New Opportunities for the Humanities: Professional Polylogue in a Multilingual World Review of the first international scientific and practical conference “Professional polylogue in a multilingual world: language, culture, method” (Moscow, April 6–7, 2023)

This paper presents a review of the first International Scientific and Practical Conference “Professional Polylogue in a Multilingual World: Language, Culture, Method”, which was held at MGIMO University (Moscow, Russia) on April 6–7, 2023. The conference aimed to explore various issues related to linguistics, foreign language teaching, and socio-cultural factors in modern language education. The event brought together over 300 specialists who participated as speakers and active listeners in seven sections, three online discussion panels, a round table, and a student section “Potential”. Discussions included significant aspects of foreign language learning, trends and stages in foreign language teaching methods, the formation of professional identity in a multilingual world, and the cultural aspect of learning and self-development of both students and teachers

EPIDEMIOLOGICAL SITUATION ON CHOLERA ACROSS THE GLOBE AND IN THE RUSSIAN FEDERATION IN 2007–2016. FORECAST FOR 2017

Analysis of epidemiological situation on cholera around the world has demonstrated downward trend in morbidity rates in 2016; annual average decline being 3.907 % (by reference to 2007). Comparative assessment of monthly incidence in 2015 and 2016 shows perennial registration of cholera cases in a number of African countries and in the Caribbean with up-rises in different seasons. Establishment of epidemic foci is on-going. Between 2007 and 2016, 1733 imported cases of cholera took place across the globe. Interstate import dominated in Asia. For forecast development, for the first time ever, risk assessment of epidemic process activation has been performed, taking into consideration emergency situations of varying origin, social and natural environments, using expert evaluation scores. Epidemic manifestations of cholera in the Russian Federation were characterized by import of the infection in 2008, 2010, 2012, and 2014; isolation of V. cholerae O1 biovar El Tor ctxA– tcpA–, ctxA+ and V. cholerae O139 ctxA– and tcpA– from surface water bodies, as well as individual V. cholerae O1 biovar El Tor сtхA+ tсра+. Worked out has been the algorithm for epidemiological investigation of causes and conditions of surface water body contamination with cholera vibrios. Cholera forecast worldwide and in Russia for the year 2017 remains unfavorable

EPIDEMIOLOGICAL SITUATION ON CHOLERA ACROSS THE GLOBE AND IN THE RUSSIAN FEDERATION IN 2007–2016. FORECAST FOR 2017

Analysis of epidemiological situation on cholera around the world has demonstrated downward trend in morbidity rates in 2016; annual average decline being 3.907 % (by reference to 2007). Comparative assessment of monthly incidence in 2015 and 2016 shows perennial registration of cholera cases in a number of African countries and in the Caribbean with up-rises in different seasons. Establishment of epidemic foci is on-going. Between 2007 and 2016, 1733 imported cases of cholera took place across the globe. Interstate import dominated in Asia. For forecast development, for the first time ever, risk assessment of epidemic process activation has been performed, taking into consideration emergency situations of varying origin, social and natural environments, using expert evaluation scores. Epidemic manifestations of cholera in the Russian Federation were characterized by import of the infection in 2008, 2010, 2012, and 2014; isolation of V. cholerae O1 biovar El Tor ctxA– tcpA–, ctxA+ and V. cholerae O139 ctxA– and tcpA– from surface water bodies, as well as individual V. cholerae O1 biovar El Tor сtхA+ tсра+. Worked out has been the algorithm for epidemiological investigation of causes and conditions of surface water body contamination with cholera vibrios. Cholera forecast worldwide and in Russia for the year 2017 remains unfavorable

Impact of Cultivating Environment on the Terms of Persistence and Certain Properties of Cholera Vibrios

Objective of the study is to investigate the impact of cultivating temperature and medium on the terms of persistence, ctx gene retention, and enzymatic activity of V. cholerae O1 with various toxigenicity.Materials and methods. Utilized were the strains of V. cholerae El Tor: P-5879, P-19613, and also the strain P-19787.Results and conclusions. In the process of studying cholera vibrios El Tor with different genetic characteristics it was determined that the longest terms of persistence (19 days) on mineral substrates at 5 ºC were observed for toxigenic strains, while for non-toxigenic ones it made less than 17 days. At the same time cholera vibrios can persist continuously and even reproduce on mineral substrates under the conditions of subnormal lowered temperatures (not less than 10 °C). Toxigenic strains of Vibrio cholerae, irrespectively of cultivating medium and temperature, retained ctx gene in their genome and maintained enzymatic activity throughout the experiment. Such long-term persistence of cholera vibrios at low temperatures on mineral substrates may be regarded as possibility of preservation of V. cholerae toxigenic strains in case of import by the infected persons or vibrio-carriers

