306 research outputs found
TRIPS implementation and secondary pharmaceutical patenting in Brazil and India
This article compares national approaches toward secondary pharmaceutical patents. Because secondary patents can extend periods of exclusivity and delay generic competition, they can raise prices and reduce access to medicines. Little is known about what measures countries have enacted policies to address applications for secondary pharmaceutical patents, how they function, and whether, in practice, these measures limit secondary patents. We analyze the cases of India and Brazil. We assemble data on pharmaceutical patent applications filed in the two countries, code each application to identify which constitute secondary applications, and examine outcomes for each application in both countries. The data indicate that Brazil is less likely to grant applications than India, but in both countries the measures designed to limit secondary patents are having little direct effect. This suggests, on the one hand, that critics of these policies, such as the transnational pharmaceutical sector and foreign governments, may be more worried than they should be. On the other hand, champions of the policies, such as NGOs and international organizations, may have cause for concern that laws on the books are not having the expected impact on patent outcomes in practice. Our findings also suggest that, at the drug level, the effects of countriesâ approaches toward secondary patents need to be understood in the context of their broader approaches toward TRIPS implementation, including when and how they introduced pharmaceutical patents in the 1990s and 2000s
Effect of wettability on hydrodynamics and mass transfer in small capillaries
The wettability of the reactor wall has a significant effect on the interfacial liquidâliquid mass transfer rates in segmented flow. This work quantitatively demonstrates the importance of choosing the right material of construction of flow reactors to achieve the desired mass transfer performance. Glass and PTFE capillaries of identical diameter were used to study the effect of hydrophilic and hydrophobic surfaces on the hydrodynamics and mass transfer of the system. It was observed that for the overall mass transfer coefficient (kLa) changed by two orders of magnitude depending on the wettability of the continuous phase. The observations indicated that it is essential to achieve complete wetting of the capillary walls by the continuous phase for significant mass transfer enhancement. The observations are discussed on the basis of film thickness and slip velocity at the wall as well as the slip velocity at liquidâliquid interface. Predictions of the mass transfer coefficient using a model based on the interfacial and fluid properties showed excellent match with the experiments thereby allowing us to explore the effects of wettability on the overall mass transfer coefficient in greater detail
Indian pharmaceutical patent prosecution: The changing role of Section 3(d)
India, like many developing countries, only recently began to grant pharmaceutical product patents. Indian patent law includes a provision, Section 3(d), which tries to limit grant of âsecondaryâ pharmaceutical patents, i.e. patents on new forms of existing molecules and drugs. Previous research suggests the provision was rarely used against secondary applications in the years immediately following its enactment, and where it was, was redundant to other aspects of the patent law, raising concerns that 3(d) was being under-utilized by the Indian Patent Office. This paper uses a novel data source, the patent officeâs first examination reports, to examine changes in the use of the provision. We find a sharp increase over time in the use of Section 3(d), including on the main claims of patent applications, though it continues to be used in conjunction with other types of objections to patentability. More surprisingly, see a sharp increase in the use of the provision against primary patent applications, contrary to its intent, raising concerns about potential over-utilization
Drug patenting in India: looking back andlooking forward
It has now been 20 years since the TRIPS Agreement, which established minimum standards for intellectual property (IP) regulation, came into force. Its implementation in India has been controversial, and in particular Section 3(d), a provision designed to restrict the grant of âsecondaryâ patents, has been pinpointed as making it difficult to obtain pharmaceutical patents. Ken Shadlen and Bhaven Sampat suggest that paying so much attention to 3(d) may be misplaced. They argue that another, more fundamental, aspect of TRIPS implementation in India, the timing of the countryâs adoption of pharmaceutical patents, is more important than 3(d) for understanding the current patenting landscape. And because the effects of timing are transitional, in the future it may be less difficult to obtain patents in India than is widely thought
