8 research outputs found
Metal- and Solvent-Free Approach to Diversely Substituted Picolinates via Domino Reaction of Cyclic Sulfamidate Imines with β,γ-Unsaturated α‑Ketocarbonyls
An
efficient, solvent-free, and eco-friendly domino reaction of
5/6-membered cyclic sulfamidate imines with a variety of β,γ-unsaturated
α-ketocarbonyls in neat conditions under MW irradiation promoted
by DABCO as a solid organobase has been developed for the rapid construction
of a novel class of densely functionalized picolinates. This interesting
metal–solvent-free tactic allows a wide range of useful functionalities
on the aryl rings and delivers good to excellent yields of the aforesaid
aza-heterocycles within short time spans (20–40 min). A biologically
promising imidazoÂ[1,2-<i>a</i>]Âpyridine was successfully
synthesized through our unique procedure
Access to 4,6-Diarylpicolinates via a Domino Reaction of Cyclic Sulfamidate Imines with Morita–Baylis–Hillman Acetates of Nitroolefins/Nitrodienes
An
interesting domino reaction of 5-membered cyclic sulfamidate
imines with a variety of Morita–Baylis–Hillman acetates
of nitroolefins/nitrodienes in the presence of DABCO as an organic
base at 55 °C is reported for the first time. This new synthetic
strategy provides a series of pharmacologically interesting 4,6-diarylpicolinates
in high to excellent yields and allows several compatible functionalities
on aryl rings. Moreover, the biologically interesting imidazoÂ[1,2-<i>a</i>]Âpyridine (alpidem derivative) has been prepared in high
chemical yield through a unique procedure
Access to 4,6-Diarylpicolinates via a Domino Reaction of Cyclic Sulfamidate Imines with Morita–Baylis–Hillman Acetates of Nitroolefins/Nitrodienes
An
interesting domino reaction of 5-membered cyclic sulfamidate
imines with a variety of Morita–Baylis–Hillman acetates
of nitroolefins/nitrodienes in the presence of DABCO as an organic
base at 55 °C is reported for the first time. This new synthetic
strategy provides a series of pharmacologically interesting 4,6-diarylpicolinates
in high to excellent yields and allows several compatible functionalities
on aryl rings. Moreover, the biologically interesting imidazoÂ[1,2-<i>a</i>]Âpyridine (alpidem derivative) has been prepared in high
chemical yield through a unique procedure
Stereoselective Synthesis of 3,3-Disubstituted Oxindoles and Spirooxindoles via Allylic Alkylation of Morita–Baylis–Hillman Carbonates of Isatins with Cyclic Sulfamidate Imines Catalyzed by DABCO
An
efficient, organocatalytic, and ecofriendly method has been
developed for the quick construction of a wide array of 3,3-disubstituted
oxindoles in good to excellent yields and diastereomeric ratio (up
to ≤96:4) with excellent functional group tolerance via an
allylic alkylation reaction of cyclic sulfamidate imines with a number
of MBH carbonates of isatins in 2-MeTHF as an environmentally benign
solvent at room temperature using 5 mol % of DABCO. Furthermore, a
metal-free-based one-shot synthesis of a medicinally promising polycyclic
spirooxindole with an all-carbon spirocenter has been achieved with
outstanding dr value (up to ≤99:1)
Stereoselective Synthesis of 3,3-Disubstituted Oxindoles and Spirooxindoles via Allylic Alkylation of Morita–Baylis–Hillman Carbonates of Isatins with Cyclic Sulfamidate Imines Catalyzed by DABCO
An
efficient, organocatalytic, and ecofriendly method has been
developed for the quick construction of a wide array of 3,3-disubstituted
oxindoles in good to excellent yields and diastereomeric ratio (up
to ≤96:4) with excellent functional group tolerance via an
allylic alkylation reaction of cyclic sulfamidate imines with a number
of MBH carbonates of isatins in 2-MeTHF as an environmentally benign
solvent at room temperature using 5 mol % of DABCO. Furthermore, a
metal-free-based one-shot synthesis of a medicinally promising polycyclic
spirooxindole with an all-carbon spirocenter has been achieved with
outstanding dr value (up to ≤99:1)
Stereoselective Synthesis of 3,3-Disubstituted Oxindoles and Spirooxindoles via Allylic Alkylation of Morita–Baylis–Hillman Carbonates of Isatins with Cyclic Sulfamidate Imines Catalyzed by DABCO
An
efficient, organocatalytic, and ecofriendly method has been
developed for the quick construction of a wide array of 3,3-disubstituted
oxindoles in good to excellent yields and diastereomeric ratio (up
to ≤96:4) with excellent functional group tolerance via an
allylic alkylation reaction of cyclic sulfamidate imines with a number
of MBH carbonates of isatins in 2-MeTHF as an environmentally benign
solvent at room temperature using 5 mol % of DABCO. Furthermore, a
metal-free-based one-shot synthesis of a medicinally promising polycyclic
spirooxindole with an all-carbon spirocenter has been achieved with
outstanding dr value (up to ≤99:1)
Stereoselective Synthesis of 3,3-Disubstituted Oxindoles and Spirooxindoles via Allylic Alkylation of Morita–Baylis–Hillman Carbonates of Isatins with Cyclic Sulfamidate Imines Catalyzed by DABCO
An
efficient, organocatalytic, and ecofriendly method has been
developed for the quick construction of a wide array of 3,3-disubstituted
oxindoles in good to excellent yields and diastereomeric ratio (up
to ≤96:4) with excellent functional group tolerance via an
allylic alkylation reaction of cyclic sulfamidate imines with a number
of MBH carbonates of isatins in 2-MeTHF as an environmentally benign
solvent at room temperature using 5 mol % of DABCO. Furthermore, a
metal-free-based one-shot synthesis of a medicinally promising polycyclic
spirooxindole with an all-carbon spirocenter has been achieved with
outstanding dr value (up to ≤99:1)
Stereoselective Synthesis of 3,3-Disubstituted Oxindoles and Spirooxindoles via Allylic Alkylation of Morita–Baylis–Hillman Carbonates of Isatins with Cyclic Sulfamidate Imines Catalyzed by DABCO
An
efficient, organocatalytic, and ecofriendly method has been
developed for the quick construction of a wide array of 3,3-disubstituted
oxindoles in good to excellent yields and diastereomeric ratio (up
to ≤96:4) with excellent functional group tolerance via an
allylic alkylation reaction of cyclic sulfamidate imines with a number
of MBH carbonates of isatins in 2-MeTHF as an environmentally benign
solvent at room temperature using 5 mol % of DABCO. Furthermore, a
metal-free-based one-shot synthesis of a medicinally promising polycyclic
spirooxindole with an all-carbon spirocenter has been achieved with
outstanding dr value (up to ≤99:1)