Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2,3-dihydroisoindolin-1-one fragment as ligands of integrin αIIbβ3

AbstractA series of novel RGD mimetics containing phthalimidine fragment was designed and synthesized. Their antiaggregative activity determined by Born’s method was shown to be due to inhibition of fibrinogen binding to αIIbβ3. Molecular docking of RGD mimetics to αIIbβ3 receptor showed the key interactions in this complex, and also some correlations have been observed between values of biological activity and docking scores. The single crystal X-ray data were obtained for five mimetics

The Polarised Valence Quark Distribution from semi-inclusive DIS

The semi-inclusive difference asymmetry A^{h^{+}-h^{-}} for hadrons of opposite charge has been measured by the COMPASS experiment at CERN. The data were collected in the years 2002-2004 using a 160 GeV polarised muon beam scattered off a large polarised ^6LiD target and cover the range 0.006 < x < 0.7 and 1 < Q^2 < 100 (GeV/c)^2. In leading order QCD (LO) the asymmetry A_d^{h^{+}-h^{-}} measures the valence quark polarisation and provides an evaluation of the first moment of Delta u_v + Delta d_v which is found to be equal to 0.40 +- 0.07 (stat.) +- 0.05 (syst.) over the measured range of x at Q^2 = 10 (GeV/c)^2. When combined with the first moment of g_1^d previously measured on the same data, this result favours a non-symmetric polarisation of light quarks Delta u-bar = - Delta d-bar at a confidence level of two standard deviations, in contrast to the often assumed symmetric scenario Delta u-bar = Delta d-bar = Delta s-bar = Delta s.Comment: 7 pages, 3 figures, COMPASS, revised: details added, author list update

Collins and Sivers asymmetries in muonproduction of pions and kaons off transversely polarised protons

Measurements of the Collins and Sivers asymmetries for charged pions and charged and neutral kaons produced in semi-inclusive deep-inelastic scattering of high energy muons off transversely polarised protons are presented. The results were obtained using all the available COMPASS proton data, which were taken in the years 2007 and 2010. The Collins asymmetries exhibit in the valence region a non-zero signal for pions and there are hints of non-zero signal also for kaons. The Sivers asymmetries are found to be positive for positive pions and kaons and compatible with zero otherwise. © 2015

Mobile visualization of data on wireless network electromagnetic radiation

The relevance of the discussed issue is caused by the need to analyze the influence of wireless networks to human health. This problem is oriented to such science directions as geoecology and geoinformatics. The density of electromagnetic pollution is analyzed through determining the number of radiation sources and their radius of action. The main aim of the study is to search and analyze the information on electromagnetic radiation emanating from surrounding wireless networks: cellular, Wi-Fi and Bluetooth, using specially developed software for mobile devices. The methods used in the study: methods and tools for software design and development, geographic information systems, mathematical methods of triangulation, multivariate optimization and filtering of signals, the inverse square law, practical measurement experiments. The results. The authors have stated and solved the problem of searching and analyzing the information on electromagnetic radiation emanating from the surrounding wireless networks: cellular, Wi-Fi and Bluetooth. The paper describes the methods and tools, technologies, programming and mathematical foundations of the developed mobile Android-application and considers the issues of receiving, triangulation and filtering radiation signals. The developed Android-platform mobile software is described in details; the paper is illustrated by screenshots. The results of experimental measurements and calculations of the radiation source power, and the range of the wireless network (cellular, Wi- Fi and Bluetooth) are analyzed

Mobile visualization of data on wireless network electromagnetic radiation

The relevance of the discussed issue is caused by the need to analyze the influence of wireless networks to human health. This problem is oriented to such science directions as geoecology and geoinformatics. The density of electromagnetic pollution is analyzed through determining the number of radiation sources and their radius of action. The main aim of the study is to search and analyze the information on electromagnetic radiation emanating from surrounding wireless networks: cellular, Wi-Fi and Bluetooth, using specially developed software for mobile devices. The methods used in the study: methods and tools for software design and development, geographic information systems, mathematical methods of triangulation, multivariate optimization and filtering of signals, the inverse square law, practical measurement experiments. The results. The authors have stated and solved the problem of searching and analyzing the information on electromagnetic radiation emanating from the surrounding wireless networks: cellular, Wi-Fi and Bluetooth. The paper describes the methods and tools, technologies, programming and mathematical foundations of the developed mobile Android-application and considers the issues of receiving, triangulation and filtering radiation signals. The developed Android-platform mobile software is described in details; the paper is illustrated by screenshots. The results of experimental measurements and calculations of the radiation source power, and the range of the wireless network (cellular, Wi- Fi and Bluetooth) are analyzed

Diffractive and Parton Processes with Forward Detectors at the LHC

The Compact Muon Solenoid (CMS) experiment, in the Large Hadron Collider (LHC) at CERN, has several forward sub-detectors, consisting of calorimeters close to the beam pipe, that complement the central part of CMS, which covers a pseudorapidity range from -3 to +3. The TOTEM experiment, installed around the same interaction point as CMS, is tailored for diffractive measurements. CMS and TOTEM have strengthened their collaboration on a common project to achieve maximum forward acceptance and to perform measurements at full LHC luminosity.The Compact Muon Solenoid (CMS) experiment, in the Large Hadron Collider (LHC) at CERN, has several forward subdetectors, consisting of calorimeters close to the beam pipe, that complement the central part of CMS, which covers a pseudorapidity range |η|<3 . The TOTEM experiment, installed around the same interaction point as CMS, is tailored for diffractive measurements. CMS and TOTEM have strengthened their collaboration on a common project to achieve maximum forward acceptance and to perform measurements at full LHC luminosity

RESEARCH AND INNOVATION ACTIVITY OF THE STAVROPOL STATE AGRARIAN UNIVERSITY: TENDENCIES AND RESULTS

The article describes approaches to stimulate the development of innovations and science at the Stavropol State Agrarian University on the example of R&D Department. This center promotes scientific-research and innovative activities of the teaching staff, postgraduates and students, provides the coordination and organization of the innovative activities at the University, cooperation of the University with ministries and departments, agricultural enterprises and business structures of the Northern Caucasus Federal District. Particular attention is paid to the interaction system between scientists and consumers. This system includes special algorithms of grant and project financing, intellectual property protection, publication of the results of scientific andtechnical activities. Statistic information about the University scientists’ participation in the innovation process is given