<i>N</i>-Aminosulfamide Peptide Mimic Synthesis by Alkylation of Aza-sulfurylglycinyl Peptides

<i>N</i>-Aminosulfamides are peptidomimetics in which the C_αH and the carbonyl of an amino acid residue are both respectively replaced by a nitrogen atom and a sulfonyl group. Aza-sulfurylglycinyl tripeptide analogs were effectively synthesized from amino acid building blocks by condensations of <i>N</i>-protected amino hydrazides and <i>p</i>-nitrophenylsulfamidate esters. The installation of <i>N</i>-alkyl chains and access to other aza-sulfuryl amino acid residues were effectively achieved by chemoselective alkylation

<i>N</i>-Aminosulfamide Peptide Mimic Synthesis by Alkylation of Aza-sulfurylglycinyl Peptides

<i>N</i>-Aminosulfamides are peptidomimetics in which the C_αH and the carbonyl of an amino acid residue are both respectively replaced by a nitrogen atom and a sulfonyl group. Aza-sulfurylglycinyl tripeptide analogs were effectively synthesized from amino acid building blocks by condensations of <i>N</i>-protected amino hydrazides and <i>p</i>-nitrophenylsulfamidate esters. The installation of <i>N</i>-alkyl chains and access to other aza-sulfuryl amino acid residues were effectively achieved by chemoselective alkylation