Convention on Air Law: What It Is Like to Be

It’s for many years that the revision of the Chicago Convention on Civil Aviation of 1944 is discussed. Still more acute is the need for the Convention on Air Law (CAL) from the point of view of united legal regime for any flights and any kinds of activity in airspace which constitute the interdependent system. The experience of European Union in this respect is mostly successful. Less successful are the CIS member-States, which just formally declared United Airspace (UAS). Still in both cases we have just Functional Airspace (FAS) declared for certain flights and activities.The States-members of Pact of Ands created FAS for commercial aims.FAS is declared by all regional organizations in the sphere of air navigation: ASECNA, EUROCONTROL, COCESNA etc. It is possible to use the term “United Airspace of the Convention on Air Law” keeping in mind (among all) the idea of creation of Global Navigation Satellite System (GNSS) based on GPS, GLONASS and GALILEO.CAL will help to settle a number of “frozen” (traditional) problems (disputes) of air law, as well as new ones, with the help of a new Global Organization on the Use of Air Space (GOUAS). It will also promote the creation of stable legal base for the functional “flight cyber space”.As to the procedural aspects of the problem it advisable to use the experience of Convention on the Law of the Seas of 1982 and of Draft Convention on the Law of Outer Space proposed by Russia in 2000.In any case it should be kept in mind that many States oppose the idea of global agreement on exchange of commercial rights in air transport.So the CAL should be mostly devoted to the public aspects of International Air Law

From Foreign Languages to a Profession: The Professional Identity Formation During the Lessons of a Foreign Language for Special Purposes (Lexical and Professional Aspects)

Thesis. The authors of the study consider important issues of the professional competencies formation during the process of teaching a foreign language to law students as a process of their professional identity formation. The authors had to identify by interviewing students what types of exercises help them to master their chosen speciality in a foreign language. Methods. The authors rely on comparative, competitive methods, as the interdisciplinary approach principles. Comparing the programmes of teaching a foreign language of speciality and international law, the authors build a system of a single learning process as one of forming a professional identity. Results. Authors of the study tried to build the process methodology of teaching the language of the speciality as a formative one of students’ professional identity. The authors cited as an example the system of methods and exercises used in the language lessons of the speciality, with the aim of formation of not only linguistic but also legal professional competencies. Conclusion. The process of forming a professional identity in the process of studying at a university is one of the most important in the development of the professional personality of a future specialist. Teaching a foreign language in humanitarian universities is an important process which should be revised in accordance with the main discipline teaching programmes. It’s important to create such methodological complexes that would allow the speciality language lessons to bring the learning process as close as possible to a professional one

Strengthening the development of Russian regions based on human management, intellectual and innovative potential

A key source of economic growth at present is the development of regions of Russia. In this regard, in the regions, there is a need to strengthen and develop human, intellectual and innovative potential. The material factors of production, labour, patents, licenses, know-how, model programs, finding growing application in all spheres of society and its subjects are the basic forms of materialization of intellectual potential. The problem of strengthening the development of regions based on the management of human, innovative and intellectual potential is currently not sufficiently considered by economists. The need for management of human, innovative and intellectual potential at the present stage is due to three main factors: the state of the economy of regions of Russia, the shortcomings of the market mechanism of self-regulation, innovation, and General economic goals of socio-economic development of regions of Russia. The presence in the Russian regions significant potential in combination with high-tech industries can be a Foundation for implementing large-scale growth of innovative activity of the country. Innovations affect the development of the productive forces, they contribute to increased welfare in the region, improving the quality of life, level of education, thereby increasing the innovative potential of the region. Innovative opportunities in our view, are an important component of the integration potential. They represent opportunities and strategies, the implementation of which allows to ensure the planned and progressive development through a purposeful transformation of the innovations in innovation. In turn, innovative capabilities depend on the available regional resources. In our opinion, the development of theoretical provisions and recommendations for the management and use of human, intellectual and innovative potential of the region can help the user to correctly Orient in the current situation and to develop a set of measures for stable and steady development of regions of Russia

