1 research outputs found
Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides
Functional nucleotides are important
in many cutting-edge biomolecular
techniques. Often several modified nucleotides have to be incorporated
consecutively. This structural study of KlenTaq DNA polymerase, a
truncated form of <i>Thermus aquaticus</i> DNA polymerase,
gives first insights how multiple modifications are processed by a
DNA polymerase and, therefore, contribute to the understanding of
these enzymes in their interplay with artificial substrates