1 research outputs found
Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus
Toll-like receptor (TLR) 7 and 8
agonists can potentially be used
in the treatment of viral infections and are particularly promising
for chronic hepatitis B virus (HBV) infection. An internal screening
effort identified a pyrimidine Toll-like receptor 7 and 8 dual agonist.
This provided a novel alternative over the previously reported adenine
and pteridone type of agonists. Structure–activity relationship,
lead optimization, in silico docking, pharmacokinetics, and demonstration
of ex vivo and in vivo cytokine production of the lead compound are
presented