Patents, trade, and medicines: past, present, and future
This article analyzes the spread of intellectual property in trade agreements. We explain how the integration of intellectual property with international trade rules led to the globalization of pharmaceutical patenting, and then how additional provisions related to pharmaceutical products have been introduced by regional and bilateral trade agreements. We describe the additional âTRIPS-Plusâ rules contained in recent trade agreements, which go beyond the requirements of the World Trade Organizationâs TRIPS Agreement, and explain the potential challenges that they may create for developing countries. We draw attention to the conceptual and methodological challenges of assessing the effects of patent provisions in trade agreements on prices and access to drugs, with particular emphasis on the importance of timing. Depending on when countries began allowing drugs to be patented, TRIPS-Plus provisions have different effects; and when pharmaceutical patenting has been in place for more countries for more time, the effects of TRIPS-Plus provisions will change again
Balancing innovation and access: Indiaâs pharmaceutical patent laws
Writing in Science, LSEâs Kenneth Shadlen, Bhaven Sampat (Columbia) and Tahir Amin (Harvard) debate the implications of an upcoming Indian Supreme Court decision on pharmaceutical patents for variants of existing compounds and its impact on the accessibility of affordable drugs
Nematicidal, Fungicidal and Bactericidal Activities of Manganese (II) Complexes with Heterocyclic Sulphonamide Imines
Some manganese(II) complexes derived from different sulphadrugs and heterocyclic ketones have been
prepared. These complexes have been characterized on the basis of elemental analyses, molecular weight
determinations, conductivity measurements, infrared, ESR and magnetic measurements. The spectral data
suggest that the ligands act in a monobasic, bidentate manner coordinating through nitrogen atom. A high
spin tetrahedral geometry around this metal has been proposed on the basis of magnetic and spectral studies. The isolated products are coloured solids, soluble in DMSO, DMF and MeOH. All the complexes are
monomeric in nature as indicated by their molecular weight determinations and conductivity measurements
in dry DMF show them to be non-electrolytes. All the ligands and their corresponding complexes have been
screened for their fungicidal, bactericidal and nematicidal activities
Secondary pharmaceutical patenting: a global perspective
Pharmaceutical firmsâ use of secondary patents to extend periods of exclusivity generates concerns among policymakers worldwide. In response, some developing countries have introduced measures to curb the grant of these patents. While these measures have received considerable attention, there is limited evidence on their effectiveness. We follow a large sample of international patent applications in the US, Japan, the European Patent Office, and corresponding filings in three developing countries with restrictions on secondary patents, India, Brazil, and Argentina. We examine cross-country comparisons of primary vs. secondary grant rates, consider the differential fates of âtwinâ applications filed in multiple countries, and undertake detailed analyses of patent prosecution in the three developing countries. Our analyses indicate that measures to restrict secondary patents in developing countries are having limited impact. In none of these three countries are specific policies toward secondary patents the principal determinant of grant rates. Our analyses also suggest the importance of other procedural aspects of patent systems, beyond the formal policies targeting secondary applications, that affect outcomes for these applications in developing countries
Perceptual Embedding Consistency for Seamless Reconstruction of Tilewise Style Transfer
Style transfer is a field with growing interest and use cases in deep
learning. Recent work has shown Generative Adversarial Networks(GANs) can be
used to create realistic images of virtually stained slide images in digital
pathology with clinically validated interpretability. Digital pathology images
are typically of extremely high resolution, making tilewise analysis necessary
for deep learning applications. It has been shown that image generators with
instance normalization can cause a tiling artifact when a large image is
reconstructed from the tilewise analysis. We introduce a novel perceptual
embedding consistency loss significantly reducing the tiling artifact created
in the reconstructed whole slide image (WSI). We validate our results by
comparing virtually stained slide images with consecutive real stained tissue
slide images. We also demonstrate that our model is more robust to contrast,
color and brightness perturbations by running comparative sensitivity analysis
tests
Snakules: A Model-Based Active Contour Algorithm for the Annotation of Spicules on Mammography
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