THE EFFICACY OF HIGH-DOSE CONSOLIDATION AND AUTOLOGOUS BONE MARROW TRANSPLANTATION IN FIRST REMISSION OF ACUTE MYELOID LEUKEMIA

Introduction. The question of the most adequate treatment strategy of AML in cases when it is impossible to perform allogeneic HSCT because of any reason still remains open.The aim of this study was to assess the long-term survival of patients with AML who received chemotherapy (CT) or autologous HSCT as consolidation in the first remission of the disease. It was included 135 patients aged 18 to 67 years, with a verified diagnosis of AML (except FAB M3) in the study. Of these, 100 patients received only CT, 35 patients received consolidation with autologous bone marrow transplantation. Patients who achieved remission after completion of induction CT courses received one of three treatment options as consolidation: 1) chemotherapy of standard-intensity (sCT), 2) high-dose chemotherapy (HDCT), 3) autologous HSCT (autoHSCT) conducted after 1–2 courses of high-dose CT. Adverse prognostic factors were identified as: age over 40 years, hyperleucocytosis more than 50,0 × 10 9/L and unfavorable cytogenetic and molecular-biological risk group.Materials and methods. Depending on the number of prognostic factors at the onset of disease relapse-free survival (RFS) was 47 % in their absence, 45 % in the presence of 1 factor, in the presence of 2 factors – 14 % (p = 0,000), regardless of the variant of consolidation therapy (sCT, HDCT, autoHSCT). A high level of white blood cells adversely affects OS (38 % vs. 22 %) and increases the frequency of relapse (52 % vs. 69 %) when performing only CT (sCT and HDCT). At initial white blood cells level more than 50,0 × 10 9/L the 5-year OS was 60 % when performing both autoHSCT and HDCT. Performance of autoHSCT at failure to achieve remission after the 1st induction course CT is associated with the best 2-year OS (62 % vs. 35 %, p = 0,05), EFS (50 % vs. 22 %, p = 0,05) and RFS (50 % vs. 37 %, p = 0,05) in comparison with HDCT and sCT. In favorable cytogenetic risk group 5-year RFS was 80 % when performing autoHSCT and 67 % when performing HDCT; the 5-year OS was 80 % regardless of consolidation therapy option.Conclusion. AutoHSCT is the preferred consolidation option in favorable risk group patients, and after failure to achieve remission after the 1st CT course

PROGNOSTIC SIGNIFICANCE OF POSITRON EMISSION TOMOGRAPHY IN AUTOLOGOUS STEM CELL TRANSPLANTATION FOR NON-HODGKIN’S LYMPHOMA

Objective: evaluation and comparison of positron emission tomography (PET) prognostic value with other predictors of effectiveness in patients with non-Hodgkin’s lymphoma (NHL) receiving high-dose chemotherapy with autologous hematopoietic stem cell transplantation (AHSCT).Materials and methods. The retrospective data on 49 consecutive patients with NHL  receiving high-dose chemotherapy with АHSCT was               analyzed. The median age was 36.2 (7–60)  years. Median follow-up is currently 24 (1–82)  months. Prognostic factors analyzed included sex, response to the initial chemotherapy, time to relapse, second-line chemotherapy regimen type, B-symptoms on relapse, serum lactate dehydrogenase and albumin levels, response assessed by computer tomography (CT), number of chemotherapy lines, condition regimen, PET-scan results before (PET1, n = 49) and after (PET2, n = 39) AHSCT.Results. Two-year overall and event-free survivals were 74.4 and 79.1 %, respectively. Patients with CT-confirmed progression prior to AH-SCT had the worse prognosis. Prognostic significance of PET-status  was shown in chemosensitive patients (partial/complete response).The overall survival in PET1-negative and PET1-positive patients were 95.4 vs 71.0 % (р = 0.019), respectively. In PET2-positive and PET2-negative patients the overall and event-free survivals were 59.8 vs 100 % (р = 0.001) and 54.4 vs 94.4 % (р = 0.02), respectively.     In combined analysis of PET1 and PET2 statuses prognostic significance of PET2 prevailed over PET1 results significance. The multivariate analysis confirmed only PET1 significance for survival prediction.   Conclusion. Chemosensitivity of the tumor, assessed by CT, is the most important prognostic factor. In chemosensitive patients achievement PET1 or PET2 negativity means better prognosis. The patients with PET positivity prior and after AHSCT have the worst prognosis