theta$ term, which couples to topological charge, is added to the lattice $CP^{N-1}$ model. The strong-coupling character expansion is developed. The series for the free energy and mass gap are respectively computed to tenth order and fourth order. Several features of the strong-coupling analysis emerge. One is the loss of superconfinement. Another is that in the intermediate coupling constant region, there are indications of a transition to a deconfining phase when $\theta$ is sufficiently large. The transition is like the one which has been observed in Monte Carlo simulations of a similar lattice $CP^{N-1}$ action.Comment: Latex file, 19 pages plus a postscript file of 4 figures, to appear in Physical Review

Screening of the topological charge in a correlated instanton vacuum

Screening of the topological charge due to he fermion-induced interactions is an important phenomenon, closely related with the resolution of the strong CP and U(1) problems. We study the mechanism of such screening in a 'correlated instanton vacuum', as opposed to the 'random' one. Both scalar and pseudoscalar gluonic correlators are analyzed by means of an observable that minimizes finite size effects. Screening of the topological charge is established. This allows us to calculate the $\eta'$ mass without having to invert the Dirac operator. We suggest that this method might be used in lattice QCD calculations as well. Our results for the screening of the topological charge are in agreement with the chiral Ward identities, and the scalar gluonic correlator satisfies a low energy theorem first derived by Novikov et al. \cite{Novikov-etal}. We also propose to evaluate the topological susceptibility in the Witten-Veneziano formula not in an infinite box in an world $without$ fermions but in an infinitesimal box in a world $with$ fermions.Comment: 22 pages + 5 postscript figures, SUNY-NTG/94-25. Corrected LATEX erro

Binary inspiral, gravitational radiation, and cosmology

Observations of binary inspiral in a single interferometric gravitational wave detector can be cataloged according to signal-to-noise ratio $\rho$ and chirp mass $\cal M$. The distribution of events in a catalog composed of observations with $\rho$ greater than a threshold $\rho_0$ depends on the Hubble expansion, deceleration parameter, and cosmological constant, as well as the distribution of component masses in binary systems and evolutionary effects. In this paper I find general expressions, valid in any homogeneous and isotropic cosmological model, for the distribution with $\rho$ and $\cal M$ of cataloged events; I also evaluate these distributions explicitly for relevant matter-dominated Friedmann-Robertson-Walker models and simple models of the neutron star mass distribution. In matter dominated Friedmann-Robertson-Walker cosmological models advanced LIGO detectors will observe binary neutron star inspiral events with $\rho>8$ from distances not exceeding approximately $2\,\text{Gpc}$, corresponding to redshifts of $0.48$ (0.26) for $h=0.8$ ($0.5$), at an estimated rate of 1 per week. As the binary system mass increases so does the distance it can be seen, up to a limit: in a matter dominated Einstein-deSitter cosmological model with $h=0.8$ ($0.5$) that limit is approximately $z=2.7$ (1.7) for binaries consisting of two $10\,\text{M}_\odot$ black holes. Cosmological tests based on catalogs of the kind discussed here depend on the distribution of cataloged events with $\rho$ and $\cal M$. The distributions found here will play a pivotal role in testing cosmological models against our own universe and in constructing templates for the detection of cosmological inspiraling binary neutron stars and black holes.Comment: REVTeX, 38 pages, 9 (encapsulated) postscript figures, uses epsf.st

Decay of Metastable Topological Defects

We systematically analyze the decay of metastable topological defects that arise from the spontaneous breakdown of gauge or global symmetries. Quantum-mechanical tunneling rates are estimated for a variety of decay processes. The decay rate for a global string, vortex, domain wall, or kink is typically suppressed compared to the decay rate for its gauged counterpart. We also discuss the decay of global texture, and of semilocal and electroweak strings.Comment: 43 pages, harvmac, HUTP-92/A018, CALT-68-178

False vacuum decay with gravity in a critical case

The vacuum decay in a de Sitter universe is studied within semiclassical approximation for the class of effective inflaton potentials whose curvature at the top is close to a critical value. By comparing the actions of the Hawking - Moss instanton and the Coleman - de Luccia instanton(s) the mode of vacuum decay is determined. The case when the fourth derivative of the effective potential at its top is less than a critical value is discussed.Comment: 10 pages, 8 figures, minor changes don

Minimal Conformal Technicolor and Precision Electroweak Tests

We study the minimal model of conformal technicolor, an SU(2) gauge theory near a strongly coupled conformal fixed point, with conformal symmetry softly broken by technifermion mass terms. Conformal symmetry breaking triggers chiral symmetry breaking in the pattern SU(4) -> Sp(4), which gives rise to a pseudo-Nambu-Goldstone boson that can act as a composite Higgs boson. The top quark is elementary, and the top and electroweak gauge loop contributions to the Higgs mass are cut off entirely by Higgs compositeness. In particular, the model requires no top partners and no "little Higgs" mechanism. A nontrivial vacuum alignment results from the interplay of the top loop and technifermion mass terms. The composite Higgs mass is completely determined by the top loop, in the sense that m_h/m_t is independent of the vacuum alignment and is computable by a strong-coupling calculation. There is an additional composite pseudoscalar A with mass larger than m_h and suppressed direct production at LHC. We discuss the electroweak fit in this model in detail. Corrections to Z -> bb and the T parameter from the top sector are suppressed by the enhanced Sp(4) custodial symmetry. Even assuming that the strong contribution to the S parameter is positive and usuppressed, a good electroweak fit can be obtained for v/f ~ 0.25, where v and f are the electroweak and chiral symmetry breaking scales respectively. This requires fine tuning at the 10% level.Comment: 34 pages, 4 figures; v2: updated precision electroweak fi